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Molecular and Cellular Biology of Lipids

Gordon Research Conference

Re-Envisioning the Fluid Mosaic Model of Membrane-Lipid Interactions with Next-Generation Technologies

July 27 - August 1, 2025

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GRC Education Requirements: Undergraduates or those who have not obtained a bachelor's degree in science/engineering (or acceptable equivalent) are not eligible to apply to attend Gordon Research Conferences or Seminars.

Chair

Vice Chair

Waterville Valley

56 Packard's Road

Waterville Valley, New Hampshire, United States

Venue and Travel Information

Application Information

Applications for this meeting must be submitted by June 29, 2025. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the conference chair if more seats become available due to cancellations.

Conference Description

The Molecular and Cellular Biology of Lipids GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The 2025 MCBL Gordon Conference will place a particular focus on re-envisioning the fluid mosaic model of membrane-lipid nteractions with next-generation technologies. The fluid mosaic model revolutionized our understanding of membrane-lipid interactions when it was proposed about 50 years ago. While the fundamental structure proposed by this model remains valid, re-envisioning the model in light of the wealth of knowledge made possible by new analytical tools is essential to advance our understanding of the role of membrane lipids in cellular function. The 2025 MCBL will incorporate and build on the major successful strategies of previous meetings to explore this unique focus.

Related Meeting

This GRC will be held in conjunction with the "Molecular and Cellular Biology of Lipids" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Re-Envisioning the Fluid Mosaic Model Discussion Leader:
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:15 pm	"Are Cell Membrane Lipid Bilayers Finely-Tuned Molecular Assemblies?"
8:15 pm - 8:25 pm	Discussion
8:25 pm - 9:05 pm	"Lipid Metabolism and Signaling Across Time and Space"
9:05 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Sensors and Analyses of Lipid Diversity and Dynamics Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"From Minimal Cells to an RNA-Lipid World"
9:35 am - 9:45 am	Discussion
9:45 am - 10:10 am	"Molecular Tools for Precision Imaging of Membranes"
10:10 am - 10:20 am	Discussion
10:20 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	"Imaging Lipids: Transport and Ultrastructural Organization"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am	Discussion
11:45 am - 12:10 pm	Late-Breaking Topic
12:10 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Organelle Lipid Homeostasis Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:05 pm	"The Role of Lipids in Nuclear Pore Complex Architecture and Function"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	"Lipid Flippases: Atypical Substrates and Physiological Functions"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:15 pm	"Regulation of Coatomer II-Mediated ER-to-Golgi Trafficking of Sphingolipids"
9:15 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Spatial Compartmentalization and Trafficking of Lipids Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"Dissecting Lipid Dynamics at ER-Vacuole Contact Sites: From Molecular Players to Functional Outcomes"
9:35 am - 9:45 am	Discussion
9:45 am - 10:10 am	"Control of Intracellular Cholesterol Distribution via Non-Vesicular Lipid Transport at Membrane Contact Sites"
10:10 am - 10:20 am	Discussion
10:20 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	"The Mitochondrion: A Membrane-Building Powerhouse"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am	Discussion
11:45 am - 12:10 pm	"The BARS-CtBP Minimal Fission Machinery Involved in Intracellular Membrane Traffic Relies on the Lysophosphatidic Acid - Phosphatidic Acid Conversion Reaction"
12:10 pm - 12:20 pm	Discussion
12:20 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cholesterol: Synthesis, Signaling, and Transport Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:05 pm	"Cellular Signaling by Cholesterol"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	"Membrane Protein Regulation by Cholesterol Metabolites"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:15 pm	"Intracellular Cholesterol Trafficking in Niemann-Pick C Disease"
9:15 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Regulation of Lipid Synthesis Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"Ceramide Metabolism and Function at the Plasma Membrane"
9:35 am - 9:45 am	Discussion
9:45 am - 10:10 am	"Acyl Chain Remodeling of Mitochondrial Cardiolipin: Mechanism and Function"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:00 am	Short Talk Selected from Poster Abstracts
11:00 am - 11:05 am	Discussion
11:05 am - 11:30 am	"Insights into the Fat-Regulating Phosphatidic Acid Phosphatase and its Potential Role as a Therapeutic Target"
11:30 am - 11:40 am	Discussion
11:40 am - 12:05 pm	"Membrane Lipid Biosynthesis in Archaea"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Molecular Dynamics Simulations to Visualize Lipid Interactions Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:05 pm	"Computers and Membranes: Using Molecular Dynamics Simulations to Understand the Effect of Lipids on Mechanosensitive Channels Function"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	"Molecular Mechanisms of MFSD2A-Mediated Fatty Acid Transport"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:15 pm	Late-Breaking Topic
9:15 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Lipid Oxidation and Infection Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"Redox Lipidomics of Regulated Cell Death Programs: "Human Science Fragments Everything in Order to Understand it, Kills Everything in Order to Examine it." Leo Tolstoy, War and Piece, 1869"
9:35 am - 9:45 am	Discussion
9:45 am - 10:10 am	"Phosphatidylcholine Synthesis Protects Germ Cells from Ferroptosis in C. Elegans"
10:10 am - 10:20 am	Discussion
10:20 am - 10:30 am	Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:30 am	"Infections and Lipid Remodeling: A Tug-of-War for Survival"
11:30 am - 11:40 am	Discussion
11:40 am - 12:05 pm	Late-Breaking Topic
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Lipids in Inflammation and Disease Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:05 pm	"Uncovering the Function and Regulation of Plasma Lipids in Cardiovascular Disease"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm	Discussion
8:30 pm - 9:10 pm	"Lipid Mediators and Cellular Mechanisms in the Resolution of Inflammation"
9:10 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	Closing Remarks
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Conference Links

Conference History Molecular and Cellular Biology of Lipids (GRS) Contribute Financially to This Conference

Conference Fees

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Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

Preparing your GRC poster

Funding Opportunities

Financial assistance is available beginning in 2026 for qualified applicants through the Carl Storm Opportunity Fellowships program. Learn more.

Registration Fees

Conferee Single Room:

$1,680.00

Conferee Shared Room:

$1,490.00

Conferee Off-Site:

$1,065.00

Guest Single Room:

$1,490.00

Guest Shared Room:

$1,300.00

Guest Off-Site:

$875.00

Child 4-12 yrs Shared Room:

$650.00

Child 4-12 yrs Off-Site:

$438.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Bus Arriving:

$62.00

Bus Departing:

$62.00

Additional Fee Info

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