Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Structure and Mechanisms of ABC Transporters
7:40 pm - 8:05 pm
"ABC Transporters Implicated in Biopolymer Translocation"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Cryo-EM Studies of an ATP-Binding Cassette Lipid Transporter"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Structural Basis for Antibacterial Peptide Self-Immunity by Bacterial ABC Transporters"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Cryo-EM Snapshots of Substrate Recognition by the Multidrug Resistance Transporter MRP1"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Forefront of Structural Biology of Transport
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Structure and Mechanism of Neurotransmitter Sodium Symporters"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Antigens on the Move – New Twists and Turns in Adaptive Immunity"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Structural Insights into Bacterial Lipoprotein Biosynthesis"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"New Insight into the Structure of TRPV Channels"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Structure of a Eukaryotic Voltage-Gated Sodium Channel at Near Atomic Resolution"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"The Complete Structure of an Activated Open Voltage Gated Sodium Channel Reveals a Novel Gating Interaction Motif"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Living in the Lipid Bilayer
7:30 pm - 7:55 pm
"Impact of Specific Lipids on Membrane Transport, Two Sides of the Same Coin?"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Measuring the Free Energy of ClC-ec1 Dimerization in Membranes Using Single-Molecule Photobleaching Analysis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Probing Membrane Protein-Lipid Interactions by Native Ion Mobility Mass Spectrometry"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Heads or Tails: Lipid Inhibitors of the Glycine Transporter, GlyT2"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structure, Dynamics and Mechanisms of Secondary Transporters
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Multimodal Approach to Understanding clc-7 Function in Lysosomes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Structural and Dynamic Studies of Excitatory Amino Acid Transporters"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
"Lipids and Proton Transport in Na+/H+ Antiporters"
10:40 am - 10:50 am
Discussion
10:50 am - 11:20 am
Group Photo / Coffee Break
11:20 am - 11:45 am
"Structural Insight into the Role of the Ton Complex in Transport Across the Outer Membrane"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Deciphering Ligand Induced Conformational Changes in the Sodium Galactose Transporter (SGLT)"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Ion Interactions with Membrane Proteins
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"EmrE Sacrifices Coupling Efficiency to Achieve Multidrug Promiscuity"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Probing the Structure and Ion-Coupled Mechanism of the Multidrug Transporter EmrE Using NMR Spectroscopy"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Exploring Protein Sequence Information Across Nature's Hot and Cold Habitats to Understand the Functional Dynamics in the Glutamate Transporter Family"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Oligomer Interfaces of the Human Dopamine Transporter"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Energy Landscapes of Membrane Transport Proteins
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Multidimensional Free Energy Landscape Governing Structural Transitions of a Neurotransmitter Transporter in Membrane"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"The Dos and Don'ts of Active Transporters: An Energy Landscape Perspective"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Imaging Functional Dynamics Within Individual Transporter Proteins Using Single-Molecule FRET"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Single Molecule Studies Reveal Ligand Binding Dynamics in Pacemaker Ion Channels"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Driving Forces for Folding Membrane Proteins"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Ligand-Gated Channels: Recent Updates
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Allosteric Mechanisms Underlying Pentameric Ligand-Gated Ion Channel Modulation"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Structure and Energy Landscapes of Ionotropic Glutamate Receptor"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Competition Between S-Components for a Common Energizing Module"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Ion Channels: Structure and Function
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Insights into the Mechanisms of KATP Channel Assembly and Gating from Cryo-EM Structures"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Structures of K2P and TRPP Channels by X-Ray, xFEL and Cryo-EM"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
" Studies of the Epithelial Calcium Channel TRPV6"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Exploring the Complex Dynamics of an Ion Channel Voltage Sensor Domain via Computation"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Helical Jackknives Control the Double-Pore K+ Uptake System KtrAB"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Omega-3 Polyunsaturated Fatty Acids Enhance Human Endothelial Cells Response by Recruiting Transient Receptor Potential Channels"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Personalized Medicine: Disease-Causing Mutations in Channels and Transporters
7:30 pm - 7:55 pm
"Failure to Prime the Dopamine 'Pump' in Autism"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Mutations in the Neutral Amino Acid Transporter LAT1 Are a Cause of Microcephaly and Autism"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Murphy's Law of the Sodium Pump"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure