SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Introductory Comments by GRC Site Staff / Welcome by Bill Nauseef (University of Iowa) |
7:40 pm - 9:30 pm | NOX FLAVOPROTEINS: BIOCHEMICAL INSIGHTS, BIOLOGICAL PRINCIPLES, & GAPS IN CURRENT UNDERSTANDING |
7:40 pm - 7:50 pm | Discussion Leader: Karl-Heinz Krause (Centre Medical Universitaire, Geneva, Switzerland) |
7:50 pm - 8:20 pm | Bettie Sue Masters (University of Texas Health Science Center at San Antonio)
"Roles of Heme- and Flavin-Requiring Proteins in Xeno/Endobiotic Metabolism and Cell Signaling" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Rikard Holmdahl (Lund University, Sweden)
"From disease to genes: revealing an oxidation path" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Miklós Geiszt (Semmelweis University, Budapest, Hungary)
"Nox/Duox family of NADPH oxidases: gaps in knowledge" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NOX2 IN PHAGOCYTES & THEIR RELATIVES |
9:00 am - 9:10 am | Discussion Leader: Françoise Morel (UJF-CHU, Grenoble, France) |
9:10 am - 9:30 am | Françoise Morel (UJF-CHU, Grenoble, France)
"Revisiting the phagocyte NADPH oxidase Nox2" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:00 am | Susan Smith (Emory University)
"(Homology) Models and (Evolutionary) Design: Project Nox" |
10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break / Group Photo |
10:30 am - 11:00 am | Edgar Pick (Tel Aviv University, Israel)
"Identification of the binding site(s) for p67phox on Nox2 - A methodological journey (Dr. Lambeth, I presume?)" |
11:00 am - 11:15 am | Discussion |
11:15 am - 11:45 am | Sebastian Amigorena (INSERM, Paris, France)
"Regulation of the phagosomal pH in dendritic cells" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Ellen Van Beek (Sanquin, Amsterdam, Netherlands)
"Negative regulation of the phagocyte NADPH oxidase by signal regulatory protein alpha" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Katharina Von Loehneysen (The Scripps Research Institute, USA)
"Mutagenesis of p22phox defines regions critical for Nox4 versus Nox2 function" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NOX REGULATION |
7:30 pm - 7:40 pm | Discussion Leader: Robert A. Clark (University of Texas Health Science Center at San Antonio) |
7:40 pm - 8:05 pm | Mark Quinn (Montana State University)
"Transcriptional Regulation of the Phagocyte NADPH Oxidase" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Becky Diebold (Emory University)
"14-3-3 Proteins Regulate Nox Activation" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Mary Dinauer (Indiana University)
"Regulation of the phagocyte NADPH oxidase" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | OXIDANT-MEDIATED SIGNALING & ITS CONSEQUENCES |
9:00 am - 9:10 am | Discussion Leader: Ulla G. Knaus (Scripps Research Institute, La Jolla) |
9:10 am - 9:35 am | Ben Boivin (Cold Spring Harbor)
"Redox regulation of protein tyrosine phosphatase function" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:00 am | Stanislas C. Morand (LHD, NIAID, NIH)
"Duox maturation factors are co-transported to the cell surface with Duox enzymes and affect the specifity of extracellular reactive oxygen generation" |
10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:30 am - 10:55 am | Philip Eaton (The Rayne Institute, London, UK)
"Thiol-based redox sensing and signaling in the cardiovascular system" |
10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Francis Miller (University of Iowa)
"Nox1 and the Signaling Endosome: Compartmentalization of ROS" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Karl-Heinz Krause (Centre Medical Universitaire, Geneva, Switzerland)
"NOX1, the mystery NOX: it's called the hidden paw" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NOX IN NON MAMMALS |
7:30 pm - 7:40 pm | Discussion Leader: Dave Lambeth (Emory University) |
7:40 pm - 8:05 pm | Chris Chang (University of California, Berkeley)
"Chemical Tools for Probing Hydrogen Peroxide in Living Systems" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Jesus Aguirre (Instituto de Fisiología Celular-UNAM, Mexico City)
"NADPH Oxidases Regulate Cell Differentiation and Growth in Fungi" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Harald Schmidt (Monash University, Clayton, Australia)
"Comparison of chemically distinct NADPH oxidase inhibitors and their applicability for pharmacological proof-of-principle studies" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Wine & Cheese Reception |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NOXES BEYOND PHAGOCYTES |
9:00 am - 9:10 am | Discussion Leader: Kathy Griendling (Emory University) |
9:10 am - 9:35 am | John Englehardt (University of Iowa)
"Endosomal Regulation of Nox2 in Health and Disease" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:00 am | Alicia N. Lyle (Emory University)
"NoxR1, a Novel Regulator of Nox4 Localization in Vascular Smooth Muscle Cells" |
10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:30 am - 10:55 am | Agnes Görlach (German Heart Center, Munich)
"NADPH oxidases in cellular stress signaling" |
10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Gregory E. Conner (University of Miami)
"Bacterial challenge and Duox2: regulation of epithelial host defense" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Botond Banfi (University of Iowa)
"Therapeutic potentials of altered NADPH oxidase activity" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session III |
6:00 pm | Dinner |
7:15 pm - 7:20 pm | Business Meeting (Part 1) |
| (Nominations for the next Vice Chair) |
7:20 pm - 9:30 pm | NOXES IN PHYSIOLOGY I |
7:20 pm - 7:30 pm | Discussion Leader: Ralf P. Brandes (J.W. Goethe-University, Frankfurt am Main, Germany) |
7:30 pm - 7:55 pm | Ajay Shah (King's College London, UK)
"Contrasting cardiovascular roles of Nox2 and Nox4 in gene-modified mice" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Masuko Ushio-Fukai (University of Illinois at Chicago)
"Role of NADPH oxidase in Neovascularization and Stem/Progenitor Cell Function" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Kathy Griendling (Emory University)
"Distinct roles of Nox1 and Nox4 in vascular biology" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Stephanie Carnesecchi Acker (Centre Medical Universitarie, Geneva, Switzerland)
"The NADPH oxidase NOX1 plays a crucial role in hyperoxia-induced lung injury" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting (Part 2) |
| (Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:00 am - 12:30 pm | NOXES IN PHYSIOLOGY II |
9:00 am - 9:10 am | Discussion Leader: Ajay Shah (King's College, London, UK) |
9:10 am - 9:35 am | Albert van der Vliet (University of Vermont)
"Dual oxidase in the airway epithelium: Not just for host defense" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:00 am | Xavier De Deken (Universite Libre de Bruxelles, Brussels, Belgium)
"Dual oxidase 1 activity is directly regulated via phosphorylations by the protein kinase A" |
10:00 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:30 am - 10:55 am | Victor Thannickal (University of Michigan)
"Nox Enzymes in Lung Injury, Repair, and Fibrosis" |
10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Patty Lee (Yale University)
"Toll-like Receptor 4 and Nox 3 in the Lung: An Untold Story" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Isabel Fabregat (Fundació Institut d'Investigació Biomèdica de Bellvitge, Barcelona, Spain)
"Role of Nox4 in the apoptosis induced by TGF in hepatocytes: implications in hepatocarcinogenesis" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session IV |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | DUOX & NOX5: ACTIVITY AND FUNCTION |
7:30 pm - 7:40 pm | Discussion Leaders: Miklós Geiszt (Semmelweis University, Budapest, Hungary) |
7:40 pm - 8:05 pm | François Miot (Université Libre de Bruxelles, Brussels, Belgium)
"How are Duox activities regulated?" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Tom Leto (National Institute of Allergy & Infectious Diseases, NIH)
"Function of Duox isozymes as extracellular reactive oxygen species generators" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Tsukasa Kawahara (Emory University)
"Evolutionary history of Nox/Duox: functional characterization of conserved regions" |
9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | Bill Nauseef (University of Iowa) & Miklós Geiszt (Semmelweis University, Budapest, Hungary)
"Closing Comments" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |