Dynamic One-Carbon Use on a Changing Planet

The microbial metabolism of one-carbon (C1) compounds is important in marine and terrestrial environments. C1-based processes include conversions of methane, carbon dioxide, methanol, formic acid, and carbon monoxide; C1 organic compounds such as methylated amines, dimethyl sulfide, and methyl phosphonates; and metabolic intermediates including corrinoid and tetrahydrofolate derivatives and formaldehyde. Transformations of C1 compounds play a key role in the biogeochemical cycling of carbon and associated elements in the biosphere. Some of these compounds represent important energy sources in natural and industrial processes, and, as greenhouse gases, are important in environmental change and climate. Microbial C1 metabolism is thought to be an ancient process on Earth and is considered a promising energy source that could fuel life on other planetary bodies. The 2018 C1 Gordon Research Conference will highlight the most recent research on all aspects of microbial one-carbon metabolism, including natural and synthetic systems and at scales spanning molecules, enzymes, cells, and ecosystems. Complementary cross-disciplinary perspectives on C1 metabolism from microbiology, biochemistry, molecular biology, structural biology, evolution, microbial ecology, and systems and synthetic biology will be provided. Innovative applications of C1 metabolism in industrial processes and remediation will be presented.

As in previous editions of this long-running meeting, the 2018 conference, with its associated GRS, will bring together early career and senior researchers and academics from the research C1 community. Investigators new to the field are encouraged to apply. The GRC format, with extensive discussions, interactive poster sessions, and informal gatherings in the afternoons and evenings, will provide an ideal setting for investigators from different fields and generations, to exchange ideas, brainstorm, and discuss opportunities for collaboration.