Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Antibiotic Resistance and the Need for Novel Antibiotic Therapies
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Multi-Drug Resistant (MDR) Pathogens Are Driving the Need for New Novel Antibacterials"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"GARDP: Working Globally to Address the Antimicrobial Resistance Crisis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"How Heteroresistance Changes Our Understanding of Antibiotic Resistance"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Approaches to Antibiotic Discovery
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Reviving Natural Products Antibiotic Discovery"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Generative Artificial Intelligence for Antibiotic Discovery"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"AI for Antibiotic Discovery"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Challenges of Antibacterial Discovery"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Systems Chemical Biology Approach to Antibiotic Discovery"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Enabling Targeted Protein Degradation in Bacteria"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Targeted Based Approaches to Antibacterial Discovery
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Antibiotics Preorganized for Ribosomal Binding Overcome Antimicrobial Resistance"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Macrocyclic Peptides Disassemble the Periplasmic LPS Transport Bridge: New Approaches to Kill Multidrug-Resistant Gram-Negative Bacteria"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Cracking Nature’s Recipes to Design Lipid-Targeting Antibiotics"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"PBP2:MreC: An Ideal Target for New Antibacterial Agents"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Discovery Pipelines: Hits, Leads and Candidates
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Discovering Mechanistically Novel Antibacterial Leads through Phenotypic Screening"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Development of Broad-Spectrum MBL Inhibitors"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Engineering Broad Spectrum Novel Ribosome Inhibitors"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Attracting New Anti-Infective Candidates with Novel Targets Using the MAGNET Discovery Platform"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Achilles Heel of the Trojan Horse: Host Directed Therapy Against Mycobacterial Infections"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"The Guanidino Lipoglycopeptides: Semisynthetic Glycopeptides with Potent in Vitro and in Vivo Antibacterial Activity"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Bacterial Cell Envelope: Targets and Requirements for Drug Permeation
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"A New Antibiotic Traps Lipopolysaccharide in its Intermembrane Transporter"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"How Do Polymyxins Kill Bacteria?"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Measuring the Interactions of Polymyxins with the Gram-Negative Outer Membrane"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Guidelines for Compound Accumulation in Pseudomonas Aeruginosa Enable Antibiotic Development"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Advances in Antibiotic Combination Therapy
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Beta-Lactamases and Skaters: Pairs and Singles"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Mechanistic Insights and Therapeutic Strategies for Targeting the Most Synergistic Penicillin-Binding Proteins Across Three Gram-Negative ‘Superbugs’"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Discovery of Enmetazobactam"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Mycobacterium Abscessus: The Promise of Dual ß-Lactams Therapy"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"How to Give Bacteria Food Poisoning: Antibiotics that Hijack Nutrient Transporters"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Applying Concepts on Antibiotic-Induced Bacterial Death to Rationally Combine Drugs for Treatment of Mycobacterium Abscessus Lung Disease"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unconventional Antibiotics: Phage Therapy and Anti-Infectives
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Biasing Bacteriophage Behaviours"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Antisense Antibiotics as Precision Therapeutics for Pseudomonas Aeruginosa"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Development of Efflux Pump Inhibitors for Overcoming Antimicrobial Resistance in Enterobacterales Infections"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Chemical Inhibition of Staphylococcus Aureus Virulence with a Plant-Derived Natural Product"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Moving the Needle for Difficult-to-Eradicate Infections
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Addressing Antimicrobial Resistance in Clostridioides difficile : Clinical Implications and the Motivation for Novel Treatment Approaches"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"A Six Decade Wait for a Novel Broad-Spectrum Antibacterial Drug Class: Development of BWC0977"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Redesign of Rifamycins for the Treatment of Mycobacterium Abscesuss Lung Disease"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Apramycin, a Promising Candidate in the Treatment of Chronic NTM Infections"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Omadacycline as a Potential New Option for NTM Pulmonary Disease Caused by M. Abscessus "
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Learning from Failures and Moving to Success in Clinical Trials
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Experiences and Learnings through Developing a Novel Antibiotic, Zosurabalpin"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Clinical Data on a Phage Trial"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
"Integrating Global Needs and R&D Activities to Solve the Antibiotic Resistance Crisis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure