| Sunday July 1, 2001 |
| Evening | I. Keynote Addresses |
| Elaine Fuchs (University of Chicago, IL)
Balancing Proliferation, Differentiation and Development in Skin |
| Monday July 2, 2001 |
| Morning | II. Signal Transduction I |
| *Tony Pawson (Samuel Lunenfeld Institute, Mt Sinai Hospital,
Canada)
Receptors and adaptors in cytoskeletal control |
| Lew Cantley (Beth Israel-Deaconess Medical Center, MA)
Signaling via PI 3-kinase |
| Dafna Bar-Sagi (State University of New York, NY)
Positive and
negative regulation of RTK-Ras signaling |
| Natalie Ahn (University of Colorado)
Proteomic analysis of signaling pathways |
| Evening | III. Signal Transduction II |
| *Nick Tonks (Cold Spring Harbor Laboratory, NY) |
| Jack Dixon (Univ. Michigan, MI)
Phosphoryl transfer: a key element
of signal transduction |
| Doug Hilton (Walter and Eliza Hall Institute for Medical Research,
Australia)
SOCS proteins - negative regulators of cytokine signaling |
| Mike Dustin (New York University School of Medicine, New York, NY)
The immunological synapse and sustained T cell signaling |
| Tuesday July 3, 2001 |
| Morning | IV. Transcription |
| *Carol Prives (Columbia University, New York) |
| Doug Dean (Washington University School of Medicine, MO)
Rb and cell cycle control |
| Michael Karin (Univ. of California, San Diego and HHMI, CA)
NF-kB, AP-1 and the Control of Cell Proliferation |
| Erin O'Shea (Univ. of California, San Francisco Medical School and
HHMI, CA)
Quantitative studies of signal transduction |
| Evening | V. Development |
| *Cynthia Kenyon (Univ. of California, San Francisco Medical School, CA)
Endocrine regulation of lifespan in the nematode C. elegans |
| Nancy Hopkins (MIT, Cambridge, MA)
Insertional mutagenesis
identifies genes required for growth and development in zebrafish |
| Morris Birnbaum (University of Pennsylvania)
Akt/PKB as regulator
of growth and metabolism |
| Wednesday July 4, 2001 |
| Morning | VI. Cell Cycle/Checkpoints |
| *Angelica Amon (Massachusetts Institute of Technology, MA)
Exit from mitosis in budding yeast |
| Greg Hannon (Cold Spring Harbor Laboratory, NY)
Transformation of
normal human cells by E1a |
| Lea Harrington (Samuel Lunenfeld Institute, Mt Sinai Hospital,
Canada)
Telomeres, telomerase, and cell proliferation |
| Mike Tyers (Amgen Institue, Canada)
Multi-site phosphorylation of a
CDK inhibitor sets a threshold for S-phase onset |
| Evening | VII. Checkpoints/Cancer |
| *Jackie Lees (MIT, Cambridge, MA)
The role of the E2F transcription
factors in proliferation contro |
| Ron DePinho (Dana Farber Cancer Institute, MA)
Mechanisms of
cellular senescence and crisis in mice and humans |
| Alan D'Andrea (Dana Farber Cancer Institute, MA)
Convergence of the ATM and Fanconi anemia signaling pathways |
| Thomas Jenuwein (IMP, Vienna, Austria)
Histone Methylation and chromosome stability during mouse development |
| Thursday July 5, 2001 |
| Morning | VIII. Extracellular Matrix |
| *Benny Geiger (Weizmann Institute, Israel)
Mechanochemical
regulation of focal adhesion assembly and signaling |
| Rick Assoian (Univ. of Pennsylvania,PA)
Growth factors, the ECM, ERK and cyclin D1: trying to fit the pieces together |
| David Schlaepfler (Scripps Institute, CA)
Role of FAK in promoting integrin and growth factor-stimulated cell motility |
| Frank Gertler (Massachusetts Institute of Technology, MA)
Regulation
of cell motility by Ena/VSP proteins |
| Evening | IX. Programmed Cell Death |
| *Craig Thompson (University of Pennsylvania, PA)
Why do mitochondria play a central role in cell survival and proliferation |
| Sally Kornbluth (Duke Univerity School of Medicine, NC)
Reconstitution of apoptosis in a cell free system |
| Josef Penninger (Amgen Institute, Canada)
AIF-identification of a potential second, mitochondrially regulated cell death pathway |
| Gerard Evan (University of California-San Francisco, CA)
Myc Induced
Oncogenesis; The Roles of Proliferation and Angiogenesis |
| Linda Penn (Ontario Cancer Institute, Canada)
Mechanism of Myc-induced apoptosis |
| *indicates Session Chair |
