Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The Chemistry Biology Interface
7:40 pm - 8:20 pm
"Chemical Probes Uncover a New Anti-Bacterial Strategy"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Hijacking Molecular Machines to Reveal New Chemistry and New Biology"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Early Career Investigator Presentations
9:00 am - 9:20 am
"New Avenues in Cyclase Phase Total Synthesis"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Biosynthesis of Natural and New-to-Nature Glycosides in Engineered Yeast"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Novel Strategies for Complex Bioactive Molecule Synthesis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Synthesis of Amino Acid-Derived Natural Products"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Total Synthesis of Sulfur-Containing Sesquiterpenoid Natural Products"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Efficient Natural Product Synthesis via a Common Polyfunctional Building Block Approach"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Medicinal Chemistry of Natural Products and Bioactive Compounds
7:30 pm - 8:00 pm
"Adventures in Chemistry: Drugging KRAS Past and Present"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Prodrugs to the Rescue: The Discovery of a Potent eIF2B Activator Clinical Candidate"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Synthesis of Novel Bicyclic Azetidine Antimalarials"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Biosynthesis and Biotechnology Related to Natural Products
9:00 am - 9:30 am
"Biosynthesis of Unusual Molecules by Opportunistic Pathogens"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Discovery of New Natural Product from Fungi using Genome-Based Approaches"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Discovery and Engineering of Plant Natural Product Pathways"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Stereoselective Pyridoxal Radical Biocatalysis for Diversity-Oriented Synthesis"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Process Chemistry Toward Complex Bioactive Compounds
7:30 pm - 8:00 pm
"Development of a Commercial Manufacturing Process for Vepdegestrant, an Orally Bioavailable PROTAC Estrogen Receptor Degrader"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Pivoting to Catalysis for Kilo Scale API Deliveries"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Process Chemistry Toward Complex Bioactive Compounds"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Total Synthesis of Complex Natural Products
9:00 am - 9:30 am
"Synthetic Studies Toward Complex Natural Products"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Tactic Combinations for the Synthesis of Complex Natural Products with Important Biological Activities"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Computationally Augmented Total Synthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Primary and Secondary Metabolites as Inspiration for Synthesis"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Methods for Construction and Modification of Biologically Important Molecules
7:30 pm - 8:00 pm
"New Concepts for Atom and Functional Group Transfer"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"New Carbocyclization Reactions for the Synthesis of Complex Molecules"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"New Synthetic Methods Using Photochemistry"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Strategies and Tactics for Rapid Construction of Chemical Complexity
9:00 am - 9:30 am
"Exploring Ring Transformations: Opening, Formation, and Swapping of Cyclic Structures"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Creating Confined Spaces: Supramolecular Lewis Acid-Base Catalysis for Unlocking New Reactivities in Terpene Cyclizations"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Simplicity and Complexity: Photochemistry as an Enabling Tool"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Natural Product Synthesis With Designed Hydrocarbons"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Synthesis and Biosynthesis of Complex Natural Products
7:30 pm - 8:15 pm
"Genome Mining for New Chemistry"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"Discovery and Surprises with Natural Products"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure