Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Mitochondrial Response to Stress in Different Cellular Contexts
Discussion Leader: Johannes Herrmann (University of Kaiserslautern, Germany)
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:15 pm
Aleksandra Trifunovic (University of Cologne, Germany)
"Mitochondrial Stress Response Dictates Tissue Remodeling"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Konstanze Winklhofer (Institute for Biochemistry and Pathobiochemistry, Ruhr-University Bochum, Germany)
"Mitochondrial Signaling Platforms: A Link Between Innate Immunity and Neurodegeneration"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Patrick Chinnery (University of Cambridge, United Kingdom)
"Molecular Basis of Tissue and Organ Vulnerability to Mitochondrial Insults"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mitochondria at the Heart of the Matter
Discussion Leader: Luca Scorrano (University of Padua, Italy)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Julio Ferreira (University of Sao Paulo, Brazil)
"Mitochondria at The Heart of miRNA Processing"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Alex Chia Yu Chang (Shanghai Jiao Tong University School of Medicine, China)
"Telomere-Mitochondria Homeostasis in the Heart"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Anna Zoccarato (King's College London, United Kingdom)
"Intermediary Metabolism and Redox State in Pathological Cardiac Remodeling"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
John Elrod (Temple University, United States)
"Novel Calcium Regulatory Mechanisms Governing Cellular Metabolism"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Ambre Bertholet (UCLA, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mitochondria in Environmental Health
Discussion Leader: Laurie Sanders (Duke University, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Joel Meyer (Duke University, United States)
"Neurotoxicity of Mitotoxic Stressors Varies Depending on Mechanism of Toxicity"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Phillip West (The Jackson Laboratory, United States)
"Mitochondria-Driven Inflammation in Neurotoxicant Exposure"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
(Un)conventional Mitochondrial Signaling
Discussion Leader: Jose Antonio Enriquez (Centro Nacional de Investigaciones Cardiovasculares Carlos III, Spain)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Kivanc Birsoy (The Rockefeller University, United States)
"Understanding the Role of Mitochondrial Glutathione Homeostasis in Physiology and Pathophysiology"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Lena Ho (Duke-NUS Medical School, Singapore)
"Mitochondrial Microproteins: Unconventional Players in Metabolic Regulation"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Andres Norambuena (University of Virginia, United States)
"A Novel Lysosome-to-Mitochondria Signaling Pathway in The Brain"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
María Mittelbrunn (Molecular Biology Center “Severo Ochoa”, CSIC, Spain)
"Immunometabolism at the Crossroad Between Inflammation and Aging"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Maintaining Mitochondrial DNA Integrity and Function
Discussion Leader: Maria Eugenia Soriano (University of Padova, Italy)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Laurie Sanders (Duke University, United States)
"Mitochondrial DNA Repair Defects in the Brain"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Naotada Ishihara (Graduate School of Science, Osaka University, Japan)
"Dynamic Regulation of Mitochondrial Membranes and Genomes"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Carolyn Suzuki (Rutgers- New Jersey Medical School, United States)
"Regulating Mitochondrial DNA and RNA Dynamics by TFAM Acetylation and Phosphorylation"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lost in (Mitochondrial) Translation
Discussion Leader: Carlos Moraes (University of Miami, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Antoni Barrientos (Miller School of Medicine, University of Miami, United States)
"Mechanisms of Mitochondrial mRNA-Programmed Translation Regulation"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Hana Antonicka (McGill University, Canada)
"Mitochondrial RNA Processing: to Cut or Not to Cut?"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Joanna Rorbach (Karolinska Institute, Sweden)
"Unique Features of Mammalian Mitochondrial Translation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Peter Rehling (University Medical Center Gottingen, Germany)
"Regulating Mitochondrial Translation"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mitochondria and AI: What We Can Learn From New Computational Approaches
Discussion Leader: Jared Rutter (University of Utah, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Fabiana Perocchi (HMGU, Germany)
"In silico Identification of Mitochondrial Cell Type Specific Markers"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Gyorgy Hajnoczky (Thomas Jefferson University, United States)
"Enabling the Structural Analysis of Mitochondria and Their Interactions by AI"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Aleksandra Filipovska (University of Western Australia, Australia)
"Quantitative Subcellular Reconstruction and Volumetric Analyses of Inter-Organelle Networks"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Unresolved Questions in Mitochondrial Biology
Discussion Leader: Aleksandra Trifunovic (University of Cologne, Germany)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Cristina Ugalde (Center for Biological Research (CIB-CSIC), Spain)
"Structural and Functional Heterogeneity of the Mammalian Respiratory Chain"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Nils-Goran Larsson (Karolinska Institutet, Sweden)
"The Molecular Basis for Tissue-Specific Differences in Mitochondrial Function"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Johannes Herrmann (University of Kaiserslautern, Germany)
"How Mitochondrial Proteins Shape The Extramitochondrial Proteome: A Novel Concept of Aging?"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Alessandra Boletta (San Raffaele Scientific Institute, Italy)
"Mitochondrial Dysfunction in the Kidney – What do Cilia Have to Do With it?"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Jose Antonio Enriquez (Centro Nacional de Investigaciones Cardiovasculares Carlos III, Spain)
"Functional Effects of Mitochondrial Heteroplasmy"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Practical Applications of Mitochondrial Biology
Discussion Leader: Rita Horvath (University of Cambridge, United Kingdom)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
David Lynch (Children's Hospital of Philadelphia, United States)
"Loss of Frataxin: How to Address Its Effects on Mitochondrial Function"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Mary Herbert (Monash University, Australia)
"MtDNA Mutations: Breaking the Cycle of Transmission"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Valerio Carelli (University of Bologna, IRCCS Institute of Neurological Sciences of Bologna, Program in Neurogenetics, Italy)
"Modeling Mitochondrial Dysfunction in Brain Organoids"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure