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SUNDAY, MAY 7
Arrival
posters go up
Dinner 6 - 7 pm
(7:15 - 9:15 pm)
Hans Werner Mueller (Düsseldorf), Discussion Leader
- Shoichiro Tsukita (Kyoto) Claudin family.
- Bob Lazzarini (for Alex Gow) (New York) OSP mediates the formation of parallel tight junction fibrils.
- Tim Coetzee (Farmington) Myelin membrane subdomain structure and function.
- Ian Duncan (Madison) Cytoskeletal abnormalities in oligodendrocytes of the taiep rat mutant.
MONDAY, MAY 8
Inherited & Acquired Myelin Diseases
(9:00 - 12:30 am)
Steven Scherer (Philadelphia) & Doug Arnold (Montreal), Discussion Leaders
- Hugo Moser (Baltimore) Human genetic disorders of myelin: Adrenoleukodystrophies.
- Volkmar Gieselmann (Kiel) Arylsulfatase knockout mice as a model for metachromatic leukodystrophy
- Henry McFarlane (Washington D.C.) Implications of MRI on our understanding of the MS lesion.
- Art Warrington (Rochester) Immunoglobulin Modulation of CNS Repair.
- Bill Hickey (Lebanon) B-cell Entry in the Pathogenesis of CNS disease.
Informal afternoon sessions
Poster Session 4 - 5 pm
(5 - 7:30 pm)
Monique Dubois-Dalcq (Paris), Discussion Leader
- Oliver Brüstle (Bonn) Embryonic stem cell-based myelin repair.
- Evan Synder (Boston) Neural stem cells in development and disease.
- Ole Isacson (Boston) Development of neural and stem cells in transplantation to the adult CNS.
- Hans Keirsted (Irvine) Remyelination following transplantation of glial-committed neural precursors.
- Steve Goldman (Cornell) Oligoneogenic progenitor cells of the adult human white matter.
Poster Session 9 - 10:30 pm TUESDAY, MAY 9
Experimental Genetic Models of Dys/Demyelinating Disease
(9:00-11:00 am)
Boris Zalc (Paris) & Kaz Ikenaka (Okazaki), Discussion Leaders
- Kuni Suzuki (Chapel Hill) Cross-breeding of the twitcher mouse model.
- Wendy Macklin (Cleveland) Transgenic approaches to investigating oligodendrocytes.
- Larry Wrabetz & Laura Feltri (Milan) Gain of P0 function: Mouse models of hereditary neuropathies.
- Dies Meijer (Rotterdam) Transgenic analysis of SCIP/Oct6.
- (Short Comment). Alan Peterson (Montreal) Promoter expression.
Endogenous Mechanisms of Remyelination
(11:15 am - 12:30 pm)
Richard Reynolds (London), Discussion Leader
- Mary Dawson (London) Characterization of NG2-expressing cells in the adult rat and human CNS.
- Arthur Butt (London) Adult progenitors in the normal undamaged CNS.
Informal afternoon discussions
Poster Session 4 - 5 pm
(5-7:30 pm)
Peter Brophy (Edinburgh), Discussion Leader
- Patrick Doherty (London). Identification of functional motifs in N-cadherin that specify homophilic binding and signal transduction.
- Terri Wood (Hershey) Growth factor interactions in oligodendrocyte generation.
- Rashmi Bansal (Farmington) Functional analysis of the fibroblast growth factor receptors.
- Charles ffrench-Constant (Cambridge) Integrin function during myelination.
- Tim Vartanian (Boston) The Erb-2 gene is necessary for the development of mature oligodendrocytes.
Poster Session 9 - 10:30 pm WEDNESDAY, MAY 10
Transcription Factors in Myelin-forming Cell Differentiation
(9 am-10:30 pm)
Chuck Stiles (Boston), Discussion leader
- David Rowitch (Boston) Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH factors in the CNS.
- Lynn Hudson (Washington D.C.) Application of microarrays to myelin biology and disease.
- Short Talk: Hideuka Okano (Tokyo) Transcriptional regulation in myelin-forming cells.
Additional Frontiers
(11:00 - 12:15 am)
Melitta Schachner (Hamburg), Discussion Leader
- Mark Ellisman (San Diego) Electron tomography of the node of Ranvier
- Roger Schnaar (Baltimore) Gangliosides as functional MAG ligands.
- Randy McKinnon (Piscataway) Signal transduction in oligodendrocyte development.
Immunology, or Not, of Demyelinating Disease
(5:30 - 7:30 pm)
Chris Linington, Discussion Leader
- Chris Linington (München) Genetic regulation of MOG expression modulates remyelination in EAE.
- Rudolph Martini (Würzburg) Demyelination in heterozygous P0-deficient mice: Functional involvement of immune cells.
- Anura Rambukkana (New York) Demyelination in the absence of immune response: A lesson from Microbacterium leprae infection.
- John Steeves (Vancouver) Transient immunological suppression of CNS myelin to facilitate axonal regeneration.
Poster Session 9 - 10:30 pm THURSDAY, MAY 11
Regeneration & Repair of Neurons
(9:00 - 11:00 am)
Marie Filbin & Keichii Uyemura, Discussion Leaders
- Joel Levine (Stony Brook) Inhibitory Proteogylcans & Glial Scars.
- Lisa McKerracher (Montreal) Overriding myelin-derived growth inhibition to stimulate axon regeneration in the CNS.
- Marie Filbin (New York) Overcoming Inhibitors of Regeneration; Clues from Development.
- John Steeves (Vancouver) Transient Immunological Suppression of CNS Myelin to Facilitate Axonal Regeneration.
- Short Talk: Thomas Oertel (Zurich) No-Go? A novel neurite growth inhibitory protein.
Deconstructing Myelin Genes
(11:30 am - 12:30 pm)
Ueli Suter, Discussion Leader
- Bob Skoff (Detroit) Myelin genes PLP and MBP are expressed in many tissues.
- Tony Campagnoni (Los Angeles) PLP and Golli-MBP in immune response.
Molecular Structure of the Node of Ranvier
(5 - 7:30 pm)
Peter Shrager (Rochester), Discussion Leader
- Ori Peles (Rehovot) Caspr protein family and the organization of axonal domains in myelinated fibers.
- Lori Isom (Ann Arbor) Sodium channel ß subunits are cell adhesion molecules: interactions with extracellular matrix and the cytoskeleton
- James Salzer (New York) Initial events in node and paranode formation.
- Stephen Lambert (Worcester) Differential trafficking of ankyrins and their binding proteins in axonal polarity.
- Short Talk: S. Rock Levinson (Denver) Differential localization of sodium channel isoforms at the node of Ranvier
- Short Talk: François Couraud (Marseille) Interactions between neuronal sodium channels and the cytoskeleton.
FRIDAY, MAY 12
Morning Departure
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