Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Understanding Ligand Intrinsic Efficacy
7:40 pm - 8:30 pm
"Beta-Arrestin-Coupled Receptors and G Protein-Coupled Receptors: A tale of Two Transducers"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"The Molecular Logic of Metabotropic Glutamate Receptor Heteromers"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Allostery, Bias and Efficacy: Three Sides of the Same Coin"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Functional Dynamics and Single-Molecule Visualization of Signaling
9:00 am - 9:20 am
"Single-Molecule Imaging Reveals the Dynamics and Activation of G Protein-Coupled Receptors"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"The Influence of Lipids on GPCR Conformational Dynamics"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"How Nanodomains of Quantised GPCR Intrinsic Activation Define Macroscopic Agonist Potency and Efficacy"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Modulation of G protein Dynamics by GPCR Ligands"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"Molecular Mechanisms of Metabotropic Glutamate Receptor/Arrestin Coupling"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Single Domain Antibodies and Allosteric Modulators for GPCRs: Discovery and Validation"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"The Alpha-helical Domain of Gα, a New Regulator of the Heterotrimeric G Protein Signaling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Ligand-Specific Activation Trajectories Dictate GPCR Signaling in Intact Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
AI-Driven GPCR Analysis and Drug Discovery
7:30 pm - 7:50 pm
"Structure-Based Design of GPCR Ligands Using Artificial Intelligence"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Drug Design with AI Structures: Separating Truth from Hallucination"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Deciphering Mechanisms of Allostery, Biased Agonism, G Protein Coupling Selectivity of GPCRs"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Interpretable AI for Uncovering Cooperativity and Allostery in Protein Complexes"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Closing the Generative AI Augmented GPCR Structure-Based Drug Discovery Loop"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Revolutionizing GPCR: Targeted Drug Discovery with Advanced Technologies
9:00 am - 9:20 am
"Precise Targeting of GPCR Signaling"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Non-Equilibrium Structural Pharmacology of the Mu-Opioid Receptor"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Uncovering the Action of Unconventional GPCR Stimuli"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"New Families of "Superdark" GPCR-like Proteins in Humans"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Activation of Relaxin Receptor Signaling by Diverse Agonists"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"An Engineered Optogenetic Platform to Activate Sub-Cellular GPCR Signalling"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"The Secret Life of G Proteins"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Discovery of Activating GPCR Antibodies with an AI-Enabled Platform"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bridging GPCR Signaling and Immune Regulation: Emerging Insights and Therapeutic Avenues
7:30 pm - 7:50 pm
"Modulation of Canonical and Atypical Chemokine Receptor Function by Nanobodies"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Exploiting the GPCR-Chemokine Network to Reprogram the Tumor Microenvironment for Improved Immunotherapy"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Spatial Regulation of GPCR-ERK Signaling"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Ramping Up Protein Complexes for Lymphatic Therapeutics"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"High Binding Plasticity and Ligand Promiscuity of the Atypical Chemokine Receptor ACKR5"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Central Role of GPCRs in Neuroscience and Neuropharmacology
9:00 am - 9:20 am
"Targeting G Protein Signaling Pathways to Disrupt the Maintenance of Chronic Pain"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Discovery of Novel GPCR Targeted Therapies for Neurological Disorders"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Brain Disorders and Muscarinics: Light at the End of the Tunnel"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Molecular Mechanisms of Inverse Agonism via K-Opioid Receptor–G Protein Complexes"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Neuropeptide Regulation of Mosquito Blood Feeding and Mating"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Interplay Between the Extracellular and Transmembrane Domains of a Holo-Adhesion GPCR"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Interactions Between the Opioid and PACAPergic Systems: Implications for Headache and Pain Management"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Structural and Dynamic Insights into Human κ-Opioid Receptor Signaling"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
GPCRs at the Heart of Metabolism: Unlocking New Avenues for Disease Intervention
7:30 pm - 8:10 pm
"GLP-1 Mechanisms in Diabetes, Obesity, Cardiovascular and Kidney Disease"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Metabolites as Signals in Adipose Tissue and Energy Homeostasis"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"GPCR Biased Signaling Strengthens Endothelial Cell Resilience"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Functional Implications of Biased Signaling at the GLP-1R"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Exploring GPCRs' Impact on Intracellular Signaling Landscapes
9:00 am - 9:20 am
"Subcellular Organization and Reorganization of GPCR Signaling"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"GPCR Signaling: A Spatial Story"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Monoamine Transporters: The Dynamic Modulators of Subcellular GPCR Activity"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Myosin VI Drives Arrestin-Independent Internalization and Signaling of GPCRs"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Signaling and Non-Signaling GPCRs in Type 2 Diabetes and Cardiac Regeneration"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"β-arrestin-Mediated Compartmentalization of Active GPCRs in Membrane Nanodomains via PIP2 Binding"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Regulated Anterograde Transport of Class A GPCRs Uncovered by a Genome-Wide CRISPR Screen and High Content Imaging"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Systematic Mapping of GPCR Signaling Networks: A Proteomic Approach to GRK- and ß-Arrestin-Dependent Interactions"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Expanding Horizons in GPCRs in Health and Disease
7:30 pm - 8:10 pm
"The Role of Protein Dynamics in GPCR Signaling"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Targeting Tumor-Suppressive Functions of Gs-Coupled GPCRs in Cancer"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Adhesion GPCRs Regulating Glucose and Energy Homeostasis"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Structural and Pharmacological Insights into Targeting Class B1 GPCRs for Metabolic Disease"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure