| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Basics of Nox Family Biology:
Structural Insights and Regulatory Mechanisms/Advances in NADPH Oxidase-Associated Proteins |
| Discussion Leaders: Hitesh Peshavariya (University of Melbourne, Australia) and William Nauseef (University of Iowa, USA) |
| 3:45 pm - 3:50 pm | Introduction by Discussion Leader |
| 3:50 pm - 4:05 pm | David Heppner (University of Vermont, USA)
"Concerted Roles of DUOX1 and NOX2 in Redox Regulation of Epidermal Growth Factor Receptor Signaling" |
| 4:05 pm - 4:10 pm | Discussion |
| 4:10 pm - 4:25 pm | Arturo Simoni (Universidad Autónoma Metropolitana, Mexico)
"Hepatocyte Growth Factor Regulates p22 Phox Through Transcriptional and Post-Translational Mechanisms" |
| 4:25 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Functional Roles of Nox:
From the Single Cell to the Complex Organism |
| Discussion Leaders: Siobhan Craige (University of Massachusetts Medical School, USA) and Ulla Knaus (Conway Institute, University College Dublin, Ireland) |
| 7:30 pm - 7:35 pm | Introduction by Discussion Leader |
| 7:35 pm - 7:55 pm | Jacek Zielonka (Medical College of Wisconsin, USA)
"Superoxide and Hydrogen Peroxide Detection in Biological Systems: From Theory to Practice" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:05 pm | Introduction by Discussion Leader |
| 8:05 pm - 8:20 pm | Ana Caroline Gandara (Instituto de Bioquímica Médica Leopoldo de Meis, Brazil)
"NOXm Is Not Restricted to Hematophagous Diptera: A Thorough Characterization of NOXm in Arthropods" |
| 8:20 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:40 pm | Tiphany De Bessa (Heart Institute of the University of São Paulo, Brazil)
"Ras Overactivation as a Potential Mechanism for Disrupted Protein Disulfide Isomerase/NADPH Oxidases Interaction" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:00 pm | Naomi Boisvert (University of Ottawa, Canada)
"TRPC5 Is Required for NADPH Oxidase 5 Activity in Podocytes" |
| 9:00 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:20 pm | Aslihan Terzi (Purdue University, USA)
"Generation of Zebrafish Lines with Mutations in Individual NADPH Oxidase Isoforms Using CRISPR/Cas9 Genome Editing" |
| 9:20 pm - 9:25 pm | Discussion |
| 9:25 pm - 9:30 pm | General Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Exploiting Nox Effects: Signalling Pathways, Inhibition, and Therapeutic Applications |
| Discussion Leaders: Leonardo Tanaka (Heart Institute of the University of São Paulo, Brazil) and Rhian Touyz (University of Glasgow, United Kingdom) |
| 9:00 am - 9:05 am | Introduction by Discussion Leader |
| 9:05 am - 9:25 am | Matteo Beretta (King's College Hospital, United Kingdom)
"HyPer Probes: A Powerful Tool for Specific Localization of H2O2 in Living Cells" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:35 am | Introduction by Discussion Leader |
| 9:35 am - 9:50 am | Karamatullah Danyal (University of Vermont, USA)
"Role of Dual Oxidase1 in Regulation of Mitochondrial ROS Production for Wound Repair in Lung Epithelium" |
| 9:50 am - 9:55 am | Discussion |
| 9:55 am - 10:10 am | Sharon O'Neill (University College Dublin, Ireland)
"Monitoring Conformational Dynamics of NADPH Oxidase Dimerization as a Novel Tool for Architecture-Based Screening" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am - 10:30 am | Carmen Veith (Maastricht University, The Netherlands)
"NADPH Oxidases Induce Oxidative Damage in an In Vitro Model of Pulmonary Fibrosis" |
| 10:30 am - 10:35 am | Discussion |
| 10:35 am - 10:50 am | Moritz Schnelle (King's College London, United Kingdom)
"NADPH Oxidase-4 Mediates Cardiac Adaptation to Volume Overload" |
| 10:50 am - 10:55 am | Discussion |
| 10:55 am - 11:00 am | General Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Panel and Workshop Discussions |
| Discussion Leaders: Hitesh Peshavariya (University of Melbourne, Australia) and Siobhan Craige (University of Massachusetts Medical School, USA) |
| 1:30 pm - 2:30 pm | Panel Discussion |
| "NOX-ROS Where, When and How; Targeting NOX Going from Inhibitors to Therapies; A Career in the NOX Field" |
|
- Ulla Knaus (Conway Institute, University College Dublin, Ireland)
- Francisco Laurindo (Heart Institute of the University of São Paulo, Brazil)
- William Nauseef (University of Iowa, USA)
- Rhian Touyz (University of Glasgow, United Kingdom)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
