| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Speaker |
| Discussion Leader: Jacqueline Lees (MIT, Center for Cancer Research) |
| John Diffley
"DNA Replication, Genome Stability and Cancer: Lessons from Budding Yeast?" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell Cycle/Checkpoints |
| Discussion Leader: Mike Tyers (Samuel Lunenfeld Institute, Toronto) |
| 9:00 am - 9:40 am | Mike Tyers (Samuel Lunenfeld Institute, Toronto)
"Critical Cell Size, Ribosome Biogenesis and Commitment to Division" |
| 9:40 am - 10:10 am | David Shore (University of Geneva, Switzerland)
"A regulatory switch for growth control of ribosomal protein gene transcription in yeast?" |
| 10:10 am - 10:45 am | Coffee Break / Photo |
| 10:45 am - 11:15 am | James Degregori (University of Colorado Health Sciences Center, CO)
"Blood and Competition: the loss of E2F2 Promotes Leukemiagenesis by Inhibiting Cell Cycle Progression" |
| 11:15 am - 11:50 am | Dan Durocher (Samuel Lunenfeld Institute, Toronto)
"RFC(Elg1) is a Novel Alternative RFC Complex Required to Maintain Genome Stability" |
| 11:50 am - 12:30 pm | Jim Ferrell (Stanford U., CA) |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Signaling I |
| Discussion Leader: Dafna Bar-Sagi (SUNY, Stony Brook, NY) |
| 7:30 pm - 8:00 pm | Dafna Bar-Sagi (SUNY, Stony Brook, NY)
"Ras Signaling and Growth Control" |
| 8:00 pm - 8:30 pm | Jeff Wrana (U. Toronto, Canada)
"TGFbeta Signaling and Cancer Progression" |
| 8:30 pm - 9:00 pm | Mike Dustin (NYU School of Medicine, NY)
"Regulation of Immunological Synapse Function and Assembly Through Proteolysis" |
| 9:00 pm - 9:30 pm | Tyler Jacks (MIT, Center for Cancer Research, MA)
"K-ras-Induced Mouse Tumor Models" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Chromosome Replication/Dynamics |
| Discussion Leader: Titia de Lange (Rockefeller, NY) |
| 9:00 am - 9:35 am | Steve Bell (MIT, MA)
"Mapping and Controlling Eukaryotic Origins of Replication" |
| 9:35 am - 10:10 am | Lea Harrington (Ontario Cancer Institute/Amgen Research Institute, Toronto)
"Making the Most of a Little: Mammalian Telomerase and Telomere Recruitment" |
| 10:10 am - 10:30 am | Coffee Break |
| 10:30 am - 11:10 am | Doug Koshland (Carnegie Institute, MD)
"Chromosome Packaging and Genome Integrity" |
| 11:10 am - 11:50 am | Vicki Lundblad (Baylor College of Medicine, TX)
"Replication and Resection: Regulating Access to the Telomere" |
| 11:50 am - 12:30 pm | Titia de Lange (Rockefeller, NY)
"Protection of Human Chromosome Ends" |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Signaling II |
| Discussion Leader: Ben Neel (Beth Israel-Deaconess Medical Center, MA) |
| 7:30 pm - 8:00 pm | Joan Ruderman (Harvard Medical School, MA)
"PKA and the G2/M Transition" |
| 8:00 pm - 8:30 pm | Mike Yaffe (MIT, Center for Cancer Research, MA)
"The Role of PhosphoSerine/Threonine-Binding Domains in Mitotic Regulation" |
| 8:30 pm - 9:00 pm | Ilaria Rebay (Whitehead Institute, MA)
"Signal Integration during Retinal Development" |
| 9:00 pm - 9:30 pm | Ben Neel (Beth Israel-Deaconess Medical Center, MA)
"Tyrosine Phosphatases and their Binding Proteins in Cancer" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DNA Damage/Checkpoints |
| Discussion Leader: Steve Elledge (Baylor College of Medicine, TX) |
| 9:00 am - 9:40 am | Orna Cohen-Fix (NIH, MD)
"Stopping and Restarting the Cell Cycle in Response to DNA Damage" |
| 9:40 am - 10:20 am | Steve Elledge (Baylor College of Medicine, TX)
"Sensing and Responding to DNA Damage" |
| 10:20 am - 10:45 am | Coffee Break |
| 10:45 am - 11:25 am | Steve Jackson (Cambridge, UK)
"Early Events in the DNA Damage Response" |
| 11:25 am - 12:05 pm | Alan D'Andrea (Harvard Medical School, MA)
"The Fanconi Anemia/BRCA Pathway" |
| 12:05 pm - 12:25 pm | Short Talk |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Gene Regulation |
| Discussion Leader: Bev Emerson (Salk Institute for Biological Studies, CA) |
| 7:30 pm - 8:00 pm | Bev Emerson (Salk Institute for Biological Studies, CA)
"Transcriptional Regulation by p53 through Chromatin" |
| 8:00 pm - 8:30 pm | Ali Shilatifard (Saint Louis University School of Medicine, MI)
"COMPASS and GPS, tools in defining the role of histone modifications in regulation of gene expression" |
| 8:30 pm - 9:00 pm | Dan Gottschling (Fred. Hutchinson Cancer Center, WA)
"Genomic Instability in Old Yeast Cells: A Model for the Link Between Cancer and Age" |
| 9:00 pm - 9:30 pm | Bill Tansey (CSHL, NY)
"Transcriptional Control and the Ubiquitin-Proteasome System" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cancer |
| Discussion Leader: Gerard Evan (UCSF, CA) |
| 9:00 am - 9:40 am | Tak Mak (Adv Med Discovery Institute, University Health Network, Toronto)
"Genetic Analysis of Cell Survival Pathways" |
| 9:40 am - 10:20 am | Tom Look (Harvard Medical School, MA)
"The New Genetics of T-cell Leukemia: a Fish Tale" |
| 10:20 am - 10:40 am | Coffee Break |
| 10:40 am - 11:00 am | Suzanne Brady (Washington University School of Medicine, MO)
"p19ARF and NPM/B23: Opposing Forces in the Nucleolus" |
| 11:00 am - 11:40 am | Andi McClatchey, (MGH, MA)
"Function of the NF2 Tumor Suppressor, Merlin, in Tumorigenesis and Metastasis" |
| 11:40 am - 12:20 pm | Gerard Evan (UCSF, CA)
"The Relative Roles of Cell Proliferation and Apoptosis in Cancer Development" |
| 12:20 pm | Business Meeting |
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Genomics/Proteomics/Modeling |
| Discussion Leader: Rick Young (Whitehead Institute, MA) |
| 7:30 pm - 8:00 pm | Rick Young (Whitehead Institute, MA) |
| 8:00 pm - 8:30 pm | Marc Vidal (Dana Farber Cancer Center, MA)
"Protein Networks and Development" |
| 8:30 pm - 9:00 pm | Matthias Mann (Denmark)
"Mass Spectrometry Based Tools for Determining Signaling Dependent Protein-protein Interactions" |
| 9:00 pm - 9:30 pm | Karim Labib (Paterson Institute for Cancer Research, UK)
"Functional Proteomics by Induced Proteolysis in vivo" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
