| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Structure and Mechanism of Membrane Transport Proteins |
| Peter Pedersen, Chair
"Membrane transporters: New life in a mature field" |
| Douglas Rees
"Structural studies of the BtuCD vitamin B12 transporter" |
| Giuseppe Inesi
"Interconversion of Ca2+ binding and phosphorylation potentials in the Ca2+ transport ATPase: Relationships of structure and function" |
| Jeff Abramson
"Structure and mechanism of lac permease" |
| Joanne Lemieux
"Structure and mechanism of glycerol-3-phosphate transporter from E.coli" |
| Welcoming Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Photo |
| 9:00 am - 12:30 pm | Structure and Rotary Mechanism of F1Fo ATP Synthase |
| Richard Cross, Chair
"Introduction to the structure and rotary mechanism of the ATP
synthase" |
| John Walker
"How the F-ATPase makes ATP" |
| Masasuke Yoshida
"Single molecule enzymology of ATP synthase" |
| Alan Senior
"Quantitative assays of stator subunit interactions" |
| Stanley Dunn
"Hypothesis on the function of the epsilon subunit of ATP synthase" |
| Wolfgang Junge
"On the efficiency of rotary F-ATPase" |
| Robert Nakamoto
"Kinetics of rotational catalysis" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Mechanism of Ion Translocation Through Fo |
| Brian Cain, Chair
"Abusing Fo with mutagenesis" |
| Steven Vik
"The role of subunit a in proton translocation" |
| Robert Fillingame
"Coupling proton transport to c-ring rotation via helical swiveling
at the a-c interface" |
| Peter Dimroth
"Ion translocation via rotor and stator channels of Fo in relationship to torque generation"
|
| Terry Krulwich
"A specially adapted Fo is required for oxidative phosphorylation at high pH" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Structure, Function and Regulation of the V-ATPases |
| Barry Bowman, Chair
"Structure of the V-ATPase and its role in the cell" |
| Stephan Wilkens
"Structural features of the vacuolar ATPase from bovine and yeast by electron microscopy" |
| Patricia Kane
"Regulation of the yeast vacuolar H+-ATPase" |
| Masamitsu Futai
"V-ATPase: rotational catalysis and diverse isoforms" |
| L. Shannon Holliday
"Molecular, biochemical and physiological studies of the interaction
between V-ATPase and microfilaments." |
| Vladimir Marshansky
"Is the V-ATPase a pH-sensing protein? The a2-subunit localizes
in kidney endosomes and interacts with the Arf6 GEF, ARNO" |
| Andreas Mayer
"A role for Vo in vacuolar membrane fusion". |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Assembly and Targeting of Bioenergetic Complexes |
| Sharon Ackerman, Chair
"Overview of assembly, targeting and regulation of bioenergetic complexes" |
| Tom Stevens
"Assembly and targeting of the yeast vacuolar ATPase" |
| Dennis Brown
"The V-ATPase: novel protein interactions and recycling mechanisms in proton-secreting epithelial cells" |
| Svetlana Lutsenko
"Human copper-transporting ATPase ATP7B: functional properties and regulation" |
| Antoni Barrientos
"Towards the role of cytochrome c in COX assembly" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Workshops |
| ATPase Workshop
Stanley Dunn, Emma Jean Bowman, Co-Chairs |
| |
| Respiratory Complex Workshop
Antony Crofts, Thorsten Friedrich, Co-Chairs |
| |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Structure and Mechanism of Cytochrome c Oxidase |
| Robert Gennis, Chair
"An introduction to cytochrome c oxidase" |
| Peter Brzezinski
"Redox-coupled proton translocation by cytochrome oxidase" |
| Shelagh Ferguson-Miller
"Water and proton exit from cytochrome c oxidase: evidence for defined pathways" |
| Olof Einarsdottir
"The reduction of dioxygen to water: Sequential or branched mechanism?" |
| Michael Verkhovsky
"Proton translocation steps in the catalytic cycle of cytochrome c oxidase" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Structure and Mechanism of Cytochrome bc1 and Other Respiratory Complexes |
| Bernard Trumpower, Chair
"What we know and what we don't know about the structure and mechanism of the cytochrome bc1 complex" |
| Carola Hunte
"Structural analysis of the molecular mechanism of the cytochrome bc1 complex" |
| William Cramer
"Crystallization and structure of a defined protein-detergent-lipid complex of the cytochrome b6f complex of oxygenic photosynthesis" |
| Ed Berry
"New insights from the structures of mitochondrial complex III at 2.1 Å and complex II at 3.5 Å" |
| Gary Cecchini
"Molecular architecture of succinate dehydrogenase (complex II) prevents reactive oxygen species generation" |
| Ulrich Brandt
"Insights into the mechanism of mitochondrial complex I from Yarrowia
lipolytica from site-directed mutants and structural analysis." |
| Hiroshi Kadokura
"Protein disulfide bond formation: mechanisms of electron transfer from periplasmic substrates to quinone via DsbA and DsbB" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Mitochondrial Import and Bacterial Transport (II) |
| Barry Rosen, Chair
"How an iron-sulfur protein was
recruited as the catalytic subunit of a bacterial ion pump" |
| Walter Neupert
"Biogenesis of mitochondria" |
| Roland Lill
"Biogenesis of iron-sulfur proteins in mitochondria: Components, mechanisms and pathogenesis" |
| Akihito Yamaguchi
"Crystal structure of multidrug efflux transporter AcrB and its functional implications" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
