Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Evolutionary Innovation in Meiosis
7:40 pm - 7:55 pm
"Crossover Patterning Dynamics Under Chromosome Breaks and Fusions in Holocentric Rhynchospora Species"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
"Meiotic Segregation in the Holocentric Pantry Moth Plodia Interpunctella Occurs Through a Unique Center-Kinetic Mechanism Independent of Bivalent Structure"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"Meiotic Drive in Drosophila"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Gag-Derived Capsid Genes Prevent Age-Dependent Fertility Decline in Mammals"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chromosome Segregation and Aneuploidy
9:00 am - 9:15 am
"Sexually Dimorphic Meiotic Programs Create Specialized Gametes"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
"Cytoplasmic Kinetochore Filaments Regulate Vesicle Transport in C. Elegans Oocytes"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
"Deciphering Chromosome Segregation in Mammalian Eggs"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Decoding the Egg: Determining the Contribution of Kinesin Variants to Egg Aneuploidy"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Mammalian Spermatocytes Have the Capacity to Segregate Chromosomes Despite Centriole Duplication Failure"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"The Maintenance of Oocytes in the Mammalian Ovary Involves Extreme Protein Longevity"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
"Molecular Mechanisms Mediating Chromosome Stability in Human Eggs"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"The SMC-Condensin Subunit NCADP2 is a New Regulator of Prophase I Chromosome Assembly and Homologous Recombination in the Mouse"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:45 pm
"Evading Ageing: Mitochondrial and Proteostatic Adaptations in Oocytes"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Mechanisms That Maintain Spindle Integrity in Oocytes"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"Meiotic Spindle Assembly in Oocytes"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"HP1 Interacts with the Chromosomal Passenger Complex to Promote Spindle Assembly and Chromosome Segregation in Drosophila Oocytes"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Oocyte Meiotic Spindle Translocation Mediated by Organelle Exclusion"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Meiotic Chromosome Architecture: Pairing and Synapsis
9:00 am - 9:15 am
"Meiotic Silencing is Regulated by Gel-Like Phase Separation, but not by Chromatin Synapsis Status"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Pericentromeric Satellite DNA Repeats Stabilize Centromere Pairing Between Homologous Chromosomes During Meiosis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:00 am
"Targeted Disruption of SYCP1 N-Terminal Self Assembly During Mouse Meiosis"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"The Synaptonemal Complex Assembles Between Meiotic Chromosomes Through Adsorption"
10:20 am - 10:25 am
Discussion
10:25 am - 11:05 am
Group Photo / Coffee Break
11:05 am - 11:20 am
"The Synaptonemal Complex in C. Elegans "
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Holliday Junctions and the Synaptonemal Complex: Partners in the Maintenance of Meiotic Chromosome Synapsis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Homologous Interchromosomal Dynamics in Mouse Meiosis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Investigating Functional Specialization of Meiosis Specific Kleisins and HORMAD Proteins"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Meiotic Checkpoints and Cell Cycle Regulation
7:30 pm - 7:45 pm
"Understanding Meiosis II Regulation"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"New Perspectives on Meiotic Sex Chromosome Inactivation (MSCI) and the Sex Body of the Pachytene Spermatocyte"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"The Mechanisms Underlying the Transcriptional Activation of Meiotic Genes by the STRA8-MEIOSIN Complex"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"Orchestration of Spatial Signaling and Differentiation: Nutritionally Dependent ERK Signaling and Female Meiosis I Progression"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Initiation of Recombination: Induction and Regulation of DSBs
9:00 am - 9:15 am
"Uncovering Principles and Consequences of Mammalian Recombination Hotspot Evolution by Mapping PRDM9 Binding"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"MRE11 Suppresses Germline Mutagenesis at Recombination Hotspots in Mice"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"A Sexually Dimorphic Chromatin Landscape May Underlie Heterochiasmy in the Threespine Stickleback Fish"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Histone Methylation is Linked to Crossover Site Designation for Productive Late Prophase I Chromosome Remodeling During C. Elegans Meiosis"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
"In Vitro Reconstitution of Meiotic DNA Double-Strand-Beak Formation"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
"Structural and Biochemical Studies of Meiotic Recombination Initiation by SPO11"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Regulating the Sexually Dimorphic Recombination Landscape During C. Elegans Meiosis"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"A Molecular Mechanism for Meiotic DSB, Crossover, and Gene Conversion Interference"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:45 pm
"Enhanced Mutagenicity During Meiosis: The Involvement of DNA Repair and Recombination Genes"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Control and Fidelity of DNA Synthesis During Meiotic Recombination"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
"Making Dmc1 Run: Mechanism of Dmc1 Activation by Mei5-Sae3"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Anti-Crossover Functions of MMR and ZMM"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"The Regulation of Crossover Numbers and Distribution"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Control of Number and Distribution of Crossovers
9:00 am - 9:15 am
"Sex and Strain Differences in the Accumulation of Pro-Crossover Factors During Mouse Prophase I"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
"Defective Crossover Homeostasis Compromises Chromosome Segregation in Aged Mouse Spermatocytes"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
"A Maternal Age Effect on Meiosis in C. Elegans "
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Exo1 Protects DNA Nicks from Ligation to Promote Crossover Formation During Meiosis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Pairing, Patterning and Their Functional Interplay"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Protecting Recombination Intermediates to Ensure Chromosomal Crossing Over During Meiosis"
11:40 am - 11:45 am
Discussion
11:45 am - 12:00 pm
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Recombination and the Arabidopsis Centromeres"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetics and Gene Expression
7:30 pm - 7:45 pm
"Induction of Meiosis in Human Pluripotent Stem Cells by Expression of Regulatory Factors"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Preservation of Ovarian Reserve in Mice Through SKQ1 Treatment"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"Divergent Patterns of Meiotic Chromosome Remodeling"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"Protein Complex Assembly in Meiotic Cells"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"SETX is A Master Transcriptional Mediator During Meiotic Prophase"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure