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Medicinal Chemistry

Gordon Research Conference

Communicating Innovations in Small Molecule Drug Discovery

August 3 - 8, 2025

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GRC Education Requirements: Undergraduates or those who have not obtained a bachelor's degree in science/engineering (or acceptable equivalent) are not eligible to apply to attend Gordon Research Conferences or Seminars.

Chair

Vice Chair

Colby-Sawyer College

541 Main Street

New London, New Hampshire, United States

Venue and Travel Information

Application Information

Applications for this meeting must be submitted by July 6, 2025. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the conference chair if more seats become available due to cancellations.

Conference Description

The Medicinal Chemistry GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The 2025 Medicinal Chemistry Gordon Research Conference will feature talks on the cutting edge of the discipline that include new technologies, therapeutic modalities, and molecules advancing drug discovery. Emily Peterson of Novartis is responsible for the scientific program; please see the planned topics and contact the Chairs if you would like to submit a talk proposal. A preliminary program of speakers will be posted in November 2024.

In addition to the various scientific sessions, the conference will culminate with a “Late-Breaking Topics” session organized by David Weinstein of Vividion Therapeutics. This session comprises late-breaking results on prioritized clinical candidates across therapeutic areas. Finally, the conference program will conclude on Thursday evening with the Keynote address organized by the Chair.

We strongly encourage attendees to submit poster presentations on any aspect of Medicinal Chemistry as the poster sessions are an essential outlet for thoughtful discussion and interaction among the conferees. This year, the poster sessions will be organized by Julia Haas of Think Biosciences. Prospective applicants are expected to share unpublished or undisclosed data, along with any undisclosed chemical structures, within their poster presentations.

The 2025 Medicinal Chemistry GRC will continue a tradition of outstanding science presented in a relaxed atmosphere offering a variety of social activities. Vice Chair-Elect H. Rachel Lagiakos of Schrödinger will organize social events for the week, including hikes of Mt. Kearsarge and Mt. Cardigan, cycling, frisbee golf, cruising Lake Sunapee, volleyball, softball, soccer, a golf scramble, and a charity fundraiser.

As we look forward to another amazing conference in 2025, on behalf of myself, the Vice Chair, and the Vice Chair-Elect, we welcome your application. We particularly encourage applications from those of diverse backgrounds and scientific perspectives, and those who submit high-quality poster applications are given priority for admission considerations. We encourage applications by April 1, 2025, and the submission of any poster abstracts by April 15, 2025, to facilitate the admissions process.

Solicitations are not welcomed.

Thank you for your interest in the Medicinal Chemistry GRC!

Matthew Volgraf, Septerna

Chair, 2025 Medicinal Chemistry GRC

Related Meeting

This GRC will be held in conjunction with the "Medicinal Chemistry" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Organ Targeted Delivery Discussion Leader:
7:40 pm - 8:05 pm	"Inhaled Administration for Intra-Cellular Targets Exemplified by the Discovery of FRAP1 (mTOR kinase) Inhibitors"
8:05 pm - 8:20 pm	Discussion
8:20 pm - 8:45 pm	"Discovery of NVP-MIW491: Dermal Delivery of an LXR Agonist for the Treatment of Meibomian Gland Dysfunction"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:20 pm	"Development of a Colon-Targeted Pan-SIK Inhibitor for the Treatment of IBD"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	New Frontiers in Oncology Therapies Discussion Leaders: and
9:00 am - 9:30 am	"IL4i1 Inhibitors from Target Validation Through to First-In-Human Studies in Cancer Patients"
9:30 am - 9:45 am	Discussion
9:45 am - 10:15 am	"Identification of Dencatistat: An Isoform Selective CTPS1 Inhibitor for Multiple Oncology Indications"
10:15 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:30 am	"Structure- and Property-Based Design of Macrocyclic pan-KRAS Inhibitors"
11:30 am - 11:45 am	Discussion
11:45 am - 12:15 pm	"Discovery of MOMA-341, a Chemically Distinct, Potent and Selective Covalent Inhibitor of Werner Syndrome Helicase (WRN)"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Deconvolution Strategies for Phenotypic Screens Discussion Leader:
7:30 pm - 8:00 pm	"Discovery and Optimization of the First Specific Ribosome Biogenesis Inhibitor Targeting the AAA-ATPase NVL"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Phenotypic Screening and Target Deconvolution: Identification of a Chemical Series with Antiviral Activity Against Sarbecovirus with a Novel Mechanism of Action"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Identification of HbF-Activating CELMoDs™ Through Phenotypic Screening and the Subsequent Development of the ZBTB7A/WIZ Dual Degrader BMS-986470 for the Treatment of Sickle Cell Disease"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Innovations in Medicinal Chemistry to Advance Peptide Therapeutics Discussion Leader:
9:00 am - 9:30 am	"Oral Peptide Inhibitors of IL-1β for ASCVD"
9:30 am - 9:45 am	Discussion
9:45 am - 10:15 am	"Orally Bioavailable Macrocyclic Peptide Cyclin A/B RxL Inhibitors to Treat Cancers with High E2F Activity"
10:15 am - 10:30 am	Discussion
10:30 am - 11:00 am	Group Photo / Coffee Break
11:00 am - 11:30 am	"Discovery of FOG-001, a Clinical Stage Helicon Inhibitor of the Beta-Catenin/TCF4 Interaction"
11:30 am - 11:45 am	Discussion
11:45 am - 12:15 pm	"Advances in Peptide Conjugates: Exemplified by Macrocyclic Peptidic Degraders"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Overcoming Challenges in Achieving and Measuring Effective Therapeutic Concentration Discussion Leader:
7:30 pm - 8:00 pm	"Discovery of GS-4182, a Lenacapavir Prodrug to Treat HIV Infection with Once-Weekly Oral Administration"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Rapid Optimization of RUVBL1/2 Inhibitors Enabled by Single-Molecule Tracking"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Discovery of a Clinical Gut-Restricted KEAP1-NRF2 Inhibitor for the Treatment of Inflammatory Bowel Disease"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Advances in Neuroscience Discussion Leader:
9:00 am - 9:30 am	"Inhibition of Multiple System Atrophy with a New Class of Stacking Ligands for Fibrillar α-Synuclein"
9:30 am - 9:45 am	Discussion
9:45 am - 10:15 am	"Discovery of [¹¹C]MK-7337, A Novel High-Affinity Alpha-Synuclein PET Ligand for Imaging in Idiopathic Parkinson’s Disease Patients"
10:15 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:30 am	"Discovery of Novel Azaindazole GluN2B NAMs"
11:30 am - 11:45 am	Discussion
11:45 am - 12:15 pm	"Discovery of VENT-02: a Highly Brain-Penetrant NLRP3 Inhibitor for the Treatment of Neuroinflammatory Disorders"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Use of Artificial Intelligence and Machine Learning in Medicinal Chemistry, Challenges, Opportunities and the Limits Discussion Leader:
7:30 pm - 8:00 pm	"AI in Drug Discovery: Revolution, Evolution, or Complete Nonsense"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Are Co-Folding Methods Ready for Prime Time?"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Painting a Picture of AI at AstraZeneca: An HPK1 Case Study"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Late-Breaking Topics: First Disclosures of Clinical Candidates Discussion Leader:
9:00 am - 9:30 am	"Discovery of a First-in-class Molecular Glue Degrader, BMS-986463, for the Treatment of Advanced Malignant Solid Tumors"
9:30 am - 9:45 am	Discussion
9:45 am - 10:15 am	"Discovery of Clinical Candidate PF-07293893: A Novel and Selective AMPKγ3 Activator for the Treatment of Heart Failure"
10:15 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:30 am	"Discovery of GS-1427: A Potent, Selective, Oral Small Molecule Inhibitor of α4β7 for the Treatment of Inflammatory Bowel Disease"
11:30 am - 11:45 am	Discussion
11:45 am - 12:15 pm	Late-Breaking Topic
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Keynote Session: Humanizing Drug Discovery Discussion Leader:
7:30 pm - 8:30 pm	"Humanizing Drug Discovery"
8:30 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	General Discussion
9:15 pm - 9:30 pm	Closing Remarks
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Conference Links

Conference History Medicinal Chemistry (GRS) Contribute Financially to This Conference

Conference Fees

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Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

Preparing your GRC poster

Funding Opportunities

Financial assistance is available beginning in 2026 for qualified applicants through the Carl Storm Opportunity Fellowships program. Learn more.

Registration Fees

Conferee Single Room:

$990.00

Conferee Shared Room:

$940.00

Conferee Off-Site:

$785.00

Guest Single Room:

$800.00

Guest Shared Room:

$750.00

Guest Off-Site:

$595.00

Child 4-12 yrs Shared Room:

$375.00

Child 4-12 yrs Off-Site:

$298.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Bus Arriving:

$62.00

Bus Departing:

$62.00

Additional Fee Info

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