Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Phage and Predator Stress
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Sensing and Responding to Phage Infection"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Architecture and Infection-Sensing Mechanism of the PARIS Antiphage Defense System"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Using Transposon-Sequencing to Assess Phage Gene Contributions for Fitness in the Virulent Phage ICP1 during the Predation of Vibrio cholerae "
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Toxic Antiphage Defense Proteins Inhibited by Intragenic Antitoxin Proteins"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"Anti-Phage Immune Systems in Staphylococci"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Systems Approaches to Understand Stress Responses
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Coordination of Protein Degradation and Synthesis Underlies Resource Allocation in Starving Bacteria"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Bioenergetic Stress in Antimicrobial Resistance and Persistence"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
"Multiplexed Image-Based Screening of the Bacterial Essentialome Reveals Mechanisms of Growth-Division Coordination"
10:05 am - 10:10 am
Discussion
10:10 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Using Stress Responses to Unravel Bacterial Gene Function"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
"A Targeted Genome-scale Overexpression Platform for Proteobacteria"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"A Phosphosubstrate Sequence-Function Map Enables Tuning of Bacterial Hanks-Type Ser/Thr Kinase Activity with Quantitative Precision"
11:45 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"M3-Seq: Bacterial Single Cell RNA Sequencing Reveals Novel Stress Responses"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Role of Small Molecule Regulators in Stress Response
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Small Molecule Regulators in Bacteria"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"Pulsatile Flagellar Gene Expression Drives the Dynamics of c-di-GMP Levels in Single Bacterial Cells"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
"Cyclic-di-AMP Controls Cellular Turgor in Response to Defects in the Cell Wall"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Synthetase and Hydrolase Specificity Collectively Excludes 2’-Deoxyguanosine from Bacterial Alarmone"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Themes and Variations of Stress Signaling by Alarmones"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Folding and Degradation During Stress
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Lon-Mediated Proteolysis in Bacterial Stress Adaptation"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"The Control of Protein Arginine Phosphorylation Facilitates Protein Homeostasis by an AAA+ Chaperone Protease System in Bacillus subtilis "
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
"Regulation of the Essential Transmembrane AAA+ Protease FtsH"
10:05 am - 10:10 am
Discussion
10:10 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Post-Translational Mechanisms of Stress Response in Archaea"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Structural Basis for Regulation of RpoS Turnover by Phosphorylation and ClpXP Anti-Adaptors"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Modulating the Sigma Factor RpoS Response and Recovery from Stress in Escherichia coli "
11:45 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"The Periplasm has FevR: Discovery of a Transcriptional Factor that Compensates for the Lack of DegP"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translation and Ribosome Quality Control During Stress
7:30 pm - 7:55 pm
"Translational Quality Control in Bacteria"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"The Genomic Variation of Release Factor 2 Autoregulation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"tRNA Queuosine Modification Reprograms Translation in Response to Antibiotics in Vibrio cholerae "
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Why Bacteroidia Ribosomes Tuck in Their Tails"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Ribosome Rescue in Bacterial Stress"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"(p)ppGpp-Dependent Transcriptional Activation During Transition to Quiescence"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stress at Multiple Spatial Scales: Cell-Cell Interactions, Biofilms and Cell-Surface Interactions
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Regulatory Mechanisms Controlling Biofilm Formation in Vibrio Cholerae"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Spo0A~P Oscillatory Dynamics are the Primary Cause for Biofilm Matrix Deactivation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Spatiotemporal Organization of Programmed Cell Ceath in P. aeruginosa Biofilms"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"Fattening Up When Starved: Carbonosome Dynamics in Non-Growing Pseudomonas aeruginosa "
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
"Revealing the Heterogeneity of Pseudomonas aeruginosa Biofilms Using Single-Cell, Probe-Based RNA Sequencing"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Sudden Nutrient Starvation Induces a Unique Morphological and Metabolic Profile"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"A Large and Ancient Bacterial Noncoding RNA Enables Adaptation to Various Stresses"
11:45 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Interspecies Interactions Influence Bacterial Fitness and Behaviors"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Replication and Transcription During Stress
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Bacterial RNP-Bodies Promote Adaptation to Cell Stresses"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"The Transcriptional Response to Low Temperature is Weakly Conserved Across the Enterobacteriaceae"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
"Phosphoarginine Modulates ClpC2 Oligomerization and Transcriptional Activity in Mycobacterial Stress Pathways"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Metabolic Insight into Pseudomonas aeruginosa Fluoroquinolone Sensitivity and Persistence"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"An Epigenetic Mechanism for Oxidative Stress Resistance in the Archaeon Sulfolobus islandicus "
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Environmental Stress Responses
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:25 am
"Shear Rate Sensitizes Bacterial Pathogens to H2O2 Stress"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Elucidating the Mechanism of Hemerythrin in Pseudomonas aeruginosa Fitness Under Microoxic Stress"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"The Role of Membrane Potential in Oxygen Stress Response"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Another Brick in the Wall: SlyB Compartmentalizes the Outer Membrane Proteome into Stress-Induced Lipid Nanodomains"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"The Stomatin-Like Protein StlP Organizes Membrane Microdomains to Govern Polar Growth in Filamentous Actinobacteria Under Hyperosmotic Stress"
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:15 am
"H-NS Condensation Implies the Involvement of Phase Separation in Bacterial Heterochromatin Formation"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"E. coli Survival During Prolonged Starvation Depends on a Phosphohistidine Phosphatase that Regulates Nucleoside Diphosphate Kinase"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"The Overlooked Proteome Modulating Bacterial Signaling Pathways"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stress of Host-Pathogen Interactions
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Compensatory Evolution in NusG Improves Fitness of Drug-Resistant Mycobacterium Tuberculosis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"Visualization of Non-Replicating Persisters of Mycobacterium tuberculosis in Lung Lesions"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
"The Conserved c-di-AMP-Binding Protein PstA Requires the Cytochrome bd Oxidase to Regulate Beta-lactam Resistance in Listeria monocytogenes "
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Bile Acid Sensing Mechanisms in Clostridioides difficile "
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure