Metals in Biology

Gordon Research Conference

January 18 - 23, 1998
Chair
Vice Chair
Four Points Sheraton / Holiday Inn Express
1050 Schooner Drive
Ventura, California, United States
 Venue and Travel Information

Related Meeting

This GRC will be held in conjunction with the "Bioinorganic Chemistry" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

BIOINORGANIC CHEMISTRY AND BIOGEOCHEMICAL CYCLES

Chair, Ken Karlin (Johns Hopkins U.)
  • Ed Stiefel (Exxon Company) - Bioinorganic chemistry and biogeochemical cycles

IRON SULFUR CLUSTERS

Chair, Marc Walters (New York U.)
  • Dimitri Coucouvanis (U. Michigan) - Partial structural analogs for the nitrogenase cofactor and their catalytic function in the reduction of various nitrogenase substrates
  • Barbara Burgess (UC Irvine) - The mechanism of Ferredoxin I mediated regulation of NADPH:ferredoxin reductase in Azotobacter vinelandii
  • Lance Seefeldt (Utah State U.) - Electron transfer reactions and MgATP hydrolysis in nitrogenase catalysis
  • Joan Broderick (Amherst College) - Pyruvate formate lyase activase: Radical generation by an Fe-S Cluster

ZINC PROTEASES

Chair, Jim Canary (New York U.)
  • Carl Decicco (Dupont Merck) - Zinc metalloproteinases and drug discovery
  • Rick Holz (Utah State U.) - Mechanistic studies on peptide hydrolysis by dinuclear metalloenzymes

METAL REGULATION AND PROCESSING

Chair, Philip Aisen (Albert Einstein College of Medicine)
  • Richard Palmiter (HHMI; Seattle) - Vesicular zinc
  • Tom O'Halloran (Northwestern) - Getting metal ions to the right place in the cell: chaperone proteins and vesicles
  • Bob Hausinger (Michigan State U.) - Nickel incorporation into urease
  • Jerry Kaplan (U. Utah) - Yeast mitochondrial iron metabolism: Insights into human disease

MEDICINE AND DIAGNOSTICS

Chair, Luigi Marzilli (Emory U.)
  • Steve Lippard (MIT) - On the biological mechanism of cisplatin
  • Tom Meade (Cal Tech) - New MRI agents; monitoring gene expression in vivo

PEROXYNITRITE AND NITROGEN OXIDE BIOLOGY/CHEMISTRY

Chair, Bob Scheidt (U. Notre Dame)
  • Mike Stern (Monsanto Company) - Peroxynitrite decomposition catalysts. Novel Therapeutics for peroxynitrite-mediated pathology
  • John Groves (Princeton U.) - Biological targets of peroxynitrite. Redox pathways, mechanism and membrane permeability
  • Peter Kroneck (U. Konstanz, Germany) - Nitrous oxide reductase, a copper enzyme with novel chromophores
  • Mike Marletta (HHMI; U. Michigan) - Piecing together cofactors and mechanism in nitric oxide synthase

PHYSICAL STUDIES ON ELECTRON TRANSFER CENTERS

Chair, Jacques Meyer (CEA-Grenoble, France)
  • Jacques Meyer (CEA-Grenoble, France) - Monitoring structural changes in iron-sulfur active sites
  • Eckard Münck (Carnegie-Mellon U.) - On the nature of the A- and C -clusters of CO dehydrogenase
  • Claudio Luchinat (U. Florence, Italy) - Ferredoxins and cytochromes: beyond the solution structure

DIOXYGEN PROCESSING/O2-ACTIVATION

Chair, Dan Stack (Stanford University)
  • Dan Stack (Stanford University) - Catalytic functional model of galactose oxidase
  • Ninian Blackburn (Oregon Grad Inst.) - Peptidylglycine alpha-hydroxylating monooxygenase: Structure and mechanism.
  • Chris Schofield (Oxford U., UK) - Structures and mechanisms of non-heme iron oxygenases
  • Anne-Francis Miller (Johns Hopkins U.) - The basis for metal ion specificity in Fe- and Mn-superoxide dismutase
  • John Caradonna (Yale U.) - Interactions of reduced dioxygen species with non-heme iron centers: from synthetic models to proteins

BIOINORGANIC DISEASE STATES
(Joint Session with Gordon Research Seminar)

Chair, Ken Karlin (Johns Hopkins U.)
  • Joan Valentine (UCLA) - Searching for the link between Cu-Zn superoxide dismutase and ALS

Contributors

Bristol-Myers Squibb Co.
DuPont Merck Pharmaceutical Co.
EPIX Medical, Inc.
Exxon Research & Engineering Co.
Gordon Research Conferences
Mallinckrodt Medical, Inc.
Merck & Co., Inc.
Monsanto Co.
National Institute of General Medical Sciences (NIGMS-NIH)
Nickel Producers Environmental Research Association (NiPERA)
Pharmacyclics, Inc.
Roche Bioscience
The Society of Biological Inorganic Chemistry (SBIC)
Strem Chemicals Inc.
Unilever Research U.S., Inc.

Conference Links

Conference History Bioinorganic Chemistry (GRS)
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