Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Structure and Regulation of NADPH Oxidase Enzymes
3:15 pm - 3:20 pm
Introduction by Discussion Leader
3:20 pm - 3:35 pm
"New Approaches for the Biochemical and Structural Characterization of NOX5"
3:35 pm - 3:40 pm
Discussion
3:40 pm - 3:55 pm
"A Novel Combinatorial Technique to Detect Superoxide Anions Elucidates NADPH Oxidase-Dependent Regulation of Human Platelets"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Biological Roles of NADPH Oxidases and Redox Signaling: From the Single Cell to the Complex Organism
5:30 pm - 5:35 pm
Introduction by Discussion Leader
5:35 pm - 5:55 pm
"Poldip2 Effect on Nox2 and Nox4 Activity"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
"Protein Disulfide Isomerase-A1 Coordinates NADPH Oxidase Subtype-Dependent Mechanisms Promoting Vascular Smooth Muscle Phenotypic Switches"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"NOX5 Regulation of Vascular Contraction Involves Oxidation of ER Calcium Channels and Calreticulin"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:10 pm
"Profibrotic Signaling by TGF-β1 Involves NADPH Oxidase 4-Dependent Activation of the Tyrosine Kinase Fyn"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
NADPH Oxidases in Health and Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"New Insights into the Molecular Mechanisms Regulated by the NADPH Oxidase NOX4 in Hepatocellular Carcinoma"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"NOX1 Dependent Redox Signaling Mediates Colonic Stem Cell Proliferation via EGFR Potentiated by Microbial Components"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Interplay Between Nox-Regulated Oxidative Stress and ER Stress Response in Experimental Hypertension"
10:15 am - 10:20 am
Discussion
10:20 am - 10:40 am
"NOX2-Selective Small Molecule Inhibitors Ameliorate TNFa-Stimulated Endothelial Cell Activation and Dysfunction"
10:40 am - 10:45 am
Discussion
10:45 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Your Scientific Career Path
1:30 pm - 2:30 pm
Panel Discussion
Navigating Your Scientific Career Path
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes