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Mitochondria in Health and Disease

Gordon Research Conference

Mitochondria Biology

February 5 - 10, 2023

Chairs

and

Vice Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

The Mitochondria in Health and Disease GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Mitochondrial Energy Metabolism and Redox Regulation Discussion Leader:
7:40 pm - 7:55 pm	Introduction by Discussion Leader
7:55 pm - 8:15 pm	"Futile Creatine Cycle: Mechanisms and New Biology"
8:15 pm - 8:25 pm	Discussion
8:25 pm - 8:45 pm	"Mitochondrial Muscle Disease: A Metabolic Pellagra"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	"Noninvasive Treatment of Brain Ischemia-Reperfusion Injury with Near Infrared Light Using Waveguide Technology"
9:15 pm - 9:25 pm	Discussion
9:25 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Mitochondrial Genome Maintenance and Editing Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Structural Insights of Mitochondrial DNA Replication in Disease"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Potential Therapeutic Uses of DNA Editing Enzymes for Mitochondrial Diseases"
10:05 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"ADP-Ribosylation for the Maintenance of Mitochondrial Homeostasis"
11:05 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Identifying Novel Mitochondrial Stress Response Factors Using Targeted Doxorubicin (mtDox) in Tandem with CRISPR/Cas9 Whole Genome Screening"
11:25 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Fumarate Accumulation Triggers mtDNA Release to Induce Inflammation"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Single-Nucleoid Architecture Reveals Heterogeneous Packaging of Mitochondrial DNA"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: , and
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Mitochondrial Protein Biogenesis Discussion Leader:
6:00 pm - 6:15 pm	Introduction by Discussion Leader
6:15 pm - 6:35 pm	"Control of Mitochondrial Protein Import"
6:35 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	"MTCH2 is a Mitochondrial Outer Membrane Protein Insertase"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"You Take The High Road and I Take The Low Road - Unconventional Routes for Protein Targeting to Mitochondria"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"UPRmt and mtDNA Replication in Mitochondrial Disease"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Proteostasis Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Autophagy, Mitophagy, and Inflammation"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Mapping a Common Pathway for Parkinson’s Disease Proteins in Cell Survival and Immunity"
10:05 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Proteolytic Rewiring of Mitochondria at the Interface of Inflammation and Cell Death"
11:05 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Parkin, Mitophagy, and Dopaminergic Neuron Stability in the Mammalian Brain"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Mitochondrial Health Maintenance in Neurons"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	"Mitochondria. Location Matters"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"An Optineurin-Dependent Retrograde Transit Filter in Distal Axons Mediates Mitochondrial Quality Control in Synapses"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Interorganellar Crosstalk Discussion Leaders:
6:00 pm - 6:15 pm	Introduction by Discussion Leader
6:15 pm - 6:35 pm	"Metabolic Signals in Bacteria-Mitochondria Communication"
6:35 pm - 6:45 pm	Discussion
6:45 pm - 7:05 pm	"Unbiased Screenings Reveal Regulators of Mitochondrial Dynamics and Contact Sites"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"Altered MAM Function Shifts Mitochondrial Metabolism in SOD1-Mutant Models of ALS"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"The Mitochondrial Sites of Contact with the Nucleus: Regulation and Function"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Mitochondria and Metabolic Regulation Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Mitochondria as Signaling Organelles"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Macrophages and Metabolite Signaling in Metabolic Disease"
10:05 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 10:55 am	"Mitochondria Functional Genomics: Genes, Proteins and Alternative Nutrients"
10:55 am - 11:00 am	Discussion
11:00 am - 11:10 am	"Quantifying Mitochondrial Ultrastructure in Cryo-Electron Tomography Using a Surface Morphometrics Pipeline"
11:10 am - 11:15 am	Discussion
11:15 am - 11:35 am	"Leveraging Biogenic Small Molecule Screens Towards the Treatment of Mitochondrial Disease in Primary Muscle Systems"
11:35 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Plasticity of Mitochondrial ATP Synthase in Health and Disease"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Functional Characterization of Mitochondrial Derived Vesicles (MDVs) From Rat Liver"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Challenge of the Paradigm on ROS at High Mitochondrial Membrane Potential: Hydrogen Peroxide Production is Independent of Membrane Potential and Q Redox State Under Tissue Normoxia"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Mitochondrial Carrier Proteins and Transporters Discussion Leader:
6:00 pm - 6:15 pm	Introduction by Discussion Leader
6:15 pm - 6:35 pm	"Charge Movements During Adenine Nucleotide Exchange by the Mitochondrial ADP/ATP Carrier"
6:35 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	"Hem25p is a Mitochondrial Isoprene Transporter"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Metabolism, Cellular Decisions and the Language That Unites Them"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"Mitochondrial Apoptosis Mediated Through VDAC2 and Bak is Upregulated in Hepatocarcinoma, Providing an Achilles Heel for Therapy"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Mitochondria in Senescence and Aging Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"DNA Damage and Mitochondrial Dysfunction in Aging and Neurodegeneration"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Nucleic Acid-Mediated Mitonuclear Signaling"
10:05 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 10:55 am	"Mitochondrial Dynamics and the Senescence-Associated Secretory Phenotype"
10:55 am - 11:00 am	Discussion
11:00 am - 11:10 am	"The Unique Bioenergetic Fingerprint of Synaptic Mitochondria"
11:10 am - 11:15 am	Discussion
11:15 am - 11:35 am	"The Phosphatase-Dependent Control of Mitochondrial Mass"
11:35 am - 11:45 am	Discussion
11:45 am - 11:55 am	"The Pyruvate Dehydrogenase Complex Regulates Mitochondrial Matrix Protein Phosphorylation and Mitophagic Selectivity, Independent of its Catalytic Activity"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Mitochondrial Augmentation of Hematopoietic Stem Cells: New Learnings Based on Single Cell Analysis"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Iron Trafficking and Metabolism Discussion Leader:
6:00 pm - 6:15 pm	Introduction by Discussion Leader
6:15 pm - 6:35 pm	"Frataxin Depletion Leads to Decreased Soma Size and Activation of AMPK Metabolic Pathway in Dorsal Root Ganglia Sensory Neurons"
6:35 pm - 6:45 pm	Discussion
6:45 pm - 7:05 pm	"Mitochondrial Remodeling In Response to Nutrient Stress"
7:05 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"Mitochondrial Microproteins Link Metabolic Cues to Respiratory Chain Biogenesis"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"Persister Act: Translating Cell Death Signaling Into Survival"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Gyorgy Hajnoczky & Orian Shirihai

Mitochondria Emotion Inc

Research reported in this publication was supported by the National Institute On Aging, National Institute Of Environmental Health Sciences, National Institute Of Neurological Disorders And Stroke, and the National Cancer Institute of the National Institutes of Health under Award Number R13AG071053. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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