Mycotoxins and Phycotoxins

Gordon Research Conference

June 24 - 29, 2001
Chairs and
Vice Chairs and

Conference Program

Sunday
Session 1.
Evening 		Novel and Recurring Human Toxicoses
Chair: Wayne Bryden, University of Sydney, Sydney, Australia
Discussion Leader: Mark Poli, USAMRIID, Frederick, MD
7:30 pmWelcome
7:40 pmOverview
7:50 pmAzaspiracid Poisoning: Aetiology and Distribution of the Shellfish Toxins Responsible for a New Toxic Syndrome
Kevin James, Ecotoxicology Research Unit, Cork Inst. of Technology, Cork, Ireland
8:20 pmIs the High Prevalence of Neural Tube Defects Along the Texas-Mexico Border Associated with the Consumption of Corn-Based Foods?
Kate Hendricks, Infectious Disease Epidemiology & Surveillance Division, Texas Department of Health, Austin, TX
8:50 pmPectenotoxin: An Association with Human Shellfish Poisoning in Australia and Canada?
Michael Quilliam, NRC, Halifax, Nova Scotia, Canada
9:20 pmDiscussion / Hot topic*
9:45 pmSocial
Monday
8:45 am Group Photo
Session 2.
Morning		New Frontiers: Toxicogenomics, Biochips and Electronic Noses
Chair: Gary Payne, North Carolina State University, Raleigh, NC
Discussion Leader: Gerry Plumley, University of Alaska, Fairbanks, AK
9:00 amIntroduction
9:05 amKeynote Lecture:Toxicogenomic and Proteomics- Tools Of Discovery For The Research Scientist
James Selkirk, NIEHS, Research Triangle Park, NC
10:00 amDiscussion
10:10 amCoffee Break
10:35 amOverview
10:45 amDifferentiation Between Mycotoxigenic and Non-Mycotoxigenic Strains of Fungi Based on Their Volatile Production Patterns Using an Electronic Nose System
Naresh Magan, Cranfield University, UK
11:15 amMultianalyte Detection Using Electronic Tongues
John McDevitt, University of Texas, Austin, TX
11:45 pmDiscussion / Hot topic*
12:30 pmLunch
4:30 pmPoster Session I
6:00 pmDinner
Session 3.
Evening 		New Developments in Metabolism and Detection
Chair: Vera Trainer, NOAA, National Marine Fisheries Service, Seattle, WA
Discussion Leader: Mary Trucksess, CFSAN, USFDA, Washington, DC
7:30 pm Overview
7:40 pmFluorescence Polarization As a Tool for the Determination of Fumonisin and Deoxynivalenol in Cereal Grains
Chris Maragos, USDA, Peoria, IL
8:10 pmMetabolism of Brevetoxins in Shellfish
Steve Musser, USFDA, Washington, DC
8:40 pmAcylation of Hydrolyzed Fumonisins by Ceramide Synthase to Form Toxic N-Acyl-Metabolites
Michaela Hartl, BASF AG, Limburgerhof, Germany
9:10 pmDiscussion / Hot topic*
Posters / Social
Tuesday
Session 4.
Morning		Mode of Action and Molecular Targets for Toxins: New Approaches and Advances
Chair: James Pestka, Michigan State University, East Lansing, M
Discussion Leader: Tom Murray, University of Georgia, Athens, GA
9:00 amOverview
9:10 amA Genomic Approach to Understanding Fumonisin-Induced Toxicity in Mouse Liver
Chris Corton, CIIT, Research Triangle Park, NC
9:40 amInflammation Augments Acute Hepatotoxicity Caused by Mycotoxins
Pattie Ganey, Michigan State University, East Lansing, MI
10:10 amDiscussion
10:20 amCoffee Break
10:40 amMechanism of Action of the Putative Pfiesteria Toxin: Activation of a P2X7 Receptor Pathway
John Ramsdell, Marine Biotoxins Program, NOAA National Ocean Service, Charleston, SC
11:10 amMaitotoxin Activates a Non-selective Cation Channel and a P2C/P2X7-like Cytolytic Pore
William Schilling, Case Western Reserve University, Cleveland, OH
11:40 amMechanisms Of Action of Polyether Toxins on Sodium Channels
David Adams, University of Queensland, Brisbane, Australia
12:10 pmDiscussion / Hot topic*
12:30 pmLunch
4:30 pmPoster Session I
6:00 pmDinner
Session 5.
Evening		Toxin Chemistry and Analysis
Chair: John Apsimon, Carleton University, Ottawa, Canada
Discussion Leader: Robert Gawley, University of Miami, FL
7:30 pmOverview
7:40 pmPurification and Characterization of a Toxin from Pfiesteria piscicida
Peter Moeller, Marine Biotoxins Program, NOAA National Ocean Service, Charleston, SC
8:05 pmChlorinated Byproducts from the Treatment of the Cyanobacterial Toxin, Cylindrospermopsin
Glen Shaw, National Research Centre for Environmental Toxicology, Queensland, Australia
8:30 pmAssessing Chronic Exposure to Fumonisin Mycotoxins: The Use of Hair as a Suitable Non-Invasive Matrix
Vikash Sewram, Medical Research Council, PROMEC Unit, Tygerberg, South Africa
8:55 pmDiscussion
9:05 pmInvited student presentations :
Chair W.F.O. Marasas, Medical Research Council, South Africa
(TBA: two students to be selected from poster presentations)
9:30 pmDiscussion
9:45 pmPosters / Social
Wednesday
Session 6.
Morning		Cellular and Environmental Control of Toxin Production
Chair: Deepak Bhatnagar, USDA/ARS, New Orleans, LA
Discussion Leader: Don Anderson, Woods Hole Oceanographic Institute, MA
9:00 am Overview
9:10 amPolyketide Biosynthesis by Dinoflagellates: Molecular Genetic Perspectives
Kelly Rein, Florida International University, Miami, FL
9:40 amCellular and Sub-Cellular Localization of Enzymes Involved in Aflatoxin Synthesis in Aspergillus parasiticus
John Linz, Michigan State University, East Lansing, MI
10:10 amDiscussion
10:25 amEvaluations
10:30 amCoffee Break
11:00 amControl of Toxin Production in Algal Cells by External Nitrogen and Phosphorus Concentrations
Edna Graneli, University of Kalmar, Kalmar, Sweden
11:30 amImpact of Corn Kernel Environment on Gene Expression and Fumonisin Biosynthesis in Fusarium verticillioides
Charles Woloshuk, Purdue University, West Lafayette, IN
12:00 pmDiscussion / Hot topic* / Evaluations
12:30 pmLunch
4:30 pmPoster Session II
6:00 pmDinner
Session 7.
Evening		Biological and Genetic Control Measures
Chair: Jonathan Duvick, Pioneer Hi Bred Seed Int., Johnston, IA.
Discussion Leader: Nancy Keller, University of Wisconsin, Madison, WI
7:30 pmOverview
7:40 pmSurvey of the Family Bacillaceae for Biocontrol of the Endophytic State of Fusarium moniliforme in Maize and in planta Fumonisin Reduction
Charles Bacon, USDA/ARS, Athens, GA
8:10 pmRibosomal Protein Transgene to Increase Plant Tolerance to Trichothecenes
Linda Harris, Agriculture and Agri-Food Canada, Ottawa
8:40 pmGenomic Analysis of Toxin Production by Plant Pathogenic Fungi
Olen Yoder, Torry Mesa Research Institute, San Diego, CA
9:10 pmDiscussion / Hot topic*
Posters / Social
Thursday
Session 8.
Morning		Novel Toxin Outbreaks: Environmental Implications
Chair: Benjamin Suarez-Isla, University of Chile, Santiago
Discussion Leader: Ken Voss, USDA/ARS Athens, GA
9:00 amOverview
9:10 amWidespread Environmental Impacts of Domoic Acid on the California Coast
Mary Silver, University of California at Santa Cruz, CA
9:40 amBrevetoxin Production by Chattonella in Delaware
Carm Tomas, University of North Carolina, Wilmington, NC
10:10 amDiscussion
10:20 amCoffee Break
10:40 amToxicoses in Cattle Associated with Penicillium Species
David Miller, Carleton University, Ottawa, Canada
11:10 amDomoic Acid in Scotland: Environmental, Regulatory and Political Implications
Susan Gallacher, FRS Marine Laboratory, Aberdeen, Scotland
11:40 amDiscussion / Hot topic*
12:00 pmBusiness Meeting
12:30 pmLunch
4:30 pmPoster Session II
6:00 pmDinner
Session 9.
Evening		Populations at Risk: Contributing Factors and Future Directions
Chair: Gerrit Speijers, National Institute of Public Health and Environment, Bilthoven, Netherlands
Discussion Leader: Bob MacPhail, NHEERL, EPA, Research Triangle Park, NC
7:30 pmOverview
7:40 pmRisk Assessment of Cyanobacterial Toxin Exposure
Ian Falconer , CRC for Water Quality and Treatment, Adelaide, Australia
8:10 pmFumonisin-Induced Perturbation of Folate Transport and Neural Tube Development
Victoria Stevens, Emory University, Atlanta, GA
8:40 pmReduction of Mycotoxin Health Risks Through the Use of Genetically Engineered Plants
Bruce Hammond, Monsanto Company, St. Louis, MO
9:10 pmDiscusssion / Closing Remarks
9:45 pmSocial

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