Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Interplay Between Proteins and Membranes
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:20 pm
"Structural Basis of Calcium-Dependent Phospholipid Scrambling by TMEM16 Proteins"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"How Direct Protein-Lipid Interactions Shape the Conformational Landscape of Secondary Transporters"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"The Flips and Flops of a Scramblase story: Insights into the Activation and Transport Mechanism of TMEM16 Proteins"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Linking Transport and Metabolism
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Mechanics of Transition Metal Ion Transport by an Nramp Transporter"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Structure of the Human LAT1-4F2hc Heteromeric Amino Acid Transporter Complex"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 10:55 am
"Structural Basis for pH-Dependent Retrieval of ER Proteins from the Golgi by the KDEL Receptor"
10:55 am - 11:00 am
Discussion
11:00 am - 11:25 am
"Outer Membrane Nutrient Processosomes in Dominant Human Gut Bacteria"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Translocation Mechanisms of Protein-Antibiotics"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Of Channels and Transporters: Potassium Uptake in Bacterial Survival"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
ABC Transporters in Health and Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Insight into Drug Transport and Small-Molecule Inhibition of Human ABCB1 and ABCG2"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Architectures of Lipid Transport Systems for the Bacterial Outer Membrane"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Conformational Space of a Heterodimeric ABC Exporter Under Turnover Conditions"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Mechanism of Allosteric Regulation of P-Glycoprotein"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Ion Channels: From Atom to Animal
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Structural Titration of Human IP3 Receptors Reveals Mechanisms of Ligand-Dependent Gating"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Lipid Modulation of CNG Channels"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Group Photo / Coffee Break
10:40 am - 10:55 am
"A Molecular Basis for Membrane Mediated Inhaled Anesthesia"
10:55 am - 11:00 am
Discussion
11:00 am - 11:25 am
"Architecture of the Proteolysis-Regulated Epithelial Sodium Channel"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Structural Basis of Dynamic TRP Channel Interaction with Lipids, Proteins and Cations"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Structure and Mechanism of P4-ATPase Lipid Flippases"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Folding in the Membrane
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Co-Translational Folding of Major Facilitator Superfamily Transporters"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Functional Mechanisms in Channels and Transporters"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Defining Membrane Boundaries of Proteins Using Electron Density Maps: The MemBlob Database and Server"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"How ATP Control of Pre-Protein Folding and the PMF Help Drive Protein Transport Across Membranes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Computational Design and Evolution of Function
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Simulating Alternating Access of Sodium Symporters"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Structural and Mechanistic Diversity of Vitamin B12 Transporters"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Structure of an Intermediate in the CLC Transport Cycle"
11:05 am - 11:15 am
Discussion
11:15 am - 11:30 am
"Personalized Structural Biology of the Voltage-Gated KCNQ1/KCNE1 Potassium Channel"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Evolution of Drug Export in the Small Multidrug Resistance Family"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Focusing the Computational Microscope on the Cell Envelopes of Gram-Negative Bacteria"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
New Technologies for Uncovering Mechanistic Insight
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Function and Pharmacology of Voltage-Gated Ion Channels"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Exploring a Multidrug Efflux Transporter by Deep Mutational Scanning"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"The Salipro System for Stabilization of Membrane Proteins"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Probing SERT Function with a Serotonin Biosensor"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membrane Transporters and Channels Impacting Health and Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"An Allosteric Oxyanion Binding Site Controls Na+/I- Symporter (NIS) Transport Stoichiometry"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Molecular Mechanisms of P2X3 Receptor Channel Activation and Modulation by Divalent Cation Bound ATP"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"The Split Personality of Glutamate Transporters: A Chloride Channel and a Transporter"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"How Toxins Modify Sodium Channels"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
"Nicotinic Receptor Reconstitution and Structure"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Import Mechanism of the Human Serotonin Transporter Revealed Through Mutational and Computational Energy Landscapes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Concepts in Membrane Transport Biology
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"Understanding Protein-Lipid Interactions in a Ciliary Membrane TRP Channel"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:20 pm
"Cryo-EM Structures of MscS in a Lipid Bilayer and the Molecular Basis of 'Force from Lipids' Gating in Mechanosensitive Channels"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Role of Lipids in Dimer Formation of a Purine Transporter"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"How One Strong H-Bond Screws up a Transporter"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure