Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Understanding Ligand Intrinsic Efficacy
7:40 pm - 8:20 pm
"Beta-Arrestin-Coupled Receptors and G Protein-Coupled Receptors: A tale of Two Transducers"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"The Molecular Logic of Metabotropic Glutamate Receptor Heteromers"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Allostery, Bias and Efficacy: Three Sides of the Same Coin"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Functional Dynamics and Single-Molecule Visualization of Signaling
9:00 am - 9:20 am
"Single-Molecule Imaging Reveals the Dynamics and Activation of G Protein-Coupled Receptors"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"The Influence of Lipids on GPCR Conformational Dynamics"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"How Nanodomains of Quantised GPCR Intrinsic Activation Define Macroscopic Agonist Potency and Efficacy"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"Molecular Mechanisms of Metabotropic Glutamate Receptor/Arrestin Coupling"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Single Domain Antibodies and Allosteric Modulators for GPCRs: Discovery and Validation"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"The Alpha-helical Domain of Gα, a New Regulator of the Heterotrimeric G Protein Signaling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
AI-Driven GPCR Analysis and Drug Discovery
7:30 pm - 7:50 pm
"AI Guided Targeting and Engineering of GPCRs"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Drug Design with AI Structures: Separating Truth from Hallucination"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Deciphering Mechanisms of Allostery, Biased Agonism, G Protein Coupling Selectivity of GPCRs"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Interpretable AI for Uncovering Cooperativity and Allostery in Protein Complexes"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Revolutionizing GPCR: Targeted Drug Discovery with Advanced Technologies
9:00 am - 9:20 am
"Precise Targeting of GPCR Signaling"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Dopamine D3 Receptor Structure-Guided Bitopic Drug Design for the Treatment of Substance Use Disorders"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Uncovering the Action of Unconventional GPCR Stimuli"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Activation of Relaxin Receptor Signaling by Diverse Agonists"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"An Engineered Optogenetic Platform to Activate Sub-Cellular GPCR Signalling"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"The Secret Life of G Proteins"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bridging GPCR Signaling and Immune Regulation: Emerging Insights and Therapeutic Avenues
7:30 pm - 7:50 pm
"Modulation of Canonical and Atypical Chemokine Receptor Function by Nanobodies"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Exploiting the GPCR-Chemokine Network to Reprogram the Tumor Microenvironment for Improved Immunotherapy"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Spatial Regulation of GPCR-ERK Signaling"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"The CXCR2 Chemokine Receptor Modulates the Transcriptional Program of Melanocytes During Oncogene Induced Tumorigenesis and Creates a Pro-Tumor Microenvironment"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Late-Breaking Topic
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Central Role of GPCRs in Neuroscience and Neuropharmacology
9:00 am - 9:20 am
"Targeting G Protein Signaling Pathways to Disrupt the Maintenance of Chronic Pain"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Discovery of Novel GPCR Targeted Therapies for Neurological Disorders"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Brain Disorders and Muscarinics: Light at the End of the Tunnel"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Neuropeptide Regulation of Mosquito Blood Feeding and Mating"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Interplay Between the Extracellular and Transmembrane Domains of a Holo-Adhesion GPCR"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Interactions Between the Opioid and PACAPergic Systems: Implications for Headache and Pain Management"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
GPCRs at the Heart of Metabolism: Unlocking New Avenues for Disease Intervention
7:30 pm - 8:10 pm
"GLP-1 Mechanisms in Diabetes, Obesity, Cardiovascular and Kidney Disease"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Metabolites as Signals in Adipose Tissue and Energy Homeostasis"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Cell type-Specific Activation of G12/13 Signaling: Novel Metabolic Functions"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Functional Implications of Biased Signaling at the GLP-1R"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Exploring GPCRs' Impact on Intracellular Signaling Landscapes
9:00 am - 9:20 am
"Subcellular Organization and Reorganization of GPCR Signaling"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"GPCR Signaling: A Spatial Story"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Monoamine Transporters: The Dynamic Modulators of Subcellular GPCR Activity"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Signaling and Non-Signaling GPCRs in Metabolism and Inflammation"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"β-arrestin-Mediated Compartmentalization of Active GPCRs in Membrane Nanodomains via PIP2 Binding"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Regulated Anterograde Transport of Class A GPCRs Uncovered by a Genome-Wide CRISPR Screen and High Content Imaging"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Expanding Horizons in GPCRs in Health and Disease
7:30 pm - 8:10 pm
"The Role of Protein Dynamics in GPCR Signaling"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Targeting Tumor-Suppressive Functions of Gs-Coupled GPCRs in Cancer"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Adhesion GPCRs Regulating Glucose and Energy Homeostasis"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"From Structure to Animal Models of Disease: Biased Agonism at the GLP-1 Receptor"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure