Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Lessons From Bacterial Pathogens
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:05 pm
"The Discovery of Macrophage Genes That Damage the Staphylococcal Cell Wall and Control Bacterial Replication"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Metabolic-Epigenetic Axis in Microglia Development and Activity"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"The Intersection of Bacterial Metabolism, Pathogenesis, and Innate Immunity"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Bacterial Warfare and Host Resistance
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Elucidating Mechanisms of Tolerance to Salmonella & Staphylococcal Infection Using the Collaborative Cross"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Why Rifampicin Works for Staphylococcal Biofilm Infection"
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
"Endogenous Retroviruses Control Inflammatory Responses During Escherichia Coli Bloodstream Infection"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Group Photo / Coffee Break
11:05 am - 11:30 am
"Immunity, Infection and the Circadian Clock"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Klebsiella Pneumoniae and Blood Vessels: A New Battleground Controlled by the T6SS"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Ecological Diversification Reveals Paths of Pathogen Emergence"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Manipulation of Human Innate Immunity by Neisseria Gonorrhoeae "
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Stepwise Pathogenic Evolution of Bacteria"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbial Defenses: Toxins and Immunity
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Island Exploration for Vibrio Cholerae Phage Defense"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Cell-Cell Antagonism in Pathogenic Burkholderia "
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
"An Ubiquitous Toxin From Human Gut Commensals Promotes Neonatal Competitive Advantage"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Pore Outcomes: Pneumolysin-Dependent Damage During S. Pneumoniae Infection"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Heterogeneity of Salmonella Enterica Lipopolysaccharide Counteracts Innate Immune Defenses"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolic Regulation of Virulence and Host Responses
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Metabolic Crosstalk During Host-Pathogen Interactions"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Cholesterol Metabolites and TB Pathgenesis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Airway Metabolites Drive Selection of Pathogens That Cause Persistent Pneumonia"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Intracellular Battleground
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Bacterial Escape From Interferon-Regulated Cell-Autonomous Immunity"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Control of Host Nuclear Proteins by Brucella Effectors"
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
"A Coxiella Burnetii Effector Defines a Family of Bacterial Deubiquitinases"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Interferon: Tug of War Between Host and Pathogen"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"TNF and Type I IFN Induction of the IRG1-Itaconate Pathway Restricts Coxiella Burnetii Replication Within Mouse Macrophages"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Pathogenesis and the Microbiome
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Cross-Kingdom Interactions: How Gut Fungi Promote Salmonella Virulence"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"An Obligate Anaerobic Pathogen Rewires Gut Epithelial Metabolism to Respire in the Inflamed Gut"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Reprogramming of the Neonatal Gut by an Enteric Pathogen"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Metals, Microbes and Nutritional Competition
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Importance of Methylglyoxal Detoxification and Nutritional Immunity to Group B Streptococcal Survival in the Diabetic Wound"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Ferrosome Organelles in Clostridioides Difficile: Biogenesis and Impact on Host-Microbe Interactions"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Iron and Infection Infidelities"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Nutritional Immunity Regulates Interspecies Interactions in the Respiratory Tract"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Role of Ethanolamine Utilization and Bacterial Microcompartment Formation in Listeria Monocytogenes Intracellular Infection"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Microbes and Complex Determinants of Disease
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"Nitric Oxide Tunes the Activity of Natural Antibiotics"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"Metabolic Reprogramming of the Host Epithelium Drives Pathogen Outgrowth During Vaginal Dysbiosis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"Deciphering Defense Systems of 7th Pandemic Vibrio Cholerae "
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure