Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: How Tau Becomes Toxic
Discussion Leader: Steven Boggess (University of California, San Francisco, United States)
3:15 pm - 3:55 pm
Li Gan (Weill Cornell Medicine, United States)
"The Good, The Bad, and The Ugly: How Tau Becomes Toxic"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Mechanistic Advances in Understanding Brain Disorders
Discussion Leader: Ester Siantoputri (Rockefeller University, United States)
5:30 pm - 5:45 pm
Indigo Rose (University of California, San Francisco, United States)
"A Novel Strategy to Screen for Genetic Determinants of Selective Neuronal Susceptibility In Vivo"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Kitty Murphy (King's College London, United Kingdom)
"The APOE Isoforms Differentially Shape the Transcriptomic and Epigenomic Landscapes of Human Microglia in a Xenotransplantation Model of Alzheimer’s Disease"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Zena Chatila (Columbia University, United States)
"RNA- and ATAC-Sequencing Reveals a Unique CD83+ Microglial Population Focally Depleted in Parkinson’s Disease"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Alexandra Munch (Icahn School of Medicine at Mount Sinai, United States)
"Uncovering the Role of the MS4A Locus in Alzheimer’s Disease"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Aksinya Derevyanko (Salk Institute for Biological Studies, United States)
"Delivery of Chrdl1 to Target Synapse Loss in Alzheimer's Disease"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Leigh-Ana Rossitto (UC San Diego, United States)
"Dissecting the Molecular Mechanism of the Ketogenic Diet in Alzheimer's Disease"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Systems-Level Understanding of Neurodegeneration
Discussion Leader: Kate Onuska (Western University, Canada)
9:00 am - 9:15 am
Mathieu Bourdenx (University College London, United Kingdom)
"Cell-Type Specific Proteostasis Loss in Ageing"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Sumi Bez (UK Dementia Research Institute at UCL, United Kingdom)
"TRIM11 is a Novel E3 Ligase for Tau"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Martha Foiani (UK Dementia Research Institute at University College London, United Kingdom)
"Mutation-Dependent Phenotype in Novel Human Tau KI Mouse Models"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Thomas Goralski (Van Andel Institute, United States)
"Spatio-Temporal Dynamics of Lewy-Associated Molecular Dysfunction"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Pete Harley (University College London, United Kingdom)
"The ALS-FTD Cryptic Exon in UNC13A Mediates Synaptic Dysfunction Following Loss of TDP-43"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Victoria de los Angeles Soto Linan (CERVO Brain Research Center; Laval University, Canada)
"Novel Non-Invasive Retinal and Microbial Biomarkers for the Early Diagnosis of Parkinson’s Disease"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Role of APOE in Modulating the Innate and Adaptive Immune Response in Neurodegeneration
Discussion Leader: Nathasia Muwanigwa (University College London, United Kingdom)
1:30 pm - 1:45 pm
Camille Goldman (Icahn School of Medicine at Mount Sinai, United States)
"Investigating the Contribution of APOE4 on Disrupted Cholesterol Metabolism and A-Synuclein Pathology in a Stem-Cell-Derived Model of Human Brain Tissue"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:25 pm
David Holtzman (Washington University, United States)
"Role of APOE in Modulating the Innate and Adaptive Immune Response in Neurodegeneration"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes