Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Channelopathies and Transportopathies
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"Decrypting Variants of Unknown Significance in the Channelopathies Using Automated Patch Clamp"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Ins and Outs of the Na, K-ATPase"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Disassembly and Assembly of Nuclear Pore Complex and Nuclear Transport in Neurodegeneration"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Heating Things Up: a Mitochondrial Transporter that Thinks it’s a Channel"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Targeting Transporters for Pharmacotherapies
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 10:05 am
"The Sodium/Iodide Symporter (NIS): An Unending Source of Surprises"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Novel and Atypical DAT Inhibitors for the Treatment of Psychostimulant Use Disorders"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Mechanisms of Transport of LAT Transporters"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Mechanism of Bioactive Lipid Inhibition of Glycine Transporters"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Regulation of a Neuronal Glutamate Transporter by Methamphetamine"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Transporter Function and Dysfunction in Metabolism, Diabetes and Obesity
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Novel Roles for VGLUT2 in Health and Disease: From Flies to Humans"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Breaking the ZIP Code - a New Player in B Cell Development"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Glucose Uptake Mechanisms in Muscle and the Endothelial Barrier"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"The Mitochondrial Transporter SLC25A25 Links Ciliary TRPP2 Signaling and Cellular Metabolism"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Invertebrates as Animal Models to Study Transporter Functions
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 10:05 am
"Close Encounters: the Intimate Regulatory Relationships Between GPCR Signaling and Neurotransmitter Transporters"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Role of Glial Enriched Ion Channels and Transporters in C. Elegans Sensory Behaviors"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Remembering the Past to Prepare for the Future: the Long-Term and Inherited Effects of Amphetamine at the Monoamine Transporters"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"New Drosophila Neuromodulatory Circuits to Probe Neurotransmitter Transporter Activity"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Syntaxin1 Ser14 Phosphorylation is Required for Non-Vesicular Dopamine Release"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Na, K-ATPase and Related Pumps
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:25 pm
"Quantifying Secondary Transporter Activity at Single-Molecule Resolution"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Na, K-ATPase Brain Isoforms, AHC Neurological Disease Mutant"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Fundamentals and Importance of the SLC Solute Carrier Superfamily: the New SLC Atlas"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neurological and Neuropsychiatric Disorders: Transporters at Play
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Regulated Dopamine Transporter Trafficking: Novel Mechanisms and Physiological Impact"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"The Dopamine Transporter Antiports Potassium to Increase the Uptake of Dopamine"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Behavioral Encoding Across Timescales by Region-Specific Dopamine Dynamics: Is it all about DAT?"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Novel Psychoactive Substances: Exploiting Rogue Chemicals as Therapeutic Scaffolds"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Structural Basis of GABA Reuptake Inhibition"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Systematic Characterization of Human Dopamine Transporter Missense Mutations from a Danish Cohort of Psychiatric Patients"
12:05 pm - 12:10 pm
Discussion
12:20 pm - 12:40 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Strategies, Ideas and Techniques to Study Membrane Protein Structure-Function and Trafficking
6:00 pm - 6:20 pm
"Membrane Responce to Domain Movements in a Glutamate Transporter Homologue"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Lipid-gated Monovalent Ion Fluxes in the Control of Endocytic Traffic"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Histamine Transport: a Novel Antidepressant Strategy"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Catch Me If You Can: Transport and Chaperone Machineries in Adaptive Immunity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Peptides, Hormones, and Neurotransmitter Release: The Importance of Transporters in the Gut and Brain
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Integration of Vesicular Glutamate Transport into the Synaptic Vesicle Cycle"
9:30 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Neuroendocrine Functions of Steroid Hormone Transporters - Lessons from Fruit Fly Research"
9:55 am - 10:05 am
Discussion
10:05 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Decoding the SLC Supergroup by Large-Scale Assessments and Deep Learning"
10:50 am - 10:55 am
Discussion
10:55 am - 11:15 am
"Mechanism for Microbial Regulation of Psychostimulant Abuse"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
"dTRPA1 May be a Candidate Receptor for a Novel Optogenetic Method Based on X-rays Instead of Visible Light"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Critical Roles of Sphingosine-1-Phosphate Transporters for the Vasculature"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Detailing Mechanisms of Importers and Exporters
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Structure-Function Studies of ENaC"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:50 pm
"Inhibition of the ABCG2 Membrane Transporter by Pesticides"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
"Conformational Dynamics of a Neurotransmitter: Sodium Symporter Homolog"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
7:30 pm - 7:40 pm
Discussion
7:40 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure