Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Physiological NO Signaling
Discussion Leader: Serpil Erzurum (The Cleveland Clinic Foundation , USA)
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:55 pm
Joseph Loscalzo (Harvard Medical School, USA)
"Vascular
Redox State Regulation and Nitric Oxide"
8:55 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Canonical and Non-Canonical Signaling Through sGC
Discussion Leaders: Elsa Garcin (University of Maryland, Baltimore County, USA) and Miriam Cortese-Krott (Heinrich Heine University Dusseldorf, Germany)
9:00 am - 9:20 am
Greg Thatcher (College of Pharmacy, University of Illinois at Chicago, USA)
"NO Memory Is a Good Memory, Except When It's a Headache"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Adam Straub (University of Pittsburgh, USA)
"Cyb5R3 and cGMP Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Arnab Ghosh (Cleveland Clinic, USA)
"Soluble Guanylate Cyclase Dysfuction in Asthma"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Jessica Wales (University of Arizona, USA)
"Discovery of a Conserved Stimulator Binding Site in the β1 H-NOX Domain of Soluble Guanylate Cyclase"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
Annie Beuve (New Jersey Medical School, Rutgers University, USA)
"A Well-Connected NO-Guanylyl Cyclase in the Cardiovascular System"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Emmanuel Buys (Harvard Medical School, USA)
"Targeting
NO-Signaling: A Novel Therapeutic Approach for Glaucoma"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Katrina Miranda (University of Arizona, USA)
"Nitroxyl Signaling"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
NO, Mitochondria and Metabolic Syndrome
Discussion Leaders: Victor Darley-Usmar (University of Alabama at Birmingham, USA) and Martin Feelisch (University of Southampton, United Kingdom)
7:30 pm - 7:50 pm
Jane Reusch (University of Colorado Denver, USA)
"Deconstructing the Exercise Impairments in Diabetes:
Molecular Targeting of NOS for Reconstruction"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jason Allen (Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Australia)
"Nitrate Supplementation as an Ergogenic Aid in Cardiovascular Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Brad Hill (University of Louisville, USA)
"Endothelial NOS in Obesity and Exercise"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Bryndon Oleson (Medical College of Wisconsin, USA)
"Nitric Oxide Says 'NO' to DNA Damage-Dependent
Apoptosis in β-cells"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
NO Signaling via Post-Translational Modifications
Discussion Leaders: Andrew Gow (Rutgers University, USA) and Rakesh Patel (University of Alabama at Birmingham, USA)
9:00 am - 9:20 am
Lisa Palmer (University of Virginia, USA)
"S-Nitrosylation and the Regulation of Intracellular Transport: Implications for Gender Difference in the Development of Pulmonary Arterial Hypertension"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Paschalis-Thomas Doulias (Children's Hospital of Philadelphia, USA)
"Regulation
of Mitochondrial Fatty Acid Oxidation by Nitric Oxide. Mechanistic Insights
and Therapeutic Interventions"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Mark Kohr (Johns Hopkins Bloomberg School of Public Health, USA)
"S-Nitrosation and Ischemia-Reperfusion Injury: New Insights from the Female Heart"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Tara Deboer (University of California, Berkeley, USA)
"Peroxynitrite-Generating Platforms and Resulting Post-Translational Modifications"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
Joshua Hare (University of Miami, USA)
"Regulation of S-Nitrosation in the Cardiovascular System"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Jennifer Van Eyk (Cedars-Sinai Medical Center, USA)
"NO and Arginine Based Post-Translational Modifications of the Heart"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Francisco Schopfer (University of Pittsburgh, USA)
"Reactions of Nitrated Fatty Acids: Formation, Conjugation and Degradation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Taking the NO Pathway to the Clinic: Current Clinical Trials
Discussion Leader: Timothy Billiar (University of Pittsburgh, USA)
7:30 pm - 7:50 pm
Mark Gladwin (University of Pittsburgh, USA)
"Taking Nitrite to the Clinic"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Todd Milne (Ironwood Pharmaceuticals, USA)
"Application
of sGC Stimulators to Human Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
David Rodman (Nivalis Therapeutics, Inc., USA)
"GSNO Reductase Inhibitors in the Clinic"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Diane Jorkasky (Complexa, Inc., USA)
"Development of Nitrolipids for the Clinic"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
NO Production and Crosstalk with Other Gasotransmitters
Discussion Leaders: Christopher Kevil (Louisiana State University, USA) and Peter Ford (University of California, Santa Barbara, USA)
9:00 am - 9:20 am
John Calvert (Emory University, USA)
"Regulation of Cardiac Mitochondria by Hydrogen Sulfide"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jon Fukuto (Sonoma State University, USA)
"Interaction and Crosstalk Between Hydrogen
Sulfide and Nitrogen Oxide Species"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Bindu Paul (Johns Hopkins School of Medicine, USA)
"Gasotransmitter Signaling
in Neurodegenerative States"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Megan Frost (Michigan Technological University, USA)
"Toward a Better Understanding of Targeted Dose and Duration of NO Needed and the Development of Controlled NO Delivery Materials"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Hiroshi Takagi (Graduate School of Biological Sciences, Nara Institute of Science and Technology, Japan)
"Synthetic Mechanism and Physiological Role of Nitric Oxide in Yeast"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Dominic Paari (LSU Health Sciences Center Shreveport, USA)
"Role of NO and H2 S in the Pathogenesis of Atrial Fibrillation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Takaaki Akaike (Tohoku University Graduate School of Medicine, Japan)
"Persuflide Regulation of Mitochondrial Number and Function"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
NO Modulation of Cancer Progression
Discussion Leaders: Katrina Miranda (University of Arizona, USA) and David Wink (National Cancer Institute, NIH, USA)
7:30 pm - 7:50 pm
Debashree Basudhar (National Cancer Institute, NIH, USA)
"Cross Talk Between Inflammation Associated
Proteins NOS2 and COX2
as a Driver of Breast Cancer Progression in Tumor
Microenvironment"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jenny Chang (Houston Methodist Cancer Center at Texas Medical Center, USA)
"Targeting
iNOS in Cancer"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Sharon Glynn (National University of Ireland Galway, Ireland)
"Is There a Role for Nitric Oxide in Prostate Carcinogenesis?"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Douglas Thomas (University of Illinois at Chicago, USA)
"Nitric Oxide Is an Epigenetic Driver of Cancer"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Paradigms of NO-Dependent Cardiovascular Signaling
Discussion Leaders: Amrita Ahluwalia (Queen Mary University of London, United Kingdom) and William Montfort (University of Arizona, USA)
9:00 am - 9:20 am
Ye Chen-Izu (University of California, Davis, USA)
"NO Mediates Mechano-Chemo-Transduction During Cardiac Myocyte Contraction"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Annarita Di Lorenzo (Weill Cornell Medicine, USA)
"Nogo-B Regulates S1P/S1PR1/NO Pathway to Impact Cardiovascular Functions"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
Nathan Bryan (Baylor College of Medicine, USA)
"Nitrite, the Microbiome and Blood Pressure"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Jose Tanus-Santos (University of Sao Paulo, Brazil)
"Evidence Supporting S-Nitrosothiols Formation as a Possible Mechanism Involved in the Blood Pressure Effects of Oral Nitrite"
10:35 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
Christine Helms (University of Richmond, USA)
"The In Vitro Effect of Fibrin Modification Due to NO Exposure"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Paola Corti (University of Pittsburgh, USA)
"Globin X Is a Nitrite Reductase"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Dan Jones (William Harvey Research Institute, Queen Mary University of London, United Kingdom)
"Nitrite and Inflammatory Signaling in Acute Myocardial Infarction"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Biochemical NO Signaling Mechanisms
Discussion Leader: Neil Hogg (Medical College of Wisconsin, USA)
7:30 pm - 8:30 pm
Rafael Radi (University of the Republic, Uruguay)
"Nitric Oxide, Peroxynitrite and Protein Tyrosine Nitration: Facts, Unknown and Challenges"
8:30 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure