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Natural Products and Bioactive Compounds

Gordon Research Conference

Natural Products: Diversity and Integration

July 28 - August 2, 2024

Chair

Vice Chairs

and

Proctor Academy

204 Main Street

Andover, New Hampshire, United States

Venue and Travel Information

Conference Description

The Natural Products and Bioactive Compounds GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Natural products have played a critical role in the development of synthetic and structural chemistry, have been indispensable for the elucidation of biological pathways, e.g. in neuroscience and immunology, and have posed fascinating biosynthetic questions. Small metabolites play crucial roles within and in between organisms, i.e., in physiology and ecology. A large proportion of clinically used drugs are either natural product themselves or are natural-product derived. As such, natural products continue to drive new developments in a wide variety of fields, ranging from computational chemistry, synthetic methodology and synthetic design, to enzymology, molecular biology, structural biology, genome mining and computational biology. The conference will feature talks and discussions on these topics, reflecting the diversity, vibrancy, and integrating power of natural products research.

Related Meeting

This GRC will be held in conjunction with the "Natural Products and Bioactive Compounds" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: The Total Synthesis of Complex Natural Products Discussion Leader:
7:40 pm - 8:20 pm	"Catalyst Control in Complex Natural Product Synthesis"
8:20 pm - 8:35 pm	Discussion
8:35 pm - 9:15 pm	"Total Synthesis of Highly Oxygenated Natural Products"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Rising Stars in Natural Products Chemistry Discussion Leader:
9:00 am - 9:30 am	"Anaerobic Heteroatom Transfer Reactions Promoted by Photoexcited 1,3-Dipoles"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Advances in Late-Stage Peptide Modification Chemistry: Inspiration from Nature"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"The Chemistry of Securinega Alkaloids"
11:20 am - 11:30 am	Discussion
11:30 am - 12:00 pm	"The Devil Is in the Details: Total Syntheses of Cyclotaxanes"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Medicinal and Process Chemistry of Natural Products and Bioactive Compounds Discussion Leader:
7:30 pm - 8:00 pm	"New Modalities Enabling Target Validation"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"A Med Chem Tale of Making Lemonade from Lemons"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Process Development of CDK2 Selective Inhibitor PF-07104091"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Peptides, Proteins, and Their Modifications Discussion Leader:
9:00 am - 9:30 am	"Discovery and Development of Disulfide Constrained Peptides"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Redox Economic Alkaloid Synthesis"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Chemistry and Biology of the C-Terminal Cyclic Imide Modification"
11:20 am - 11:30 am	Discussion
11:30 am - 12:00 pm	"New Methods for the Chemical Synthesis of Post-Translationally Modified Peptides and Proteins"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Lipids, Carbohydrates, Cell Walls, and Their Modifications Discussion Leader:
7:30 pm - 8:00 pm	"A Collaborative Total Synthesis of Darobactin"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Synthetic Studies Toward Garsubellin A and Exiguamines"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Targeting Diacylglycerol Kinase to Overcome MRSA"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Novel Synthetic Strategies and Methodologies Discussion Leader:
9:00 am - 9:30 am	"Deconstructive Homologation of Ethers and Amides"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Enantioselective Catalysis and Electrocatalysis of Radical Reactions"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Synthetic Studies Toward Tubingensin B"
11:20 am - 11:30 am	Discussion
11:30 am - 12:00 pm	"Difunctionalization of Alkenes with Carbon Sources"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Strategies and Tactics for Complex Natural Product Total Synthesis Discussion Leader:
7:30 pm - 8:00 pm	"Curiosity, Challenges and Discovery in Natural Product Synthesis"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	"Adventures in the Total Synthesis and Chemical Microbiology of Marine Natural Products"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	"Neuromodulating Alkaloids from Millipede Defensive Secretions"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Genomes and Chemical Connectomes Discussion Leader:
9:00 am - 9:30 am	"Genome Mining for Selenometabolites"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Computational Genomics to Unravel the Diversity and Distribution of Bacterial Natural Products"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Biosynthesis of Elaborate Polyketides Encoded by Animal Genomes"
11:20 am - 11:30 am	Discussion
11:30 am - 12:00 pm	"Approaches Towards Innovative Anti-Infectives from Microbes"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: The Origin and Meaning of Natural Products Discussion Leader:
7:30 pm - 8:15 pm	"Radical Mechanisms for Biological Methylation"
8:15 pm - 8:30 pm	Discussion
8:30 pm - 9:15 pm	"Mining Human-Associated Bacteria for Biologically Active Small Molecules"
9:15 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Conference Links

Conference History Natural Products and Bioactive Compounds (GRS)

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