Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Paradigm-Shifting Discoveries in Membrane Transport
7:40 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:25 pm
"How Proteins Cross Membranes"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"A Comparative Perspective on Proposed Mechanisms of Proton Translocation in Complex I and its Relatives"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Diverse Gating Mechanisms of Ion Channels
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"A Synthetic Potassium Channel Reduces Oxidative Stress via Cellular Adaptronics"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Mechanically-Induced Gating in OSCA/TMEM63 Channels"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Gating and Regulation of SWELL1 Volume-Regulated Anion Channel"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Secondary Active Transporters in Health and Disease
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Determinants of Substrate Selectivity in Nramp-Family Transition Metal Transporters"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"A (Male) Na+ /H+ Exchanger with Potential"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"The Molecular Mechanisms Underlying Cellular Uptake of Vitamin A"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanism of Primary Active Transport
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Mechanism and Energetics of AE1 Elevator Transport Cycle in Red Blood Cells"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Short Talk Selected from Poster Abstracts
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Conserved and Unique: Mapping Protein Dynamics to Rethink Drug Discovery"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"An Evolutionary, Structural and Mechanistic Link Between Primary and Secondary Transporters"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Late-Breaking Topic
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Interplay Between Lipids and Membrane Proteins
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Dietary Fatty Acids Modulate the Function of PIEZO Mechanosensitive Ion Channels"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"LYCHOS is a Human Hybrid of a Plant-Like PIN Transporter and a GPCR"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Molecular Basis of Neurosteroid and Anticonvulsant Regulation of TRPM3"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Diversity in Membrane Transport
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Membrane Protein Quality Control at the ER"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Protein Translocation in Unconventional Release of Leaderless Secretory Proteins"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Structural Mechanisms of Olfaction in Insects"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Mechanisms of Plant Hormone Transport"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Structural and Functional Diversity of Channelrhodopsins"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Conformational Dynamics of ABC Transporters In Vitro and In Silico"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Drugs on Membrane Transport Targets
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Modulation of Pentameric Ligand-Gated Channel Function"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Computer Driven Structure Based Ligand Discovery Targeting Membrane Proteins: Advances and Challenges"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Insight into Drug, Lipid, and Bile Salt Transport from Structural and In Vitro Transport Studies"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Physiological Connections to Transport Mechanisms
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Solute Carriers in Brain Metabolism"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
Late-Breaking Topic
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"An Unanticipated Species Difference in Function"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"CFTR Function, Pathology and Pharmacology at Single-Molecule Resolution"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Transport Mechanisms in the Golgi Membrane"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Allosteric Modulation of Neurotransmitter Transporters: A Structural and Functional Perspective"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Conformational Dynamics in Membrane Transporters and Channels
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"NMDA Receptors: Dynamic Control of Ca2+ Permeability"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Ligand Dependent Conformational Changes of Membrane Proteins"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Physical Coupling of Transport and Signaling in Antimicrobial Resistance Mechanisms"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Late-Breaking Topic
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure