Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Brain Matters: Membrane Transporters in Glia and Their Relationship to Disease
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"The Split Personality of Glutamate Transporters: A Chloride Channel and a Transporter"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Astrocytic Glutamate Transport, Mitochondria, and Calcium: What's a Little Energy Among Friends?"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"VGLUT3 in Parkinson's Disease"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Endosomal pH as Therapeutic Target for Neurological Disorders"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Insights into Transporter Function: State-of-the Art Approaches
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Monitoring Conformational Dynamics upon Ligand Binding in Neurotransmitter:Sodium Symporters"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Nanopharmacological Force Sensing Reveals Two Ligand Binding Sites in Monoamine Transporters"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Single-Molecule Approaches to Monitor Conformational Dynamics in ABC Transporters"
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
"Single Molecule Measurements Catch Transporters 'Taking a Break': On the Crucial Importance of Off-Cycle States for Function and Regulation"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Computer-Aided Drug Design Targeting Human Solute Carrier Transporters"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Presynaptic Gq-Coupled Receptor Activation Drives D2-Dependent, Biphasic Dopamine Transporter Surface Trafficking"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Quantum Dots Reveal Differential Membrane Compartmentalization of Dopamine Transporter and Dopamine D2 Autoreceptor"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Protein Trafficking: Chaperoning Services
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Differential Regulation of Dopamine Transporter Activity in the SN and VTA"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Nucleoside Transporters: New Modalities of Regulation and Therapeutics"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Cognate Ligand Chaperoning: A Novel Proteostatic Mechanism?"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Discovery of CFTR Modulators for the Treatment of Cystic Fibrosis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Plasma Membrane as a Regulator of Transport
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"How Lipids Shape Proteins Oligomers: A Case Study Using Single Molecule Microscopy"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Reciprocal Regulation Between TRPV1 and PI3K: Role in Inflammatory Sensitization"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Energetics of Protein-Lipid Interactions"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Membrane Environment of DAT Plays a Critical Role in Promoting AMPH-Induced Efflux of DA Through DAT"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Phosphatidylinositol (4, 5)-Bisphosphate Coordinates Functional Interactions in the Dopamine Transporter to Promote Amphetamine Behaviors"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Evidence for Dopamine Transporter Dysfunction in Autism Spectrum Disorder"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Para-Substituted Methcathinones as Selective and Unselective Inhibitors of Human Dopamine and Serotonin Transporter"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Structural Basis for Cooperativity in Dimeric SLC26 Transporters"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sex as a Biological Variable in Transport Processes
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Membrane Transporter Function in the Human Placenta and Their Role in Pregnancy Complications and Life Long Health"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Estrous Cycle-Dependent Alterations in Stimulant Actions at the Dopamine Transporter Underlie Enhanced Cocaine Reward in Females"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Sex Differences in Redox Environment and Neuronal Morphology Occur in Association with Enhancement of Excitability in System xc-Null Mice"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Sex Differences in Renal Transport Processes Regulated by Insulin and/or Insulin-Like-Growth Factors"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transporters in the Brain and Their Role in Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Dissecting the Many Roles of the Dopamine Transporter in the Regulation of Psychostimulant Addiction"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"G Protein Modulation of the Dopamine Transporter and the Actions of Amphetamine"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Modeling Heritable Human Dopamine Transporter Dysfunction"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Defective Zinc Transport as an Etiology of Autism"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Cerebro Spinal Fluid Production: We Know So Much and Understand So Little; Cotransporters as the Missing Link?"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Striatal Neurons Regulate VGLUT2 Expression and Topography in Dopamine Neurons"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Dual and Direction-Selective Mechanisms of Phosphate Transport by the Vesicular Glutamate Transporter"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transporters in Disease: CFTR and ABC-Transporters
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Interactions and Cooperativity Between P-Glycoprotein Structural Domains Determined by Thermal Uncoupling and LRET"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Structural Mechanisms of KATP Channelopathies"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"High-Speed Atomic Force Microscopy: Dynamics of Single Membrane Transporters and Channels in Membrane and Without Labels"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Biosynthetic Alterations and Correction in ABCC Proteins: Lessons Learned form CFTR and ABCC6"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Diabetes and Beyond: Transporters Are Key
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Glucose Transport and Metabolism in Obesity and Diabetes"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Hidden Metabolic Costs of Synaptic Transporters: Staying Ready for Action Is Expensive"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Chloride Transporters in B-Cell Physiology"
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
"Regulation of GLUT4 Dynamics by Ankyrins: Implications for Metabolic Flux and Diabetes"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Needle in a Haystack: Threading the Link Between SLC16A11 and Type 2 Diabetes"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Leptin Signals via a Novel Mechanism to Activate PKA for KATP Channel Trafficking to Suppress Insulin Secretion from Pancreatic B-Cells"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Sweet Oscillations: Transporter Measurements In Vitro and In Vivo Using a Novel Genetically-Encoded Biosensor for Glucose"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Keynote Session: Transporters and Channels
5:30 pm - 5:35 pm
Introduction by Discussion Leader
5:35 pm - 6:05 pm
"Genomewide and Evolutionary Studies Reveal Transporters as Determinants of Metabolic Disorders"
6:05 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
"4-Phenylbutyrate Corrects Folding-Deficient Creatine Transporter-1 Variants Associated with the Creatine Deficiency Syndrome"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Structural Basis for Ibogaine Inhibition of hSERT Revealed by Single Particle Cryo-EM"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:15 pm
"Voltage Sensors and Membrane Capacitance"
7:15 pm - 7:25 pm
Discussion
7:25 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure