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Neurobiology of Brain Disorders

Gordon Research Conference

Exploring Neurodegenerative Mechanisms Presents New Therapeutic Opportunities

August 4 - 9, 2024

Chairs

and

Vice Chairs

and

Rey Don Jaime Grand Hotel

Avinguda de l'Hotel

Castelldefels, Barcelona, Spain

Venue and Travel Information

Conference Description

The Neurobiology of Brain Disorders GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

The global challenge presented by neurodegenerative disorders is immense but the application of new molecular and cellular technologies is revealing important mechanistic insights. The temporal evolution of disease is being mapped at single-cell and tissue levels by multi-omic techniques. Key molecular interactions are being identified as drug targets and novel therapeutic approaches are being developed. These studies have highlighted disturbances in RNA metabolism, intracellular transport, proteostasis, inflammation and the role of aging. The 2024 Gordon Conference on Neurobiology of Brain Disorders will bring together research leaders from a wide range of disciplines to discuss their latest findings and how they might translate into new therapies. Invited speakers will be encouraged to present unpublished work and explore opportunities to collaborate. Junior scientists and graduate students are encouraged to submit abstracts for oral and poster presentations, and engage key opinion leaders in discussion. GRC conferences are famously informal and popular and they are always oversubscribed so early registration and abstract submission is advised.

Related Meeting

This GRC will be held in conjunction with the "Neurobiology of Brain Disorders" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Genetic Landscape of Neurodegenerative Disorders Discussion Leader:
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:50 pm	"The Genetic Landscape of Alzheimer's Disease and How This Informs Disease Mechanism"
8:50 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Recent Advances in Genetics and Genomic Approaches to Neurodegenerative Disease Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Deconstructing the Cellular Communities that Drive Trajectories to Alzheimer's Disease and Alternative Brain Aging"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Single Cell Dissection of Dementia Pathogenesis"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	"Integrative Functional Genomics in Post-Mortem Tissues from the ALS/FTD Disease Spectrum Identify New Biomarkers and Mechanisms for Patient Stratification"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	"Uncovering Mechanisms of Hyperexcitability in Neurodegenerative Disease with Functional Genomics"
10:30 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Regulation of LRRK2 Expression Links Parkinson's to Inflammation"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Epigenetic Signatures of Genetic Risk in Alzheimer's Disease"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Function and Neuroprotective Potential of Flcn Knockout in Parkinson’s Disease"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Regulation of Entorhinal Cortex Vulnerability by TENM3, a Genetic Susceptibility Factor for Alzheimer’s Disease"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizer:
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Contribution of Aging to Neurodegenerative Disease Discussion Leader:
6:00 pm - 6:20 pm	"Boosting Resilience to Prevent Neurodegeneration"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"Using Complex Genetics in Mice to Unlock the Secrets of Cognitive Resilience"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Age-Related Protein Turnover Aberrations Revealed by New Protein Tagging Models"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Role of Cellular Senescence in Brain Aging and Alzheimer’s Disease"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Contribution of Aging to Neurodegenerative Disease"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Frontotemporal Dementia and ALS Mechanistic Updates Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Role for ANXA11in the Regulation of Lysosome-Associated Local Translation in Neurons"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"TDP-43: Pathogenic Mechanism, Presymptomatic Fluid Biomarker and Therapeutic Strategy"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	"Elucidating Key Drivers of RNA Dysregulation in ALS Using a Novel Model of TDP43 Proteinopathy and ePRINT Technology"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	"TDP-43 Condensate Modulation Rescues TDP-43 Loss of Function in ALS Patient-Derived Motor Neurons and Mouse Models of TDP-43 Proteinopathy"
10:30 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"How DNA Research in All ALS Patients Will Change the Course of the Disease"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Aberrant Splicing Exonizes C9ORF72 Repeat Expansion in ALS/FTD"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"The ALS-FTD Cryptic Exon in UNC13A Mediates Synaptic Dysfunction Following Loss of TDP-43"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"What’s the FUS About?"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"ABC of TDP-43"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Parkinson’s Disease: Mechanistic Updates Discussion Leader:
6:00 pm - 6:20 pm	"Single Cell and Single Molecule Approaches to Map Early Mechanisms in Parkinson's Brain and Cell Models"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"Peripheral Immune Modulators in Body-First Parkinson’s Disease"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	"PINK1 Protein Biogenesis in Neurons Requires Integration of Signals from the ER and Endolysosomes to Enable Mitophagy"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:35 pm	"Utilizing Long-Read RNA Sequencing to Enhance Insight and Improve Therapeutic Targets for Neurodegenerative Disease-Linked Loci"
7:35 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Discovery of a Highly Selective, Orally Bioavailable, Brain-Penetrant LRRK2 Inhibitor"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Alzheimer’s Disease: Mechanistic Updates Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"In-Tissue Molecular Architecture in Alzheimer's Disease Post-mortem Brain"
9:25 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Cellular Mechanisms of Late-Onset Alzheimer’s Disease Risk Variants"
9:55 am - 10:05 am	Discussion
10:05 am - 10:15 am	"Molecular Cholinergic Deficits Drive Cortical Pathology in Presymptomatic Alzheimer’s Disease (PET Imaging)"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	"Brain Region-Specific Tau Hyperphosphorylation Mediates Alzheimer’s Disease-Associated Early-Onset Sleep Disruption"
10:30 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Role of APOE and the Innate and Adaptive Immune Response in the Setting of Amyloid and Tau Pathology"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Understanding Neuro-Glia-Immune Crosstalk at the Vulnerable Synapse"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Functional and Structural Impact of NLRP3 and NLRP1 Inflammasome Activation on Alzheimer Disease Pathogenesis"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Tauopathies: Mechanistic Updates Discussion Leader:
6:00 pm - 6:20 pm	"Uncovering Mechanisms of Tauopathy in Human iPSC Model"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"Mechanisms Controlling Cell Type-Selective Vulnerability to Tau Aggregation and Toxicity"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	"Tau Phosphorylation at Alzheimer’s Disease Biomarker Sites Impairs Tau Cleavage by Lysosomal Proteases"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"RNAi Knockdown of Microtubule-Associated Protein Tau as a Therapeutic Strategy for Tauopathies"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:40 pm	"Antisense Oligonucleotide Development for 4R Tau Mutations: Evaluating Phenotypic and Sleep Changes in Tauopathy Models"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"TRIM11 is a Novel E3 Ligase for Tau"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Biomarkers, Theranostics and Models Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:35 am	"Biomarkers in Neurodegenerative Diseases"
9:35 am - 9:50 am	Discussion
9:50 am - 10:10 am	"Ultrasound-Mediated Immunomodulation and Drug Delivery in Neurodegerative Disease"
10:10 am - 10:20 am	Discussion
10:20 am - 10:30 am	"[18F]Fluoroedaravone: a Positron Emission Tomography Probe for Imaging Oxidative Stress in the Central Nervous System"
10:30 am - 10:35 am	Discussion
10:35 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Modeling Age-Associated Neurodegeneration of Late-Onset Disorders via Direct Neuronal Reprogramming"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Mutation-Dependent Phenotype in Novel Human Tau KI Mouse Models"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Highly Sensitive Ligand-Binding Assay Confirms DOPA Decarboxylase in Plasma and Cerebrospinal Fluid as a Promising Biomarker Candidate for Parkinson's Disease"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Brain-Wide Engraftment of Human Monocytes, but Not Microglia, Induces a Chronic Proinflammatory State, Promoting Synaptic and Behavioral Dysfunction"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Development of a Comprehensive Cellular Platform to Study Lysosomal Dynamics for Neurodegenerative Disease Research"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Novel Therapeutic Approaches Discussion Leader:
6:00 pm - 6:20 pm	"The ALSpire Study: A Clinical Trial of an Antisense Oligonucleotide Targeting ATXN2 in Adults with ALS"
6:20 pm - 6:30 pm	Discussion
6:30 pm - 6:50 pm	"Targeting the ATXN2/STAU1 Complex in Cerebellar and Motor Neuron Degeneration"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:20 pm	"Advances in Splice-Correction Therapies for Spinal Muscular Atrophy"
7:20 pm - 7:30 pm	Discussion
7:30 pm - 7:50 pm	"Senescent Cells as a Therapeutic Target for Neurodegenerative Diseases"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institute On Aging of the National Institutes of Health under Award Number R13AG087665. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Neurobiology of Brain Disorders (GRS)

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