Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Natural Products in the Service of Human Health
7:40 pm - 8:20 pm
"The Economics of Antibacterial Drug Development, Getting Biotech and Big Pharma Back in the Game"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Recent Advances in Natural Product and Bioactive Compound Synthesis"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Discovery and Chemistry of New Secondary Metabolites
9:00 am - 9:30 am
"Mining Microbial Metabolome: A New Paradigm in Natural Products Discovery"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Utilization of Hydrophobic TAGs for Synthesis of Unique Peptide Natural Products"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Insights from Screening 10,000 Marine Natural Products Extracts for Antimicrobial Activity"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Microbial Biosynthesis of Complex Plant-Derived Natural Products"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Constructing Architecturally Complex Molecules
7:30 pm - 8:00 pm
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Complex Alkaloid Total Synthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Conformation-Activity Relationships in Complex Natural Products Inspired by Biosynthesis"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Methods Development in Pursuit of Bioactive Molecules
9:00 am - 9:30 am
"Oxygen Driven Fragment Coupling by Activation of C-H, N-H and O-H Bonds"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"NRPS-Engineering for the Modification and De Novo Generation of Peptide Natural Products"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"The Sweet Taste of Replacing Hydrogen with Glucose: Catalytic Synergy for Chemoselective Enzymatic Reductions"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Deploying Natural Design Principles for Cell-Based Factories"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances in Synthetic Biology and Chemistry
7:30 pm - 8:00 pm
"Chemical Tools to Intercept and Interrogate Bacterial Communication Pathways"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Organic Reactions Inspired by the Chemistry of Gold"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Discovery of TAK-243: An Investigational, First-in-Class Inhibitor of the Ubiquitin Activating Enzyme"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Paradigm Shifting Technology
9:00 am - 9:30 am
"Using Old Chemistry to Find New Cancer Targets"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Engineered Protein Switches for Studying Dynamic Cellular Processes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Improving Our Approach Towards Gram-Negative Drug Discovery"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Innovation in the Synthesis of Complex Pharmaceuticals"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Novel Benzamide Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Complex Molecular Drug Discovery
7:30 pm - 8:00 pm
"Lifting the Body's Energy Embargo"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Design, Syntheses and Studies of Antibiotics to Circumvent Bacterial Resistance"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Inhibitors of HIV-1 Maturation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Natural Product-Inspired Medicinal Chemistry
9:00 am - 9:30 am
"Discovery, Target Identification and Validation of a Novel Class of Potent Highly Selective Anti-Colon Cancer Small Molecules"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Can We Beat Nature? Rational Design, Chemical Syntheses and Molecular Mechanisms of Action of New Antibiotics Based on Old Natural Products"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Design of Technology-Compatible Cyclic Peptide Scaffolds with Oral Bioavailability"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Optimization of the Arylomycin Natural Product into Gram-Negative Antibiotics"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: The State-of-the-Art of Discovery in Natural Products
7:30 pm - 8:15 pm
"Natural Product Sciences in Modern Drug Discovery and Paths to the Future"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:10 pm
"Studies in Natural Product Synthesis"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure