| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Regulation of Aging |
| Session Chair: Mona Nemer |
| Leonard P. Guarente, Massachusetts Institute of Technology
SIR2 and hormone action |
| Cynthia Kenyon, University of California, San Francisco
Insulin/IGF-1 Signaling and Longevity |
| 9:30 pm | WELCOME RECEPTION |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Group Photo |
| 9:00 am - 12:30 pm | GPCR Signaling |
| Session Chair: Jacques E. Dumont |
| Marc G. Caron, Duke University
GPCR regulatory mechanisms |
| Thomas M. Wilkie, Southwestern University
RGS/G protein regulation in mammalian development and physiology |
| Emiliana Borrelli, Institut De Génétique Et Biologie Moléculaire Et Cellulaire
Specificity of dopamine receptor signaling |
| Philip Wedegaertner, Thomas Jefferson University
Membrane Targeting of G Proteins |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Regulation Of Gene Expression By Nuclear Receptors |
| Session Chair: Nancy Weigel |
| Christopher K. Glass
Negative regulation of gene expression by nuclear hormone receptors |
| Michael R. Stallcup, University of Southern California
Roles of protein methylation and protein-protein interactions in coactivator function |
| Marion Desclozeaux, University of California San Francisco
Regulation of constitutively active orphan nuclear receptors via posttranslational modifications
|
| Short Talk: Alexander Mazo, Kimmel Cancer Center
Histone H3-lysine 4 methylation in ecdysone-dependent development of Drosophila |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Signaling in Organogenesis |
| Session Chair: Kathleen A. Mahon |
| T. Rajendra Kumar, Baylor College of Medicine
Gonadotropin signaling and testis development |
| James C. Cross, University of Calgary
Signaling interactions underlying placental morphogenesis |
| Sally A. Camper, University of Michigan
Wnt and notch signaling in pituitary development |
| Jeffrey M.Rosen, Baylor College of Medicine
Stem cells in normal mammary gland development and breast cancer |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Metabolic Regulation |
| Session Chair: Peter Tontonoz |
| Sheila Collins, Duke University School of Medicine
Signaling networks controlling lipid mobilization and thermogenesis |
| Amira Klip, The Hospital for Sick Children
Regulation of glucose transporters by insulin: signal transduction meets intracellular traffic |
| Bruce Spiegelman, Dana-Farber Cancer Institute
Transcriptional basis of glucose and energy homeostasis
|
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell Specificity Of Steroid Signaling |
| Session Chair: Catherine Thompson |
| Stavros C. Manolagas, University of Arkansas for Medical Sciences
Dissociation of skeletal from reproductive effects of sex steroids by activation of nongenotropic signals |
| Sophia Y. Tsai, Baylor College of Medicine
Orphan nuclear receptor, COUP-TFII and organogenesis |
| Cathy L. Mendelsohn, Columbia University
Vitamin A-dependent epithelial/mesenchymal signaling pathways critical for urogenital tract formation |
| David L. Lohnes, Institut de Recherches Cliniques de Montréal
Convergence of retinoid and Wnt signaling pathways in development |
| Short talk: Onno Bakker, University of Amsterdam
Zonal expression of thyroid hormone receptors in heart |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Integration Of Phosphorylation Cascades |
| Session Chair: Jacques Drouin |
| Stanley McKnight, University of Washington
Protein kinase A mutant mice |
| Liliana Attisano, University of Toronto
TGF superfamily signaling |
| Anne Brunet, Boston Children's Hospital
PI3K signaling |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Identification of New Targets |
| Session Chair: Ming-Jer Tsai |
| Philippe Walker, AstraZeneca
Target class approach to GPCR drug discovery |
| Simon Rousseau, University of Dundee
Identification of novel physiological substrates for the SAPK2/p38 signalling pathway |
| Vincent Giguère, McGill University
Functional genomics and genetic analyses of nuclear receptor signaling networks |
| Diane M. Robins, University of Michigan Medical School
Mechanisms of sex-specific gene expression
|
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Integration of cell signaling |
| Session Chair: Bruce Spiegelman |
| David D. Moore, Baylor College of Medicine
CAR: not just a xenobiotic receptor |
| Paolo Sassone-Corsi, Institute De Génétique Et Biologie Moléculaire Et Cellulaire
Coupling Signaling to Gene Expression: A physiological scenario |
| 9:30 pm | Closing reception |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
