Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
In Silico Approaches and Methods in Structural Biology
3:15 pm - 3:25 pm
"Toward Synthetic Membranes: Functional Reconstitution of Two ABC Exporters in Hybrid Lipid-Polymer Vesicles"
3:25 pm - 3:30 pm
Discussion
3:30 pm - 3:40 pm
"Functional Difference Between MexXY-OprM and MexXY-OprA RND Efflux Systems in Pseudomonas aeruginosa "
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
"Arylhydrocarbon Receptor-Mediated Signaling of ABC Transporters and Solute Carriers in Human Renal Proximal Epithelial Tubular Cells and Proximal Renal Tubules from Killifish"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Molecular Mechanisms Driving to Multi-Drug Efflux of Antibiotics or Anti-Cancer Drugs
5:30 pm - 5:45 pm
"Characterization and Regulation of a Novel Efflux Pump from the Major Facilitator Superfamily in Streptomyces coelicolor M145"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
"Drug Resistant Cancer Cells Can Be Targeted by Oridonin"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
"Susceptibility of Pseudomonas aeruginosa to Antibiotics Can Be Compromised by Essential Oils"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
"ATP-Dependent Substrate Transport by the ABC Transporter MsbA Is Proton-Coupled"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Single Amino Acid Changes in MtrD Impact Susceptibility of Neisseria gonorrhoeae to Macrolides"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"TtgABC and a Novel RND Efflux Pump ParXY Are Co-Regulated by a Two-Component System in Pseudomonas putida "
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Keynote Session: Physiological Role of Efflux Systems / Insights into Drug Discovery and Development
9:00 am - 9:20 am
"A Battle of the Titans: Strategies to Fight Multidrug Resistance in Cancer"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
"Molecular Mechanism Underlying P-Glycoprotein Efflux of Anthracycline Drugs"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Discovery of New Efflux Pump Inhibitors that Interact with AcrA of the Escherichia coli AcrAB-TolC Efflux Pump"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
"Substrates of the Anaerobic Efflux Pump MdtEF-TolC"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Investigating the Regulatory Circuits Controlling Multidrug Efflux Pump Expression in Acinetobacter baumannii "
10:20 am - 10:25 am
Discussion
10:25 am - 10:35 am
"Reconstitution of the Activity of Efflux Pump into Proteoliposomes"
10:35 am - 10:40 am
Discussion
10:40 am - 10:50 am
"Towards Single-Molecule Characterization of the Alternating Access Mechanism in MdfA"
10:50 am - 10:55 am
Discussion
10:55 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Scientific Networking and Grant Writing
1:30 pm - 2:30 pm
Panel Discussion
Scientific Networking and Grant Writing
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes