Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Clinical Significance / Pharmacological Impact
3:45 pm - 4:05 pm
"Clinical Significance of Multidrug Efflux Pumps: From Biology to Cancer Therapies"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
"Targeting HIV Reservoirs in Brain by Inhibition of P-Glycoprotein at
the Blood-Brain Barrier"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Application to Drug Discovery
7:30 pm - 7:45 pm
"Biophysical Characterizations of Drug Binding Coupled to ATP Hydrolysis by P-Glycoprotein Reconstituted in Lipid Nanodiscs"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Combination Therapy to Overcome ABC Transport Mediated Chemoresistance in a Colorectal Cancer Mouse Xenograft Model"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Overcoming P-Glycoprotein-Associated Resistance in Chronic
Myelogenous Leukemia with Dasatinib-Based Prodrugs"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Activity of the Dietary Flavonoid, Apigenin, Against Multidrug-Resistant Tumor Cells as Determined by Pharmacogenomics and Molecular Docking"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Phenothiazines Against Antibiotic Resistance: Impact on Efflux Pumps Expression of B. pseudomallei "
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Efflux Pumps as Tools to Increase Biofuel Tolerance in Bacteria"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Keynote Session: Biochemical Studies / Omics Approaches
9:00 am - 9:20 am
"Deciphering the Molecular Details of Substrate Transport and Energy Coupling in Bacterial Multidrug Efflux Pumps"
9:20 am - 9:25 am
Discussion
9:25 am - 9:40 am
"Hoechst 33342 Is a Hidden 'Janus' Amongst Substrates for the Multidrug Efflux Pump LmrP"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
"Transcriptional Activation of Genes Encoding the MacAB Macrolide Efflux Pump by MisR in Neisseria gonorrhoeae "
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Carbonyl Stress Induces the Efflux System MexEF-OprN in Pseudomonas aeruginosa via a Novel Transcriptional Regulator, CmrA"
10:20 am - 10:25 am
Discussion
10:25 am - 10:40 am
"Genomic and Transcriptomic Profiling of Resistant CEM/ADR-5000 and Sensitive CCRF-CEM Leukaemia Cells for Unravelling the Full Complexity of Multi-Factorial Multidrug Resistance"
10:40 am - 10:45 am
Discussion
10:45 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Development Panel
1:30 pm - 2:30 pm
Panel Discussion
Career Development Panel
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes