Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"X-Ray Microscopy for Detection of Metals in Cells and Tissues"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Chelation Modeling of a Plutonium-238 Inhalation Incident Treated with Delayed DTPA"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Advanced Development of the Actinide Decorporation Agent HOPO 14-1"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Clinical Advances for Metals in Medicine
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:50 am
"Clinical Development of BOLD-100, a Ruthenium-Based Therapeutic Currently in Phase 2 Studies for the Treatment of Advanced Gastrointestinal Cancers"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Highly Cytotoxic Naphthoquinone Derived N,O,O-Tridentate Organometallics as Potential Anticancer Agents"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:30 am
"Imaging and Therapy with Metal Radionuclides"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Affinity-Based Recognition of Tetravalent Zr-89/Th-227 Theranostic Pair by Siderocalin Trastuzumab Fusion Protein"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stimuli-Responsive Metallodrugs as Emerging Therapeutics
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Utilization of the Photophysical and Photochemical Properties of Transition Metal Complexes for the Design of Bioorthogonal Imaging Reagents and Photosensitizers"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"Ruthenium-Based Photoactivated Chemotherapy in Vivo"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Siderophore-Linked Ruthenium Catalysts for Targeted Allyl Ester Prodrug Activation within Bacterial Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Exploring Chemical Space for Iridium Photosensitizers"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Metal-Based Therapeutics for Infectious Diseases
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Leveraging Combinatorial Synthesis to Discover Novel Metalloantibiotics"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Rational Design of Metal-Containing and Metal-Binding Antimicrobial Agents"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Gold-Based Compounds as Selective Anti-Leishmanial Metallodrugs"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Structural Insights into the Sensing of Iron Nutrients as a Basis for the Development of New Drugs"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Lighting-up Iridium AIEgens for Antimicrobial Therapy"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Addressing Health Disparities and Increasing Diversity and Inclusion in Biomedical Research
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Resolving Race vs Ancestry in Cancer Disparities Research – The DARC Side of Breast and Prostate Cancer"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Advancing Equity and Inclusion in STEM Research: Strategies for Student Recruitment and Engagement"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Setting the Table for Inclusive Excellence in Science: A Chair’s Perspective"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Addressing Disparities in Diagnostic Imaging in Africa"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Drug Delivery and Targeted Therapies
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Exploiting Specific Characteristics of Malignant Tissue for Anticancer Therapy"
9:40 am - 9:50 am
Discussion
9:50 am - 10:15 am
"Controllable Activation and Delivery of Platinum Anticancer Prodrugs"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Imaging Immune Response to Targeted Therapeutic Interventions"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Synthesis of Graphene Oxide Loaded Copper(II) Complexes for Cancer-Targeted Therapy: Evaluation of Binding with Target tRNA, In Vitro Cytotoxicity and In Vivo Genotoxic Potency"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Cisplatin Prodrug Loaded Engineered Nanomaterials in Pursuit to Manage Aggressive Cancers"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Mode of Action Deconvolution in Metallodrug Discovery"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Disrupting Tumor Immune Evasion: Copper Chelation as a Promising Intervention Strategy"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Exploring Transferrin and Small Molecule Chelator Regulation of Titanium(IV) Bioactivity"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Unconventional Metal-Based Therapeutics
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Mitochondrial Ion Channel Inhibitors as Cytoprotective Agents"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Towards the Development of Anti-Cancer Stem Cell Metallopharmaceuticals"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Understanding the Anticancer Intracellular Modes of Action of Vanadium Compounds"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Insights into the Mechanism of Action of Anticancer G Complexes"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Treating Tumor Metastases Using Immunogenic Cell Death Inducing Metal Complexes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Clinical Experience with Theranostics: The Expansion to Radiometals"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"The Integrin Alpha v Beta 6 as a Target for PRRT"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Chelation of Radiometals for Incorporation into Theranostic Radiopharmaceuticals"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure