Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Evolution of Myelin
We will take a look back about 600 million years. The appearance of myelin is an astounding example of convergent evolution as oligodendrocytes and Schwann cells both appear in vertebrates above the jawless fishes. This session will cover evolutionary origins of prototype myelin and myelinating cells of the CNS and PNS.
7:40 pm - 8:00 pm
"Breaking the Code of Myelination"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"The Evolution of Myelin in Invertebrates"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Glial Ensheathment of Axons in a Non-Myelinated Vertebrate Species"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Mechanisms of Axon Ensheathment"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Fetal Myelin
Does myelin have relevance in the fetus? What is the remyelination potential of fetal versus adult type oligodendrocytes? This session will cover fetal origins of oligodendrocytes in human brain. Fetal myelin is particularly important in the PNS of animals that need to move fast at birth. This session will also cover fetal and iPSC-derived stem cells being tested for cell-based myelination therapies.
9:00 am - 9:20 am
"Neuron-Glia Interaction in the Human Ganglionic Eminence"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Using iPS Cells to Understand the Basis for Remyelination Failure in MS"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Developmental CNS Myelination Is Dependent on Axon Caliber, but Not Dynamic Neuronal Signaling"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"PAK1 Regulation of Oligodendrocyte Differentiation and Myelination"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"A Dynamic Study of Early Nodal Formation in the Central Nervous System"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Glial-Glial Interactions in Developmental Myelination"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Glial Regulation of Neural Circuit Formation and Function"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Myelinating Schwann Cells Restrict Axonal Calibers via CMTM6"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Myelin Development in Early Childhood
Session in memory of Dr. Ben Barres . This session will cover mechanisms of developmental myelination, ranging from transcriptional regulation to axo-glia interactions. This scientific session is dedicated to Dr. Ben Barres in celebration of his contribution to the field and dedication to training young scientists.
7:30 pm - 7:50 pm
"Negative Regulators of Myelination"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Chromatin Remodeling Control of Myelination"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Environmental Effects on Myelination After Perinatal White Matter Injury"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"A Novel Inhibitory Pathway on CNS Myelination"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"How Do Oligodendrocytes Make Microtubule Branches?"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Adolescent Myelin: Developmental Origins of Psychiatric Diseases
Parents with an adolescent child might easily appreciate that the brain undergoes catastrophic rewiring, but there is also a massive increase in myelination. In pediatrics and child psychiatry there growing recognition that mental health manifestations can be traced to adolescence. This session will cover the growing body of evidence for white matter remodeling in the juvenile and its association with psychiatric illness.
9:00 am - 9:20 am
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Growth of White Matter in the Adolescent Brain: Myelin or Axon?"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Diverse Patterns of Myelination Along Individual Axons in the Adult Cerebral Cortex"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Functional Heterogeneity of Oligodendrocytes in the Central Nervous System"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Interneurons and OPCs as Romeo and Juliet During Cortical Development"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Dynamics of Myelin Formation in Development and Adult"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"On the Relationship Between Myelination of Long-Range Projections and Their Short Term Functional Plasticity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Microglial TG2 Drives Myelination and Myelin Repair via GPR56/ADGRG1 in Oligodendrocyte Precursor Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Myelin Homeostasis
Myelin, once thought to be an inert insulating membrane, is now accepted as a dynamic structure that changes over time and with environmental stress. This session will discuss concepts related to adult myelin composition and the cross talk between axons and oligodendrocytes and Schwann cells as well as intrinsic mechanisms that regulate myelin adaptations.
7:30 pm - 7:50 pm
"Cellular Interaction Supporting Axonal Energy Metabolism"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Upholding White Matter and Nerve Integrity by Metabolic Signaling in Enwrapping Glia"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"In Vivo Imaging in Zebrafish Reveals Novel Mechanisms of CNS Myelination"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Uncovering Mechanisms of Myelin Plasticity in the Live Brain"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Dynamics of Myelin Turnover in the Adult Mouse CNS"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Myelin Disease: Mechanisms and Treatments
There have been remarkable clinical advances in the treatment of myelin diseases like MS, but still many hurdles to overcome. This session includes international leaders of clinical trials for MS and genetic myelin disorders. We will cover mechanisms of myelin pathology in the adult brain and PNS.
9:00 am - 9:20 am
"Treating Demyelinating Peripheral Neuropathies: The Key Role of Schwann Cell Mitochondria"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Pediatric Leukodystrophies"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Distinct Microglia and Monocyte-Derived Macrophage Functions During Remyelination Revealed by RNAseq"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
"Prohibitin 1 Preserves Axon and Myelin Integrity in the Peripheral Nervous System"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
"Oligodendrocyte-Encoded Potassium Channel Kir4.1 Function Is Essential for White Matter Integrity"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Do We Know How and if Treatments Work in Multiple Sclerosis?"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Oligodendroglial Support of Axonal Energy Metabolism: Relevance for Disease"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Remyelination of Specific Axonal Domains in the Somatosensory Cortex"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Rogue Myelin
Myelinating cells are not always benevolent. Several lines of evidence demonstrate that gliomas are generated from oligodendrocyte precursors. Glial sub-type characteristics are hijacked for glioma to exploit their host environment (to the detriment of the host). This session will cover glioma origins, impact of treatments on white matter including toxic leuko-encephalopathies.
7:30 pm - 7:50 pm
"Crowd Control Going Rogue: Cell Competition in Gliomagenesis from Oligodendrocyte Progenitor Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Saving Time in a Bottle: White Matter Plasticity, Neural Communication, and Brain Repair"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Dysregulated Gliogenesis Is a Driver of Malignant Glioma"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Consequences of Gut Microbiota-Induced Changes on Myelination"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Biochemically-Altered Myelin Pathology Triggers Autoimmune Demyelination"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Aging Myelin
How does white matter age, what changes take place that can affect day-to-day function of the growing number of individuals living well past 70 years of age? New evidence shows that common conditions like senile dementia have important white matter components and white matter infarct (“stroke”) is another important example. This session will cover changes in aging myelin structure, function and disease.
9:00 am - 9:20 am
"Endothelial Dysfunction and White Matter Vulnerability in Cerebral Small Vessel Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Age-Related Changes in Translational Expression of Oligodendrocytes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Oligodendrocytes, Aging, Epigenetics, DNA Methylation"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Formation and Remodelling Dynamics of Axon Myelination Patterns Revealed by In Vivo Imaging"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"The Role of the Subcortical Cytoskeleton in the Organization of the Nodes of Ranvier, and the Interplay Between the Neuronal and the Glial Cytoskeleton"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Spectrin Cytoskeletons Converge on Nodes of Ranvier"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"MCT1 in Schwann Cells Is a Metabolic Mediator of Sensory Axon Myelination During Aging"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Myelin Regeneration and New Therapies
There are many disorders of myelin yet to be addressed with new therapies. What are the approaches being tested in therapy of genetic and autoimmune diseases? Moreover, how do we set up an ideal clinical trial? This session will cover mechanisms of regeneration and how to enhance this after myelin insult in the developing and adult CNS and PNS.
7:30 pm - 7:50 pm
"Gene Therapy Approaches Targeting Myelinating Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Oligodendrocyte Precursor Cells Are Co-Opted by the Immune System to Cross-Present Antigen and Mediate Cytotoxicity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Adaptive Immunity in CNS Remyelination. A Key Role for Regenerative T Regulatory Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"How Adaptive Immunity Shapes the Remyelination Process"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure