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Nitric Oxide

Gordon Research Conference

Molecular Mechanisms of Nitric Oxide Signaling in Health and Disease

February 12 - 17, 2023

Chair

Vice Chair

Ventura Beach Marriott

2055 Harbor Boulevard

Ventura, California, United States

Venue and Travel Information

Conference Description

The Nitric Oxide GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

In this first Nitric Oxide focused meeting since the pandemic we will focus on the role that NO plays both in health and disease. Furthermore, we will examine the molecular mechanisms that regulate these functions. Topics will range from the role of NO in pulmonary function and COVID itself to optimal function with tissues such as skeletal muscle. Our goal is to create a diverse atmosphere and vibrant discussion that will lead to advances in the field and encourage the development of young and old scientists alike in the field of nitric oxide biology and chemistry.

Related Meeting

This GRC will be held in conjunction with the "Nitric Oxide" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Heme and Nitric Oxide Discussion Leader:
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:45 pm	"From Heme to Nitric Oxide and Back Again: Remarkable Relationships and Their Astounding Consequences"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	"Heme P460: It's NO P450"
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cardiovascular Function: The Role of Nitric Oxide in Physical Performance and Health Discussion Leaders: and
9:00 am - 9:20 am	"Nitric Oxide Effect? The Intra- and Interindividual Variability in the Response to Dietary Nitrate Supplementation"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Changes in Nitric Oxide Metabolism with Exercise Training: Do We Really Need More at Skeletal Muscle Level?"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Bridging the Gap: Translation of Nitric Oxide Discoveries Into Clinical Medicine"
10:50 am - 11:00 am	Discussion
11:00 am - 11:15 am	"Human Arterial Vasoreactivity is Modulated by Variation in The Abundance and Structure of Endothelial Hemoglobin"
11:15 am - 11:20 am	Discussion
11:20 am - 11:35 am	"Natural mutations of human XDH promote the nitrite-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"A nitrodilator-activated intracellular NO store (NANOS) important for cardiovascular health"
11:50 am - 11:55 am	Discussion
11:55 am - 12:00 pm	General Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cysteine Modification Discussion Leaders: and
7:30 pm - 7:55 pm	"S-nitrosocysteine and Respiratory Control"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"Protein S-Nitrosylation: From Methodology to Biology and Function"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 8:55 pm	"Nrf2 as a Regulator of Mitochondrial Activity, NO Signaling and Sulfur Metabolism"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:15 pm	"Regulation of GABAergic Synapses by Gephyrin S-Nitrosylation"
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Sources of Nitric Oxide Bioactivity and The Role of Redox in Their Regulation Discussion Leaders: and
9:00 am - 9:20 am	"Red Blood Cells from eNOS-Deficient Mice and Patients with Preeclampsia Induce Endothelial Dysfunction via Oxidative Stress and Abnormal Arginase Function"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Nitric Oxide Synthases, a New Family of NADPH-Dependent Sulfur Oxidoreductases"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Redox Regulation of sGC by CYB5R3"
10:50 am - 11:00 am	Discussion
11:00 am - 11:15 am	"Nitric Oxide Metabolism in the Eye: the Importance of Nitrate Reduction Pathways"
11:15 am - 11:20 am	Discussion
11:20 am - 11:35 am	"Epigenetic Alterations Induced by Reactive Nitrogen and Sulfur Species"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Thiol Facilitated Reductive Nitrosylation of Free Heme in a Membrane System"
11:50 am - 11:55 am	Discussion
11:55 am - 12:00 pm	General Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Signaling Mechanisms of Nitric Oxide and Other Oxidants Discussion Leaders: and
7:30 pm - 7:50 pm	"The Redox Physiology of Red Blood Cells: Lessons from Erythroid Cell-Specific Knock-out and Knock-in Mice"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Nitrite and Persulfides in Cardiovascular Regulation"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"Soluble Guanylyl Cyclase Uses Thioredoxin as a Nitrosothiol Relay: A Marriage of Reason?"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:00 pm	"Thiol Facilitated Reductive Nitrosylation Reaction of Nitric Oxide and Ferric Heme Form A Labile Iron-Nitrosyl-Heme and Thiyl Radical"
9:00 pm - 9:05 pm	Discussion
9:05 pm - 9:15 pm	"S-Nitrosocysteine Behaves as a Hypoxia-Mimetic, cGMP-Independent Ligand, Signaling Through Kvß2"
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	The Role of Nitric Oxide in Pregnancy and Development Discussion Leaders: and
9:00 am - 9:20 am	"Role of S-nitrosylation and S-nitrosogluathione Reductase (GSNOR) in Mouse and Human Pregnancy."
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Uterine Vascular Reliance on Nitric Oxide During Pregnancy"
9:50 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Mechanisms of Placental Dysfunction"
10:50 am - 11:00 am	Discussion
11:00 am - 11:15 am	"Cytoglobin Regulates Nitric Oxide-Dependent Cilia Motility and Organ Laterality in Development"
11:15 am - 11:20 am	Discussion
11:20 am - 11:35 am	"Connexin 43 Hemichannels and Calcium Entry in Arterial Relaxation in Female Mice"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Lysine Acetylation in human MnSOD May Rotect From Tyrosine-34 Nitration and Enzyme Inactivation"
11:50 am - 11:55 am	Discussion
11:55 am - 12:00 pm	General Discussion
12:00 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Immunometabolism and Cellular Phenotype Discussion Leaders: and
7:30 pm - 7:55 pm	"Regulation of Macrophage-derived Itaconate by Nitric Oxide: Insights from Cell and Mouse Models of BH4 and NO Deficiency"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"Nitric Oxide in Macrophage Immunometabolism: Evidence for HNO-mediated Inhibition of Pyruvate Dehydrogenase"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:05 pm	"Dissecting The Synergistic Effects of Nitric Oxide Synthase and PI3K Inhibitors in Metaplastic Breast Cancer"
9:05 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Cardiopulmonary Effects of Nitric Oxide Discussion Leaders: and
9:00 am - 9:20 am	"High Dose Inhaled Nitric Oxide: A Very Preliminary Clinical Experience"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Nitro-fatty Acid Regulation of Host and Microbial Signaling in Obesity-Associated Asthma"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	"S-Nitrosoglutathione Reductase: A New Target for Therapeutic Development in Bronchopulmonary Dysplasia"
10:10 am - 10:15 am	Discussion
10:15 am - 10:40 am	Coffee Break
10:40 am - 11:00 am	"Asthma and Nitric Oxide and Inflammation with Arginine Metabolism"
11:00 am - 11:10 am	Discussion
11:10 am - 11:20 am	"Impact of Low NO level on Globin Maturation and Functional Significance of Hemoglobin Resident in The Lung Epithelium"
11:20 am - 11:25 am	Discussion
11:25 am - 11:35 am	"Oxygen Responsive Metabolic Regulation In Red Blood Cells Via ENOS Based S-nitrosylation Signaling"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Chronic anemia aggravates the systemic endothelial dysfunction in acute myocardial infarction"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Dimethyl Malonate Preserves Kidney and Mitochondrial Function in A Mouse Model of Acute Kidney Injury"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	"Erythroid Specific Knock Out of Soluble Guanylyl Cyclase Leads to Disrupted Erythropoiesis, Anemia and Splenomegaly in Mice"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Nitric Oxide Signaling in Vascular Health Discussion Leader:
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:20 pm	"Red cells, Hypoxia and Cardioprotection"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 9:10 pm	"Emerging Roles for Alpha Globin in the Cardiovascular System"
9:10 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R13HL167550. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health

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Conference History Nitric Oxide (GRS)

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