| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Immunity and Host Defense |
| Discussion Leaders: Ine Jorgensen (UNC-Chapel Hill) and Kristen Lokken (UC-Davis) |
| 3:45 pm - 4:00 pm | Simon Döhrmann (UC-San Diego)
"A Function for High-Density Lipoprotein in Innate Immune Defense Against Invasive Group A Streptococcal Infection and the Pathogen's Counterattack"
|
| 4:00 pm - 4:10 pm | Discussion |
| 4:10 pm - 4:25 pm | Danielle Pilla (Duke University)
"Guanylate Binding Proteins Promote Caspase-11 Dependent Pyroptosis in Response to Cytoplasmic LPS"
|
| 4:25 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Host-Pathogen Interactions |
| Discussion Leaders: Katherine Price (Geisel School of Medicine at Dartmouth) and Shumin Tan (Cornell University) |
| 7:30 pm - 7:50 pm | Juan Hernandez-Doria (UT-Southwestern)
"The Shiga Toxin (Stx2) Production by EHEC in the Human Gut Can Be Influenced by Diet and Commensal Bacteria"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Fabian Rivera-Chavez (UC-Davis)
"Salmonella Uses Energy Taxis to Benefit from Intestinal Inflammation"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Melissa Farrow (Vanderbilt University Medical School)
"Clostridium difficile Toxin B-Induced Necrosis Is Mediated by the Host Epithelial Cell NADPH Oxidase Complex"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Vidhya Nair (UT-Southwestern)
"Microfold Cells Are a Critical Site of Entry and Dissemination by Mycobacterium tuberculosis"
|
| 9:20 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Mechanisms of Pathogenesis |
| Discussion Leaders: Michelle Reniere (UC-Berkeley) and Zack Abbott (University of Michigan) |
| 9:00 am - 9:20 am | Cara Mozola (Washington University)
"A Novel Cholesterol-Insensitive Mode of Membrane Binding by Streptolysin O Promotes Cytolysin-Mediated Translocation of the Co-Toxin SPN"
|
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Sloan Siegrist (UC-Berkeley)
"Coordinate Regulation of Virulence and Cell Wall Dynamics by an Intracellular Pathogen"
|
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Kevin Hicks (University of Washington)
"Restricting Conformational Flexibility in the PhoQ Sensor Kinase Separates pH and Antimicrobial Peptide Recognition"
|
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Matthew Surdel (Vanderbilt University)
"Bacterial Nitric Oxide Synthase Is Required for the Staphylococcal Heme Stress Response"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:40 pm | Acquisition of Nutrients by Pathogens |
| Discussion Leaders: Olga Danilchanka (Harvard Medical School) and Steven Siegel (University of Pennsylvania) |
| 1:30 pm - 1:50 pm | Kimberly Davis (Tufts Medical School)
"Community Behavior of Y. pseudotuberculosis Within Microcompartments in Host Tissue"
|
| 1:50 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:20 pm | Matthew Barber (University of Utah)
"Iron Piracy Drives Dynamic Evolution of Primates and Bacterial Pathogens"
|
| 2:20 pm - 2:30 pm | Discussion |
| 2:30 pm - 2:40 pm | Concluding Remarks: Andrew Olive (University of Massachusetts Medical School) and Sarah Clark (University of Colorado Denver) |
| 2:40 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
