Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Notch Signaling in Biology
Discussion Leader: Pamela Stanley (Albert Einstein College of Medicine, United States)
7:40 pm - 8:20 pm
Spyros Artavanis-Tsakonas (Harvard, United States)
"Notch Signaling: A Paradigm of Biological Complexity"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Ellen Rothenberg (California Institute of Technology, United States)
"Impacts of Notch Signaling on a Multipotent Progenitor-Cell Gene Regulatory Network to Initiate T Cell Development"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Structure and Mechanisms of Notch Activation and Modulation
Discussion Leader: Stephen Blacklow (Harvard Medical School, United States)
9:00 am - 9:20 am
Julia Rogers (Harvard Medical School, United States)
"Notch Induces Transcription by Stimulating Release of Paused RNA Pol II Without Increasing Chromatin Accessibility"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Hideyuki Takeuchi (University of Shizuoka School of Pharmaceutical Sciences, Japan)
"Significance of Site-Specific Xylosyl-Elongation of O-Glucose Glycans in Notch Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Natalia Babilonia-Díaz (University of Minnesota, United States)
"Development of Notch Agonists through Protein Engineering and Multivalent Scaffolds"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Oren Gozlan (Tel Aviv University, Israel)
"Neuralized-Like Proteins Differentially Activate Notch Ligands"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Pamela Stanley (Albert Einstein College of Medicine, United States)
"Regulation of Notch Signaling by O-Glycans in Intestinal and Immune Cell Development"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Vincent Luca (Moffitt Cancer Center & Research Institute, United States)
""Snags" in the Development of Targeted Notch Signaling Modulators"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Luisa Iruela-Arispe (Northwestern University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Notch, Cancer, and Therapeutics
Discussion Leader: Jon Aster (Brigham and Women's Hospital, United States)
7:30 pm - 7:50 pm
Ivan Maillard (University of Pennsylvania, United States)
"A Critical Role of Notch Signaling in the Immune Response to SARS-CoV-2 mRNA Vaccination"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Freddy Radtke (École Polytechnique Fédérale de Lausanne, Switzerland)
"Notch: Cell Plasticity and Therapeutic Escape in Triple Negative Breast Cancer"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Rumela Chakrabarti (University of Miami, United States)
"Notch-Hippo Signaling Increases Cholesterol Metabolism in Tumor Associated Macrophages Promoting Resistance to Therapy in Breast Cancer"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Min Guo (University Medical Center Ulm, Germany)
"A Non-Coding Mutation Within the NOTCH1 Gene Overrides Tumor Suppressor Activity in Chronic Lymphocytic Leukemia (CLL)"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Simona Hankeova (Genentech, United States)
"Developing Synthetic Notch Agonists to Control Cell Fate Switches and Understand Receptor Activation Mechanisms"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Bingqing Zou (The Methodist Hospital Research Institute, United States)
"Targeting JAG1 Overcomes Pancreatic Cancer Immunotherapy Resistance by Reinvigorating cDC1 and CD8 T cells"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Notch, Development, and Homeostasis
Discussion Leader: Sarah Bray (University of Cambridge, United Kingdom)
9:00 am - 9:20 am
Hamed Jafar-Nejad (Baylor College of Medicine, United States)
"Towards an AAV-Based Therapeutic Strategy for Alagille Syndrome"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Nadean Brown (University of California, Davis, United States)
"Multiple Roles for Notch Signaling in the Prenatal Mouse Eye"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Stacey Huppert (Cincinnati Children's Hospital Medical Center, United States)
"Notch-Driven Hepatocyte Plasticity Reveals Undiscovered Liver Temporal Reprogramming Competency"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Lenka Belicova (Karolinska Institutet, Sweden)
"Studying Regulation of Intrahepatic Bile Duct Development by Notch Signaling Using Advanced Imaging and in Utero Gene Expression Manipulation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Lluc Mosteiro (Genentech, United States)
"Notch is Essential for Adult Thyroid Function Through Maintaining Proper Mitochondrial Activity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Brian Gebelein (Cincinnati Children's Research Foundation, United States)
"Defective Notch Signaling in Endothelial Cells is a Primary Driver of Pathogenesis in a Mouse Model of Adams Oliver Syndrome"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Kenji Matsuno (The University of Osaka, Japan)
"Macrophages Carrying Pecanex Mutation Secrete an Inhibitor that Suppresses Notch Signaling During Lateral Inhibition"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Tzumin Lee (University of Michigan, United States)
"Dynamic Notch Diversifies Newborn Neurons Serially Made by a Common Fly Neural Stem Cell"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Late-Breaking Topics in Notch Biology
Discussion Leader: Robert Faryabi (University of Pennsylvania, United States)
7:30 pm - 7:40 pm
Bushra Raj (University of Pennsylvania, United States)
"Tracing Notch Activity with CRISPR Barcode Recorders"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Rubul Mout (Boston Children's Hospital, United States)
"Design of a Soluble Multivalent Notch Agonist for the Generation of T Cell from Pluripotent Stem Cells"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Thomas Klein (Heinrich-Heine Universität Düsseldorf, Germany)
"Neuralized- and Mib1-Mediated Activation of Ser-Signalling"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Paul Langridge (Augusta University, United States)
"An in Vivo Screen to Identify Protein Domains that are Cleaved in Response to Force Provided by Epsin-Mediated Ligand Endocytosis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
David Perez (Moffitt Cancer Center, United States)
"Protein Design Approaches to Targeted Modulation of Notch Receptor Signaling"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Carmen Santa Cruz Mateos (University of Cambridge, United Kingdom)
"Notch Activity Coordinates Dynamic Mastermind “Hubs” to Instruct Transcription"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Yeqiao Zhou (University of Pennsylvania, United States)
"Optical Reconstruction of EBF1-Driven Enhancer-Promoter Hubs in Individual Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Fabio Turetti (Charles University, Czech Republic)
"Casein Kinase 1 Alpha (CK1a) Fine-Tunes Notch Intracellular Domain 1 (N1ICD) Stability and Function"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Notch and Cardiovascular Disorders
Discussion Leader: Joseph Arboleda-Velasquez (Schepens Eye Research Institute, Mass Eye and Ear / Harvard Medical School, United States)
9:00 am - 9:20 am
Luisa Iruela-Arispe (Northwestern University, United States)
"Notch Signaling in Vascular Cells, New Directions and More Surprises"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Joseph Arboleda-Velasquez (Schepens Eye Research Institute, Mass Eye and Ear / Harvard Medical School, United States)
"Role of Notch Signaling in Vascular Aging"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Samira Hosseini Alghaderi (University of Manchester, United Kingdom)
"Heterogeneous Outcomes of Different CADASIL Mutants on Endocytic NOTCH3 Activation Mechanisms"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Milagros Romay (Northwestern University, United States)
"Elucidating of the Molecular Progression of Hereditary Vascular Dementia in a Novel Mouse Model"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Rong Wang (University of California, San Francisco, United States)
"Notch Signaling in Arterial Venous Programming, Disease, and Regeneration"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jose Luis De La Pompa (Centro Nacional de Investigaciones Cardiovasculares , Spain)
"The Genetics of Cardiomyopathy and Bicuspid Aortic Valve Involves NOTCH Signaling Disruption"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Said Arevalo-Alquichire (Schepens Eye Research Institute of Mass Eye and Ear/ Harvard Medical School, United States)
"Inhibition of RUNX1 Curbs Vascular Pathology and Inflammation in CADASIL"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Jacob Neethling (University of Illinois at Chicago, United States)
"Notch Transcriptional Target Tmtc1 Maintains Vascular Homeostasis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tools to Study Notch Signaling in Tissue Development and Diseases
Discussion Leaders: Ishita Jain (Stanford University, United States) and Thilinie Bandara (University of Illinois at Chicago, College of Medicine, United States)
7:30 pm - 7:50 pm
Gregory Underhill (University of Illinois at Urbana-Champaign, United States)
"Tissue Microenvironment Engineering for the Study of Liver Differentiation and Notch Signaling"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Kostandin Pajcini (University of Illinois at Chicago, United States)
"Hematopoietic Notch Signaling in the Fetal and Adult Liver"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Lena Tveriakhina (Harvard Medical School, United States)
"Visualization of Notch Signaling Dynamics in Development and Tissue Homeostasis"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Pranav Saligrama Ramesh (University of Calgary, Canada)
"The Notch Ligand DLL1 Defines a Balance Between Trans-Activation and Cis-Inhibition to Regulate Human Somitogenesis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Jeffrey Savas (Northwestern University, Feinberg School of Medicine, United States)
"Notch Receptor-Ligand System Facilitates Extracellular Vesicle-Mediated Neuronal Communication"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Angelika Doetzlhofer (Johns Hopkins University, United States)
"The Dual Role of Notch Ligand Jagged1 in Cochlear Supporting Cell Plasticity and Hair Cell Regeneration"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Stem Cell and Niche Interactions
Discussion Leader: Irwin Bernstein (Fred Hutchinson Cancer Center, United States)
9:00 am - 9:20 am
Linda Samuelson (University of Michigan, United States)
"Notch, Niches and Regulation of Intestinal Stem Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Brandon Hadland (Fred Hutchinson Cancer Research Center, United States)
"Deconstructing Notch-Dependent Vascular Niche Signals to Engineer HSC Development ex vivo "
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Francesca Matteini (Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Spain)
"A Notch Trans-Activation to Cis-Inhibition Switch Underlies Hematopoietic Stem Cells Aging"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Kristen Johnson (Fred Hutchinson Cancer Center, United States)
"DLK1 Phase Separation Controls Multiple Signaling Pathways"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Silvia Fre (Institut Curie, France)
"Symmetry Breaking and Self-Organization of Bi-Layered Epithelia are Orchestrated by Conserved Signals During Development and Regeneration"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Susan Cole (The Ohio State University, United States)
"Coordinated Regulation of Notch Signaling by Glycosylation and Cis Inhibition"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Lan Zhou (Houston Methodist Hospital Research Institute, United States)
"Targeting Endothelial PERK-DLL4 Axis to Enhance Hematopoietic Stem Cell and Lymphoid Progenitor Regeneration"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Bolormaa Munkhbileg (University of Pennsylvania, Perelman School of Medicine, United States)
"Hyperactive Notch Signaling as a Potential Mechanism of PIGA– HSPC Clonal Expansion in Immune Bone Marrow Injury"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Transcription, Epigenetics, and Notch
Discussion Leader: Warren Pear (University of Pennsylvania, United States)
7:30 pm - 7:50 pm
Tilman Borggrefe (University of Giessen, Germany)
"Comprehensive Genomic Features Indicative for Notch Responsiveness"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Juan Carlos Zuniga-Pflucker (University of Toronto, Canada)
"T cells and Notch, a Lifelong Engagement"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Rajwinder Lehal (Cellestia Biotech AG, Switzerland)
"CSL as a Target for Inducing Immune Tolerance by Modulating Treg Cells and Application in Autoimmune Diseases"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Robert Faryabi (University of Pennsylvania, United States)
"Oncogenic Transcription Factors Instruct Promoter-Enhancer Hubs in Individual Triple Negative Breast Cancer Cells"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Jianning Tao (Sanford Research/USD, United States)
"Comprehensive Characterization of a Notch3-driven Preclinical Mouse Model of Lateral Meningocele Syndrome"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Rui Zhang (Maastricht University, The Netherlands)
"Divalent Metal Transporter 1(DMT1) Modulates Notch Signaling by Influencing Iron Storage and Lysosomal Stability"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure