Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Membrane Research and its Impact on Medicine
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"Linking the ER Stress-Sensing Machinery to Peroxisomal Lipid Import"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"Molecular Basis of Inherited Parkinson's Disease"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Atomistic Insights into Signal Integration at the Lysosome Membrane"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Targeting to Organelles and Quality Control
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"Protein Import into Peroxisomes"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Protein Import into Chloroplasts: the Ancestor and the Signal"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Exploration of a Translocation Process in the Secretion of Leaderless Cargoes"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Translocon Remodeling During Protein Synthesis at the ER"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"When Protein Folding and Assembly Fails: Membrane Protein Quality Control at the ER"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Import Mechanism of Peroxisomal Proteins with an N-Terminal Signal Sequence"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Tankyrase-Mediated PARylation of PEX Proteins Impairs Peroxisome Import"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Exploring the Function of the SRP-Independent (SND) Proteins in Membrane Protein Biogenesis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Poster Previews
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Organelle Communication and Coordination
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"Mitochondrial Functional Flexibility"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"From Muscle to Memory: ER and Long-Distance Calcium Signaling in Neurons"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Molecular Insights into Lysosomal Biogenesis and Stress Response"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Mechanistic Insights into Bulk Lipid Delivery from the Cryo-EM Structure of a Bridge-Like Lipid Transfer Protein Complexed with a Scramblase"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"How a Bridge-Like Lipid Transport Protein Controls Plasma Membrane Fluidity and Breast Cancer Aggressiveness"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Breaking the Technological Limits in Membrane Research
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"The Architecture of Membrane Contact Sites"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Mechanistic Characterization of Membrane Property Sensors"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Massively Paralleled Genome-Wide Optical Pooled Screen of Secretory Organelles and Cargo Receptors"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Towards Reconstituting Transmembrane Communication of Protein Assemblies: A Suspended Planar Membrane System"
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
"New Enzymes in Hydroxy-Lipid Catabolism"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Cryogenic FIB-SEM for Whole-Cell Membrane Biology Discovery"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Deciphering the Logic of Mammalian Mitochondrially-Localized Translation Through Optogenetically-Controlled Proximity-Specific Ribosome Profiling"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Poster Previews
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"Mechanism of Lipid Droplet Organelle Biogenesis from the Endoplasmatic Reticulum"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"Cellular Mechanisms of Lipid Storage and Lipotoxicity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Keep Calmin and Carry on: Examining the ER in Cell Migration"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Crossing the Ts in Lipid Control: From TMEM to Torsin"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Spatial Organization of Lipid Droplet Catabolism in Yeast"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Vesicular Trafficking and Secretion
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"Sec24 Intrinsically Disordered Domain Tunes COPII Vesicle Morphology"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Structural Biology of Trafficking GTPase Regulators"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Exocyst Functions to Control Exocytic SNARE Complex Assembly and Vesicle Fusion"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
"Roles of the Small GTPase Arf1 in Compartmentalization and Trafficking"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Two Opposing Membrane Domains Mediate the Fusion of Large Secretory Vesicles"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
"The Mechanism of ESCRT-Mediated Membrane Fission Revealed by Archeal Proteins"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Poster Previews
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"How the CO2 -Fixing Pyrenoid gets its Membranes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
"Revealing Mechanisms of Lipid Homeostasis Using Membrane Editing and Proximity Proteomics"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"The Regulated Architecture of the Membrane of an Animal Cell: An ATP Fueled Fabric"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Alterations in Lipid Saturation Trigger Remodeling of the Outer Mitochondrial Membrane"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"ER Fusogens Maintain Membrane Reservoir to Ensure Brain Function"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Organelle Division, Inheritance and Shaping
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
"The Convolutated Nature of Interorganelle Lipid Fluxes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Architecture of Synapses Revealed by Cryo-Electron Tomography"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Receptor Endocytosis in the Axon Initial Segment Maintains Neuronal Polarity"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"The Quality Control Mechanism of Lipid Droplet Biogenesis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"The Mechanism of SMAD Inactivation at the Nuclear Envelope"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
"Regulation of Axonal Trafficking by ER-SV and DCV Membrane Contact Sites in Developing Neurons"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Specializations of the Neuronal ER and Intercellular Communication"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Organellar Contact Sites in Axons as Hubs of Mitophagy"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"A Phosphoinositide, a Pentamer and a Prediction: How Yeast Provide Insights into a Neurodegenerative Disease"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane Turnover and Repair
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"Stress, Rupture and Repair: Cellular Responses to Endolysosomal Damage"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"Mechanisms of Cargo Selection and Autophagosome Biogenesis in Selective Autophagy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Bending but not Breaking: Mechanisms of Lysosome Resilience Under Pressure"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Golgi-Related Ubiquitylation Induced by the STING Pathway"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"Ultrastructural Visualization of Macroautophagy"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure