NOX Enzymes from Host Defense to Cell Signaling and Metabolic Disease

NADPH oxidase (NOX) enzymes are distributed widely in nature and have emerged as primary sources of regulated production of reactive oxygen-derived species (ROS). Although initially primarily known for their role(s) in host defense against pathogens, NOX enzymes are now recognized to play highly diverse roles in biological systems by redox-based regulation of various cell signaling pathways, a concept that has diverged substantially from the more traditional viewpoint of ROS as damaging and stress-inducing agents. Functional roles of NOX enzymes in various aspects of biology are being discovered at a rapid pace, and dysregulated NOX function due to e.g. genetic NOX variants or inappropriate activation is increasingly implicated in disease pathology, and continues to fuel the search for NOX-selective inhibitors for potential clinical translation.

The NOX GRC brings together scientists from highly diverse disciplines at this premier forum to discuss state-of-the-art research in this field in a collegial, collaborative and informal atmosphere. The 2022 NOX GRC focuses on innovative and paradigm-challenging topics, presented by internationally recognized experts and will allow ample time for discussions coordinated by expert discussion leaders. Topics covered at the 2022 NOX GRC include: new developments with respect to host defense properties, structure/functional aspects of NOX enzymes, novel modes of NOX regulation and NOX-dependent signaling, and newly emerging interactions of NOX with mitochondrial biology and implications for cell metabolism. The meeting will also address ongoing translational studies addressing the involvement of NOX in chronic inflammatory diseases and cancer, and progress with development of new NOX inhibitors, some of which are in clinical development.

The NOX GRC is organized to reflect gender and geographic diversity of the field, and will allow for inclusion of late-breaking science and short talks selected from trainee abstracts. The meeting also includes stimulating poster sessions, preceded by elevator pitch-style preview presentations, which will allow for more extensive discussion and facilitate career development opportunities for early-career investigators in this field. Please do not miss out on this exciting meeting!