Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Molecular Mechanisms of the Blood-Brain Barrier
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"How Does the Blood-Brain Barrier Regulate Brain Function and Behavior?"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"Structural Basis for Substrate Polyspecificity in Multixenobiotic ABC Transporter Zebrafish Abcb4"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Proton-Driven Alternating Access and Broad-Specificity in Spns Lipid Transporters"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Structural and Molecular Basis of Choline Uptake into the Brain by FLVCR2"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Plant, Microbe and Pathogen Transporters
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Mechanism of a Checkpoint Flippase Controlling Teichoic Acid Translocation in Pneumococcus"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Navigating the Ins and Outs of the Transport Cycle"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Structural Characterization of P55, a Transporter in M. Tuberculosis "
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Engineering Transport Proteins for a Sustainable and Productive Future"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Real-Time Observation of Substrate Translocation Dynamics in an ABC Transporter"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Beyond Membrane Transport Proteins Structure: Insights into Dynamics from H/D Exchange Coupled to Mass Spectrometry"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Mechanisms of Pumps and Channels
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"When Ammonium Transporters Become Receptors"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Calcium Dysregulation in Amyotrophic Lateral Sclerosis"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"In-Silico Discovery of Functionally Selective Glutamate Transporter Inhibitors"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Native Muscle ACh Receptor Structure in Developing Synapses"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Structural Insights into the Rotational Dynamics and Regulatory Mechanisms of F1Fo ATP Synthase"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Brain Transporters in Health and Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Functional Impact of Patient-Derived Variants of EAAT1/SLC1A3, a Dual-Function Glutamate Transporter/Chloride Channel Involved in Episodic Ataxia"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"The Molecular Basis for Cocaine Binding to the Human Dopamine Transporter"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Medial Prefrontal Cortex Serotonin Dynamics in Social and Socio-Cognitive Processes"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Stimulant Effects on the Dopamine System are Sexually Dimorphic and Sensitive to Ovarian Hormone Cycles"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Organic Cation Transporter 3: A Crucial Player in the Actions of Alcohol and Amphetamine"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Bacterial Biofilms as Key Participants in Amphetamine Use Disorder"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Conformational Dynamics of a Mammalian Glutamate Transporter"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Insights into Substrate and Inhibitor Recognition in GABA Reuptake Machinery"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unconventional Transporters: Elevators, Dual Function, and Hybrid Transporters
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Reaction Cycle of the Sodium-Dependent Carboxylate Transporters"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Identification and Characterization of a Novel Substrate Binding Protein-Dependent Transporter from the Re-Emerging Human Pathogen Bordetella pertussis "
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"TTYH Proteins as Catalysts of Lipid Transfer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Structure and Mechanisms of Transport of Human Asc1/CD98hc Amino Acid Transporter"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transporters of Anions, Cations and Metals
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Mechanism of ClC-7 Inhibition by Lysosomal Phosphoinosides"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Conformational Cycle and Substrate Selectivity in Nramp-Family Metal Transporters"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Regulation of ABC Transporters by Phosphorylation in Intrinsically Disordered Regions"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Structure and Mechanism of Oxalate Transporter OxlT in an Oxalate-Degrading Bacterium in the Gut Microbiota"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Sub-Second Release of Neurotransmitters from CD4+ T Lymphocytes"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Novel Structural Insights into the Mechanism by Which the Q72A Na+/I- Symporter (NIS) Mutant Binds and Transports Na+ and Oxyanions"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"The Structural and Mechanistic Determinants of Bacterial Manganese Import"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transporter Drug Discovery: Perspectives from Pharma and Industry
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Unlocking Solute Carrier Drug Discovery by Cell-Based Technologies"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Discovery and Characterization of JNT-517, an Inhibitor of SLC6A19 for the Treatment of Phenylketonuria"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"From Molecules to Medicines: Advancing Small Molecule Drug Discovery for Solute Carriers with Mass Spec and Cryo-EM"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"A Structural Understanding of Allosteric Inhibition of SLC6 Amino Acid Transporters"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Transporter Function and Dysfunction in Metabolism, Obesity and Cancer
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Methotrexate Recognition by the Human Reduced Folate Carrier SLC19A1"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Fluorescent Cell-Based High-Throughput Screening to Identify MCT4 (SLC16A3) Inhibitors"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Redefining the Mechanism of Action of Chemical Uncouplers for a New Generation of Antiobesogenic Drugs"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Structural Basis of Inhibition and Transport in Human Organic Cation Transporter 1"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Mitochondrial Transporters and the Control of Cellular Metabolism"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Harnessing Computational Methods to Target Nutrient Transporters"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Innovative Approaches to Study Membrane Transporter Function
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Hydrolytic Regulation of Neuronal Activity and Behaviors by Non-Invasive Xray Technology"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"In vitro Platforms to Study and Deploy Membrane-Associated Proteins"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"A Million to One Shot? A Novel Approach to Identifying Regulators of Dopamine Signaling, Transport and Drug Action"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure