Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Membrane Protein Misfolding in Neurological Diseases
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"Targeting Misfolding of PMP22 to Treat Charcot-Marie-Tooth Disease"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Molecular Determinants of Alpha-Synuclein Toxicity Revealed by Deep Mutagenesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"mRNA Interactions Promote Co-Translational Association of Heteromeric Membrane Proteins"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Cellular Response of Alpha-Synuclein Amyloids in Parkinson's Disease"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Role of the Lipids in Membrane Protein Folding
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Lipids Facilitate Protein Assembly at Membranes through Prewetting"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Discovery of Small Molecule Tools that Modulate Lipid Raft Stability and Protein-Raft Partitioning"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"The Role of Lipids in the Assembly of Bacterial Outer Membrane Proteins"
10:10 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Membrane Sensing Mechanisms at the Nuclear Envelope Domain of the ER"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Role of the Lipid Environment in Intramembrane Proteolysis by γ-Secretase and Related Proteases"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Measuring the Effects of a Membrane Protein on Peroxidized Lipids Membranes"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Eukaryotic Integral Membrane Protein Biogenesis
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Elucidation of Constraints on GPCR Biogenesis by Deep Receptor Scanning"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"Mechanisms at the Nexus of Membrane Protein Biogenesis and Degradation at the Endoplasmic Reticulum"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
"Dissecting SGTA Function Reveals Domain-Specific Roles and New Membrane Protein Clients"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
"Cotranslational Protein Folding on Human and Bacterial Ribosomes"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Giardia, do you GET that? Rewiring of a Conserved ER Targeting System"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
New Tools for the Study of Membrane Protein Folding
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"How the Mitochondrial Membrane Tunes the Conformations of Pro- and Anti-Apoptotic Proteins To Initiate or Inhibit Apoptosis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"CryoET Visualisation of Protein Biogenesis in Native Environment"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Single-molecule Tweezers for Studying Membrane Protein Folding and Interactions"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Next Generation Copolymers for the Characterization of Membrane Proteins in Near-Native Conditions"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Invitris’ Mammalian Cell-Free Expression Platform for Rapid Production of Difficult-to-Express Proteins"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Molecular Basis of Substrate Specificty Evolution in ABCG2"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Conformational States of Membrane Proteins
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Local Dynamics of Efflux Pumps Underlie Multidrug Recognition"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
"A Survey of Membrane Protein Structural Space"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Driving Oligomerization in Membranes by Burial of Membrane Defects"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
"Dynamics of 7-Transmembrane MembranePproteins from Solution NMR"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Bacterial Membrane Protein Biogenesis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Structural Basis of Lateral Gate Dynamics at the Bacterial Lipopolysaccharide Holo-Translocon"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Spatiotemporal Dynamics of the SecA/SecB-dependent Translocation Pathway in E. coli "
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"Single-Molecule Measurements of Membrane Protein Lipid Interactions and Topology Formation"
10:10 am - 10:15 am
Discussion
10:15 am - 10:30 am
"What Do Unfolded Outer Membrane Protein (uOMP) Ensembles Look Like?"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Membrane Mimetics for Folding Outer Membrane Proteins"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"A Fluorescent Reporter and Single-Turnover Kinetics Reveal New Insight into BAM Complex Function Supported by Live Cell Imaging"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Cotranslational Membrane Insertion of the Voltage-sensitive K+ Channel KvAP"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Dynamics and the Unfolding of Transmembrane Helices in GlpG Probed by HDX-MS"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Evolution and Design of Membrane Proteins
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"The Evolution of Complexity in a Family of Fluoride Exporters"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Building Functional Ion Channels From Scratch: Design Principles for Membrane Assembly and Selectivity"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"De Novo Design of Protein Nanopores With Defined Shapes and Functions"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"De Novo Design of Programmable Multi-domain Single-Pass Transmembrane Receptors for Rewiring Cellular Signaling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Membrane Protein Biogenesis: Director's Cut
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Structural Insights Into Fungal ER Membrane Protein Biogenesis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Primed with Ubiquitin: A Failsafe Mechanism for Membrane Protein Insertion into the ER"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Enhanced Time-Resolved Interactome Profiling to Resolve Secretory Protein Quality Control Dynamics"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Chaperone Role of Calmodulin in Co-Translational Protein Folding"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Role of the Lipid Environment on the Structure, Function and Dynamics of the GLUT1 Transporter"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Characterization of SARS-CoV-2 Membrane Protein Biogenesis in Live Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Nascent Chain-Mediated Ribosomal Frameshifting During Membrane Protein Translation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Therapeutic Developments for Rescuing Membrane Protein Misfolding
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:40 pm
"Targeted Ubiquitination/Deubiquitnation of Ion Channels for Therapy"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
"Dynamic Interactions During Membrane Protein Folding Revealed by Interactomics"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
"Small Molecule Modulation of PMP22 Expression and Trafficking"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"High-quality Glucagon Receptor (GCGR)/G-Protein Complex: Optimizing Expression and Purification to Expedite Cryo-EM Structural Studies"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure