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Nitric Oxide

Gordon Research Conference

May 22 - 27, 2005
Chair
Vice Chair
Renaissance Tuscany Il Ciocco
Via Giovanni Pascoli
Lucca (Barga), Lucca, Italy
 Venue and Travel Information

Conference Description

The Gordon Research Conference on Nitric Oxide (NOGRC) was established in 1995. It meets every two years to discuss frontier topics in NO chemistry, biochemistry, and biology, with an eye toward molecular mechanisms. The 2005 NOGRC will be in Il Ciocco, Barga, Italy, on May 22-27. Because this is the first time our NOGRC will be held in Europe, it presents a great opportunity to get together with our European colleagues in a particularly beautiful part of the world (Tuscany). Invited speakers are encouraged to present their most recent findings and there will be ample discussion time scheduled after each talk. New works are also to be featured in a hot topics session and in two prominently featured poster sessions.

Conference Program

SUNDAY
2:00 pm - 9:00 pmArrival and check-in
6:00 pm Dinner
7:30 pm - 9:30 pmWIDE WORLD OF NO BIOLOGY
Discussion Leader: Steven Gross (Weill College Cornell Univ. USA)
7:30 pm - 7:45 pmDennis Stuehr (Cleveland Clinic, USA)
"Welcome and Introductory Remarks"
7:45 pm - 8:15 pmMichael Espey (NCI, USA)
"Flashy science: Nitrogen dioxide and the enlightened Firefly"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:55 pmDavid Whitlock (Nitroceutic, USA)
“Commensal nitrifying bacteria: A source for basal NO in mammals?”
8:55 pm - 9:05 pmDiscussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMETALS IN PROCESSING, TRANSPORT, AND STORAGE OF NO
Discussion Leader: Steve Chapman (Univ of Edinburgh, UK)
9:00 am - 9:25 amRobert Poole (University of Sheffield, UK)
"Bacterial defences against NO and nitrosative stresses - insights from physiology and genome-wide profiling"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amAnn Walker (University of Arizona, USA)
"Structure-function aspects of a new class of nitrophorins"
10:05 am - 10:20 amDiscussion
10:20 am - 11:10 amGroup Photo / Coffee Break
11:10 am - 11:35 amGiorgio Ricci (Univ of Rome, Italy)
"Glutathione transferases and NO metabolism"
11:35 am - 11:50 amDiscussion
11:50 am - 12:15 pmToru Shimizu (Tohoku University, Japan)
"NO activation of a heme-regulated kinase: A paradigm for PAS protein interactions with NO?"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmPASSING THE NO AROUND: MECHANISMS AND REGULATION
Discussion Leader: David Wink (NCI, USA)
5:30 pm - 5:50 pmJack Lancaster (University of Alabama Birmingham, USA)
"Nitroxidation, Nitrosation, Nitrosylation, and Nitration: In Silico Predictions of In Vivo Nitrogen Oxide Chemistry"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmMartin Feelisch (Boston University, USA)
"Presence and dynamics of RSNO, RNNO, and heme-NO species in vivo"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmBill Montfort (University of Arizona, USA)
"Structure and stability in protein S-nitrosation"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmMark Gladwin (NIH, USA)
“Unraveling the reactions of nitrite and hemoglobin in human physiology and therapeutics”
7:20 pm - 7:30 pmDiscussion
8:00 pm Dinner
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNO AND MITOCHONDRIA
Discussion Leader: Volker Ullrich (University of Konstanz, Germany)
9:00 am - 9:30 amPeter Rich (University College London, UK)
"Update on the mitochondrial electron transport chain"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amVictor Darley Usmar (Univ Alabama Birmingham, USA)
"The Mitochondrial NO-cytochrome c oxidase signaling pathway; mechanisms and biological implications"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:05 amChris Cooper (Univ of Essex, UK)
"Mechanisms of NO and peroxynitrite interaction with mitochondrial cytochrome c oxidase"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 am Kulwant Aulak (Cleveland Clinic)
"Dynamic and reversible protein nitration in mitochondria"
11:40 am - 11:50 amDiscussion
11:50 am - 12:15 pmEnzo Nisoli (Univ of Milan, Italy)
"NO in mitochondrial biogenesis"
12:15 pm - 12:25 pmDiscussion
12:30 pm Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmCELL BIOLOGY OF NO
Discussion Leader: Ferid Murad (University of Texas Houston)
5:30 pm - 5:50 pmDavid Fulton (Medical College of Georgia, USA)
"Localization of eNOS determines its mechanism of activation"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmTim Billiar (Univ. Pittsburgh, USA)
“NO, stem cells, and cardiomyogenesis”
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmLimin Liu (UCSF, USA)
"Essential role of GSNO reductase in regulating nitrosothiol homeostasis in vivo"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmGerald Ramaeu (New York University, USA)
"Specificity and dynamics of nNOS phosphorylation within freshly isolated neuronal cells"
7:20 pm - 7:30 pmDiscussion
8:00 pm Dinner
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNO SYNTHASE ENZYMOLOGY
Discussion Leader: Bettie Sue Masters (University of Texas San Antonio, USA)
9:00 am - 9:25 amNigel Scrutton (Univ of Leicester, UK)
"Protein dynamics and subdomain movements in the electron transfer reactions of flavoproteins"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 am Andrew Munro (Univ of Leicester, UK)
"The NO synthase flavoprotein: Comparison and contrast with other dual flavin reductases"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amSimon Daff (Univ of Edinburgh, UK)
"Protein elements that tune oxygen activation by the NO synthase heme"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amBrian Crane (Cornell Univ USA)
"Bacterial NO synthase-like proteins: Novel functions and mechanisms"
11:40 am - 11:50 amDiscussion
11:50 am - 12:15 amDavid Wendehenne (University of Bourgogne, France)
“NO synthesis and signaling in plant cells”
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II
5:30 pm - 6:45 pmHOT TOPICS FROM YOUNG INVESTIGATORS
Discussion Leader: Bernd Mayer (Univ of Graz, Austria)
6:45 pm - 7:30 pmKEYNOTE TALK
Steven Tannenbaum (MIT, USA)
"Genesis of the NO field from a novel perspective"
7:30 pm - 8:00 pmBusiness Meeting
8:00 pm Dinner
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCENTRAL ROLES OF ARGININE
Discussion Leader: Lou Ignarro (UCLA, USA)
9:00 am - 9:25 amSid Morris (University of Pittsburgh, USA)
"Enzyme systems that regulate Arginine availability"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amDavid Ash (Temple University USA)
“Structure, mechanism, and inhibition of the arginases”
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amSerpil Erzurum (Cleveland Clinic, USA)
"Altered Arginine processing underlies fundamental cellular changes seen in pulmonary hypertension"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amClaudia Morris (Childrens Hospital Oakland, USA)
“Role of Arginine Depletion in Asthma”
11:40 am - 11:50 amDiscussion
11:50 am - 12:15 pmPatrick Vallance (University College London, UK)
"Arginine demethylase enzymes: Structure, function, and clinical relevance"
12:15 pm - 12:25 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session II
5:30 pm - 7:30 pmCONTROLLING DELIVERY OF NO AND RELATED SPECIES
Discussion Leader: Richard Knowles (Glaxo-Wellcome, UK)
5:30 pm - 5:55 pmAlan Wallace (Astra-Zeneca, UK)
"Pharmacology of specific NOS inhibitors and the structural basis for their selectivity"
5:55 pm - 6:10 pmDiscussion
6:10 pm - 6:35 pmStefano Fiorucci (Univ. of Perugia & Nicox, Italy)
"Development and utility of NO-donating anti-inflammatory drugs"
6:35 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pm Katrina Miranda (University of Arizona, USA)
"Rational design of nitroxyl-donors"
7:15 pm - 7:30 pmDiscussion
8:00 pm Dinner
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 am Departure

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