Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Thinking Outside of the BOX in NOX Signaling and
Homeostasis |
| Biochemistry of heme-mediated electron transfer systems in biology;
Understanding cellular redox events - targets and opportunities. |
| Discussion Leader: Robert Clark (University of Texas Health Science Center, USA) |
7:40 pm - 7:50 pm | Introduction by Discussion Leader |
7:50 pm - 8:25 pm | Michael Marletta (University of California, Berkeley, USA) "The Intersection of Heme Biochemistry, Nitric Oxide and Oxygen" |
8:25 pm - 8:40 pm | Discussion |
8:40 pm - 9:15 pm | Ursula Jakob (University of Michigan, USA) "Understanding Cellular Redox Events - Targets and Opportunities" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NOX Activation: From Protein Structure to Subunit Assembly |
| Ferredoxin
NADP+ reductase as a model system for flavoprotein-mediated electron transfer; Insights
into assembly of the NADPH oxidase complex;
NOX2 modulation of MHC-II antigen processing. |
| Discussion Leader: Edgar Pick (Sackler School of Medicine, Tel Aviv University, Israel) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:35 am | P. Andrew Karplus (Oregon State University, USA) "Ferredoxin NADP+ Reductase as a Model System for Flavoprotein-Mediated Electron Transfer" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Laura Baciou (CNRS / University of Paris-Sud, France) "Insights into Assembly of the NADPH Oxidase Complex" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Group Photo / Coffee Break |
10:50 am - 11:15 am | Nicolas Demaurex (University of Geneva, Switzerland) "Mechanisms and Impact of Nox Activation in Intracellular Compartments of Immune Cells" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:50 am | Anny Slama-Schwok (Institut National de la Recherche Agronomique (INRA) / INSERM, France) "Targeting the NADPH Site of NOX and NOS with Photoactive NADPH Derivatives: Structural Insights and Functional Implications" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Franck Fieschi (Université Grenoble Alpes, France) "Characterization of the Molecular Basis of Selectivity of NOXs Towards NADPH: NADPH Binding Mode in the NOX2 Active Site" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Sharon O'Neill (University College Dublin, Ireland) "Monitoring Conformational Dynamics of NADPH Oxidase Dimerization as a Novel Tool for Architecture-Based Screening" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NOXes and Microbial Sensing |
| NOX1-dependent epithelial microbial defenses and adaptation in the intestine;
Microbial sensing, NETosis, and NOX in phagocytes. |
| Discussion Leader: Albert Van Der Vliet (University of Vermont, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:05 pm | Andrew Neish (Emory University School of Medicine, USA) "Nox1-Dependent Epithelial Microbial Defenses and Adaptation in the Intestine" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Stavros Selemidis (Monash University, Australia) "Regulation of Virus Pathogenicity by Nox2 Oxidase" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Gabriella Aviello (National Children's Research Centre, Ireland) "Redox Regulation of Enteric Infection and Inflammation" |
9:15 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Metabolic and Inflammatory Mechanisms in NOX-Related
Pathophysiology |
| NOXes as novel metabolic regulators;
Mechanisms of NOX2-related inflammation in the central nervous system;
Mechanisms and impact of NOX activation in intracellular compartments of immune cells. |
| Discussion Leader: Ulla Knaus (Conway Institute, University College Dublin, Ireland) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:35 am | Anna Zoccarato (King's College London, United Kingdom) "Noxes as Novel Metabolic Regulators" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Menachem Rubinstein (Weizmann Institute of Science, Israel) "How Does Endoplasmic Reticulum Stress Trigger Oxidative Stress and DNA Damage?" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Simone Di Giovanni (Imperial College London, United Kingdom) "Nox-Dependent Regulation of Nerve Regeneration" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:50 am | Jaehyung (Gus) Cho (University of Illinois at Chicago, USA) "Nox2 in Platelet-Neutrophil Interaction During Thromboinflammatory Disease" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Daniel Suter (Purdue University, USA) "NOX2/CYBB Is Required for Retinotectal Development in Zebrafish" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Mary Dinauer (Washington University in St. Louis School of Medicine, USA) "A Role for NCF2 in the Genetic Predisposition to SLE: Studies in Lupus-Prone NZM.2329 Mice" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NOXes Under Pressure: Responses to Mechanobiological Stimuli and Cell Stress |
| NOX physiology and epigenetics in endothelial shear stress response and atherosclerosis;
Reactive oxygen species-dependent mechanisms in flow-mediated vascular remodeling. |
| Discussion Leader: Kathy Griendling (Emory University, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:05 pm | Hanjoong Jo (Emory University, USA) "Role of Noxes in Flow-Dependent Regulation of Endothelial Inflammation and Atherosclerosis" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Roberto Sitia (Vita-Salute San Raffaele University, Italy) "Stress Modulates NOX-Dependent H2O2 Signaling by Gating Aquaporin-8" |
8:40 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Corinne Dupuy (Institut Gustave Roussy / CNRS, France) "Role of NADPH Oxidase Duox1 in Thyroid Radiocarcinogenesis" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Novel Modes of NOX Regulation |
| NRROS:
A novel NOX2 regulator – role in host defense and autoimmunity;
HACE-1 ubiquitin ligase and kinase-mediated Rac1 regulation in CNS pathophysiology;
Redox regulation of RhoGTPases and implications
in NOX-mediated signaling. |
| Discussion Leader: Miklos Geiszt (Semmelweis University, Hungary) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:35 am | Wenjun Ouyang (Amgen Inc., USA) "NRROS Regulates ROS Production and Plays an
Essential Role in Neurological Homeostasis" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Bo Rafn (BC Cancer Research Centre, Canada) "HACE-1 Ubiquitin Ligase and Kinase-Mediated Rac1 Regulation in CNS Pathophysiology" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Ramnik Xavier (Massachusetts General Hospital, USA) "Functional Genomics Discloses Novel Regulatory Nodes Controlling Nox2" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:50 am | Sharon Campbell (University of North Carolina, USA) "Redox Regulation of RhoGTPases and Implications in Nox-Mediated Signaling" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Chet Holterman (Kidney Research Centre, Ottawa Hospital Research Institute, Canada) "Toll-Like Receptors and NADPH Oxidase 5 Activity: Oxidative Stress Takes a Toll on Renal Function" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Moo-Yeol Lee (Dongguk University, South Korea) "Interplay Between Calcium and Reactive Oxygen Species in Vascular Smooth Muscle Angiotensin II Signaling" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | NOX Genetics and Epigenetics |
| Epigenetic regulation of NOXes;
NOXes and cardiovascular phenotype of Williams
Syndrome. |
| Discussion Leader: Mary Dinauer (Washington University in St. Louis School of Medicine, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:05 pm | Victor Thannickal (University of Alabama at Birmingham, USA) "Epigenetic Regulation of Noxes" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Beth Kozel (National Heart, Lung, and Blood Institute, NIH, USA) "Nox as a Modifier of Elastin-Mediated Vascular Disease" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Francis Miller (Duke University, USA) "Integrated Micro-RNA Regulation of Nox4" |
9:15 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NOXes in the Pathogenesis and Progression of
Cancer |
| Mechanisms of NOX 4-mediated protection against liver cancer;
NOX-derived hydrogen peroxide and cancer pathophysiology; Interplay between NOXes and p53 in inflammation
and cancer. |
| Discussion Leader: Corinne Dupuy (Institut Gustave Roussy / CNRS, France) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:35 am | Isabel Fabregat (Bellvitge Biomedical Research Institute (IDIBELL), Spain) "A Mechanistic Approach to Nox4-Mediated Protection Against Liver Cancer" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Katrin Schroder (Goethe-Universität Frankfurt am Main, Germany) "Nox-Derived Hydrogen Peroxide and Cancer Pathophysiology" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:15 am | Thomas Leto (National Institute of Allergy and Infectious Diseases, NIH, USA) "Interplay Between Nox4 and p53 in Tumor
Progression and Cancer Cell Migration" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Rabii Ameziane El Hassani (Unité de Biologie et de Recherche Médicale, CNESTEN, Morocco) "NADPH Oxidase NOX4 Is a Critical Mediator of BRAFV600E-Induced Down Regulation of the Sodium Iodide Symporter in Papillary Thyroid Carcinomas" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Karamatullah Danyal (University of Vermont, USA) "Role of Dual Oxidase1 in Regulation of Mitochondrial ROS Production for Wound Repair in Lung Epithelium" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Alejandra Valdivia (Emory University, USA) "NOX1 Regulates Polarity During Cell Migration" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Julie Brault (Universite Grenoble Alpes, France) "Protein-Based Therapies for the Treatment of Chronic Granulomatous Disease: Proof-of-Concept on iPSC-Derived X0- and AR470-CGD Macrophages" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | NOX Inhibitors: Perspectives and Critical Analysis |
| High-throughput screening of a library of FDA-approved bioactive compounds as inhibitors of
NADPH oxidase and pancreatic cancer;
NOX inhibitors: first clinical studies and new developments. |
| Discussion Leader: David Lambeth (Emory University, USA) |
5:30 pm - 5:40 pm | Introduction by Discussion Leader |
5:40 pm - 6:05 pm | Jacek Zielonka (Medical College of Wisconsin, USA) "High-Throughput Screening of a Library of FDA-Approved Bioactive Compounds as Inhibitors of NADPH Oxidase and Pancreatic Cancer" |
6:05 pm - 6:15 pm | Discussion |
6:15 pm - 6:30 pm | Philippe Wiesel (Genkyotex SA, Switzerland) "Nox Inhibitors: First Clinical Studies and New Developments" |
6:30 pm - 6:40 pm | Discussion |
6:40 pm - 6:55 pm | Per Wikstrom (Glucox Biotech AB, Sweden) "NOX Inhibitors in Development: Things to Consider" |
6:55 pm - 7:05 pm | Discussion |
7:05 pm - 7:20 pm | Patrick Pagano (University of Pittsburgh, USA) "Novel Nox Inhibitors: Challenges and Perspectives" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |