Navigating Efflux Proteins through Fundamental Research and Clinical Translation

Ubiquitously expressed in mammals, plants, and microorganisms, efflux systems play critical roles in mediating chemoresistance in cancers and infectious diseases. These efflux systems maintain crucial permeability barriers for xenobiotics and are key determinants of the pharmacokinetic properties of drugs. They are also exquisitely promiscuous in substrate selection and can transport an impressive range of physiological substrates including lipids, inorganic ions, and signaling molecules. This conference will unravel the latest findings regarding the structure, specificity, function, and regulation of efflux pumps. Presentations will highlight the integrated, multidisciplinary approaches to elucidating key structural and mechanistic attributes, post-translational modifications, and molecular dynamics of the transport proteins. Looking beyond their roles in multidrug resistance, there will also be discussions on the question of how multidrug efflux systems impact physiology and pathophysiology, and how they can respond to cues from the environment. The increased understanding of efflux transporters brings new opportunities for designing precise and powerful medications within reach. Through a series of case studies, participants will highlight how this knowledge of efflux transporters facilitates the development of novel translational approaches to overcoming antimicrobial and anticancer drug resistance and improving the therapeutic outcomes of patients. These medications will target, regulate, or circumvent intricate efflux systems, leading to novel therapeutic interventions that enhance public and global health.

Preceding this conference, there will be a Gordon Research Seminar on Multi-Drug Efflux Systems where early career scientists, postdoctoral fellows, and graduate students will have the opportunity for poster and podium presentations, networking, and career development.