Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Clinical and Pre-Clinical Successes and Failure Modes in Antibiotic Development
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:30 pm
"It is Hard to Predict, Especially About the Future, but There Will be a Future for Antibacterial Drugs"
8:30 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
"The Evolution and Consequences of the Plazomicin Development Program, the First Antibiotic Approved Under the “Tier B” Framework"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alternatives to Antibiotics
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Protection Against S. aureus Colonization by the Microbiome Antibiotic Lugdunin"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Developing Phage as 'Evolution-Proof' Therapies Against Antibiotic-Resistant Bacteria"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"SASPject: A Novel Antibacterial Protein Technology"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Collaborating with Innate Immunity to Treat Multidrug-Resistant Bacterial Pathogens"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Unraveling the Requirements for Drug Permeation and Target Engagement
The current state of approaches to address the challenges of bacterial uptake.
6:00 pm - 6:20 pm
"Identification of Novel Properties of Compounds for Optimization of Drug Permeation and Efflux Avoidance in Gram-Negative Bacteria"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Quantification of Antibiotic Accumulation and Activity in Gram-Negative Bacteria: Insights into Influx and Efflux Contributions and Drug Properties"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Revisiting Outer Membrane Permeability Mechanisms"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Scope, Limitations and Applications of the eNTRy Rules"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
New Approaches to Antibacterial Hits and Leads
9:00 am - 9:20 am
"Targeting Lipoprotein Biosynthesis in Gram-Negative Bacteria"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Novel Small-Molecule Inhibitors of Bacterial Lipoprotein Transport with Potent Antimicrobial Activity Against Enterobacteriaceae"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Inhibition of Bacterial Cell-Wall Biosynthesis by Carbohydrate Scaffolds Targeting the Glycosyltransferase Activity of Penicillin-Binding Proteins"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Approaches to Antibiotic Discovery in an Academic Environment"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Discovery and Microbiological Evaluation of Highly Potent Inhibitors of TrmD"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"The Application of Open Source Research to the Discovery and Development of New Antibiotics"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Advances in Enabling Diagnostics and PK/PD
The first half of this session will be on Enabling Diagnostics with two talks on recent progress on this subject. The second half of the session will consist of two talks on recent advances in PK/PD
6:00 pm - 6:20 pm
"Demystifying the Original Companion Diagnostic: AST, Its Intricacies, Challenges and Future"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Impact of Actionable Diagnostics of Infections on Patient Clinical Outcomes"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Developing Beta-Lactam/Beta-Lactamase inhibitor Combinations: Bacterial Kill and Resistance Emergence"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Pharmacodynamics: Limitations of the Standard Model and the Implications for Antimicrobial Drug Development"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Learning from Successes and Failures in Antibacterial Lead Optimization
9:00 am - 9:20 am
"Enhanced Lead Optimization Approach Leads to Novel Non-ß-Lactam PBP Inhibitors"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Tethered Peptide Macrocycles, a Novel Antibiotic Class Targeting Acinetobacter baumannii "
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"A Novel Class of Antibiotics Against Life-Threatening Gram-Negative Bacteria Targeting the Lipopolysaccharide Transport protein A"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Discovery of Xeruborbactam (QPX7728), an Ultra-Broad-Spectrum Boronic Acid Inhibitor of Serine and Metallo Beta-Lactamases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Using Probabilistic Approaches and AI/ML to Advance Antibacterial Drug Discovery Projects"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"A Systems Approach to Antibiotic Drug Discovery"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"A Genetic Platform to Study Bacterial Drug Efflux Pumps"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Octapeptins - Independent Antibiotic Agents or Antibiotic Adjuvants To Treat MDR/PmxR Gram-negative Bacteria"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Comparative Resistomics of Clinical and Experimental Antibiotics in Acinetobacter Baumannii"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
New Results from Clinical Studies
9:00 am - 9:30 am
"Next Generation BL/BLIs: Cefepime-taniborbactam and Ceftibuten-ledaborbactam"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Recarbrio (imipenem/cilastatin/relebactam): Updates from Surveillance and the Clinic"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Sulbactam-durlobactam, the First Pathogen-targeted Agent Developed for the Treatment of Multidrug-resistant Acinetobacter Infections"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Models for Advancing Antibiotics
6:00 pm - 6:35 pm
"AMR Action Fund: The Science Behind Our Investment Decisions"
6:35 pm - 7:00 pm
Discussion
7:00 pm - 7:35 pm
"CARB-X After 5 Years – Lessons Learned and Future Visions"
7:35 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure