Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Biology and Bioengineering as a Platform for Change
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:25 pm
"Synthetic Biology in the Construction and Control of Artificial Tissues"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
"Using Structural Changes in Mitochondrial Aging to Create a Thriving Laboratory Culture."
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Spatially Patterned, 3D In Vitro Models of Cancer Metastasis to Bone for Elucidating Key Drivers of Metastasis and Drug Discovery"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biology and Bioengineering of Aging in the Musculoskeletal System
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Cellular Dynamics in Bone Development and Aging"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Accumulated DNA Damage in Chondrocytes is Reduced by Activation of Sirtuin 6"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Engineering Immune-Modulatory Regenerative Medicine in Aging"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
"Altered Inflammatory Responses with Aging in an In Vitro Bone-Tendon-Muscle Model"
10:55 am - 11:00 am
Discussion
11:00 am - 11:25 am
"Revisiting Isolation of Meniscus Cells for Tissue Engineering"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Can We Reverse the Effects of Osteoarthritis on Aging Muscle?"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Musculoskeletal Pain: Causes and Cures
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"General Principles in Pain Processing: Application to problems in Musculoskeletal Pain"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Pre-surgical Brain Properties Predicting Pain Persistence Following Total Knee Replacement Surgery"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Exercise and Musculoskeletal Pain"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Spatial Context in the Musculoskeletal System
This session will explore the role of spatial control and context in the biological and physical function of the musculoskeletal system using novel bioengineering and imaging approaches.
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Rapid Evolvement and Specialization of the Primitive Matrix in Embryonic Cartilage at the Nanoscale"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Multiscale Quantification of Spatial Bone Mechanobiology"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Defining Mechanical Thresholds for Collagen Microdamage in Soft Musculoskeletal Tissues"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Spatial Analysis of the Endosteal Niche"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Waves, Flows and Gradients in Zebrafish Bone Regeneration"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Predicting Anterior Cruciate Ligament (ACL) Failure Load with MRI and Machine Learning as a Prospective Imaging Biomarker for Revision Surgery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tracking Musculoskeletal Histories Over Time
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Practical Tools for Management of Progenitor Cell Heterogeneity"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Circadian Rhythms in Health and Disease of the Musculoskeletal System"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Investigating the Regulatory Control of Human Skeletal Development, Evolution, and Disease Risk"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Multiscale Metabolism in Musculoskeletal Tissue Crosstalk
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Metabolic Control of Osteoclast Recycling and Osteomorph Formation"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Understanding Joint Homeostasis and Pathophysiology Using Metabolomic Profiling"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Leptin Regulates Fat-Cartilage Crosstalk in Osteoarthritis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Role of CNS Regulatory Genes in Skeletal Development and Bone Maintenance"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Brain Derived Osteogenic Factor: A Brain and Bone Connection"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Sex Specific Mediators of PTOA Pain and Inflammation in Adult Mice"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Enlisting the Immune System for Musculoskeletal Health
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Immune-Modulatory Role of Prx1+ Mesenchymal Cells"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Mesenchymal Stromal Cell-derived Extracellular Vesicles for Targeting Inflammation and Senescence in Osteoarthritis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Macrophage-Osteoclast Lineage Autonomously Dials Down Inflammasome Pathways to Survive"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Multiscale Musculoskeletal Mechanobiology
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Multiscale Definition of Pro-fibrotic Regulation of Tendon Healing"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Using Innovative Biotech to Test, Probe, and Prioritize Hypotheses - Case Studies in Multiscale Mechanobiology"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Tissue-Interfacing Automatic Stimulation Devices for Muscle Regeneration & Rehabilitation"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Multiscale Mechanobiology of Cartilage Morphogenesis: How Collective Cell Behaviours Determine Joint Shape Under Normal and Abnormal Loading"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"A Cartilaginous Mechanostat"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Osteocytes with a 3D Dendritic Network in Engineered Bone Tissue on a Chip"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Musculoskeletal Biology and Biomaterial
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"CRISPR for Discovery, Design, and Development of Musculoskeletal Therapeutics"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Engineering Biomaterials for Targeted Therapeutic Delivery in the Joint"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Biomaterials for Expansion of Potent Mesenchymal Stromal Cells for Musculoskeletal Repair"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
