Session 1 - February 2, Sunday pm
CHEMISTRY AND BIOLOGY OF NITRIC OXIDE: OVERVIEWS
Chair & Discussion Leader: Louis J. Ignarro (Los Angeles)
- 7:30-7:40 - Welcome and Introduction
- 7:40-8:15 - Jean Le Gall (Athens) - "Nitric oxide in non-mammalian systems"
- 8:25-9:00 - Owen W. Griffith (Milwaukee) - " Mammalian nitric oxide biology: overview of enzymology and pharmacology"
- 9:10-9:50 - General Discussion
Session 2 - February 3, Monday am
BIOSYNTHESIS OF NITRIC OXIDE
Chair & Discussion Leader: Owen W. Griffith (Milwaukee)
- 9:00-9:35 - Dennis J. Stuehr (Cleveland) - "New aspects of NO synthase structure and mechanism"
- 9:45-10:20 - John Salerno (Troy) - "Domain structure and control elements of constitutive NO synthase"
- 11:00-11:35 - Bettie Sue Masters (San Antonio) - "Comparative structure/function studies of three isoforms of E.coli expressed NO synthase"
- 11:45-12:25 - General Discussion
Session 3 - February 3, Monday pm
REGULATION OF NITRIC OXIDE PRODUCTION
Chair & Discussion Leader: Ulrich Förstermann (Mainz)
- 7:30-8:05 - Steven S. Gross (New York) - "Calmodulin and the autoinhibitory domain of constitutive NO synthase"
- 8:15-8:40 - Thomas Michel (Boston) - "Tissue-specific regulation of endothelial NO synthase"
- 8:50-9:25 - Ellen I. Closs (Mainz) - "Arginine supply of NO syntheses in cells expressing different NO synthase isoforms"
- 9:35-10:15 - General Discussion
Session 4 - February 4,Tuesday am
MOLECULAR MECHANISMS OF NITRIC OXIDE CYTOXICITY
Chair & Discussion Leader: Matthew B. Grisham (Shreveport)
- 9:00-9:35 - David A. Wink (Bethesda) - "Chemical biology of nitric oxide: intermediates in NO metabolism related to cytotoxicity"
- 9:45-10:20 - Joseph Beckman (Birmingham) - "Targets of peroxynitrite in vivo"
- 11:00-11:35 - Helmut Sies (Dusseldorf) - "Defense against peroxynitrite"
- 11:45-12:25 - General Discussion
Session 5 - February 4, Tuesday pm
OXIDATIVE STRESS AND NITRIC OXIDE
Chair & Discussion Leader: Jonathan S. Stamler (Durham)
- 7:30-8:05 - Michael S. Wolin (Valhalla) - "Influence of nitric oxide-oxidant interactions on cellular signaling mechanisms"
- 8:15-8:40 - Bruce Demple (Boston) - "Stress gene induction by nitric oxide"
- 8:50-9:25 - Matthew B. Grisham (Shreveport) - "Role of reactive metabolites of oxygen and nitrogen in chronic inflammation"
- 9:35-10:15 - General Discussion
Session 6 - February 5,Wednesday am
BACTERIAL NITRIC OXIDE METABOLISM: ECOLOGICAL ASPECTS
Chair & Discussion Leader: William J. Payne (Athens)
- 9:00-9:35 - James S. Shapleigh (Ithaca) - "Regulation of the nitrogen cycle by nitric oxide"
- 9:45-10:20 - Ralf Conrad (Marburg) - "Production and consumption of nitric oxide in soils"
- 11:00-11:35 - Nigel Benjamin (London) - "Nitric oxide synthesis in man from bacterial and chemical nitrate reduction"
- 11:45-12:25 - General Discussion
Session 7 - February 5, Wednesday pm
KEY-NOTE LECTURE
- 7:30-8:10 - BUSINESS MEETING
- 8:10-9:10 - Carl F. Nathan (New York) - "Nitric Oxide in Host Defense"
- 9:10-9:40 - General Discussion
Session 8 - February 6, Thursday am
SIGNAL TRANSDUCllON MECHANISMS AND NITRIC OXIDE
Chair & Discussion Leader: Jack R. Lancaster, Jr. (New Orleans)
- 9:00-9:35 - Judith N. Burstyn (Madison) - "Regulation of activity in soluble guanylyl cyclase"
- 9:45-10:20 - John Garthwaite (London) - "The nitric oxide-cyclic GMP signaling pathway in the central nervous system"
- 11:00-11:35 - Jonathan Stamler (Durham) - "Redox signaling: new insights and proteins"
- 11:45-12:25 - General Discussion
Session 9 - February 6, Thursday pm
BACTERIAL AND FUNGAL NITRIC OXIDE METABOLISM
Chair & Discussion Leader: Walter G. Zumpft (Karlsruhe)
- 7:30-8:05 - Rob J. M Van Spanning (Amsterdam) - "Control of denitrification in Paracoccus denitrificans"
- 8:15-8:40 - Hirofumi Shoun - Recent data on the fungal denitrifying system
- 8:50-9:25 - Myles R. Cheesman (Norwich) - "The bacterial nitric oxide reductase"
- 9:35-10:15 - General Discussion
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