Session I. Spectroscopic applications and physical methods
Sunday, July 4 (evening) |
| Chair: Paul Hagerman |
| 7:30 PM |
Paul Hagerman (U. Colo. School Med.):
"Global conformations of nucleic acids in solution using TEB" |
| 8:00 PM |
Tom Kerppola (U. Michigan):
"Transcription factor flip-flop: The orientation of Fos-Jun heterodimer binding" |
| 8:30 PM |
David Millar (Scripps):
"Nucleic acid structure from time-resolved FRET" |
| 9:00 PM |
COFFEE BREAK |
| 9:30 PM |
Michael Brenowitz (Albert Einstein):
"Using time-resolved synchrotron x-ray footprinting to study macromolecular dynamics" |
| 10:00 PM |
Peter Kollman (UCSF):
"Molecular dynamics simulations on nucleic acid systems" |
Session II. DNA and RNA as disease-related targets
Monday, July 5 (morning) |
| Chair: Joel Gottesfeld |
| 9:00 AM |
Joel Gottesfeld (Scripps):
Regulation of Gene Expression by Synthetic DNA Binding Ligands" |
| 9:30 AM |
Carl Pabo (MIT):
"Zn-Finger Transcription Antagonists" |
| 10:00 AM |
Greg Verdine (Harvard):
"Design of Nonnatural Transcription Activators" |
| 10:30 AM |
COFFEE BREAK |
| 11:00 AM |
Eric Wickstrom (Thomas Jefferson University):
"Transposon Tn7 Gene Insertion into an Evolutionarily Conserved Human Homolog of Escherichia coli attTn7" |
| 11:30 AM |
Bernard Cuenoud (Novartis Pharma AG):
"Dual Recognition of DNA" |
Session III. DNA synthesis and repair
Monday, July 5 (evening) |
| Chair: Larry Loeb |
| 7:30 PM |
Larry Loeb (U. Washington)
"Creation of Mutant DNA Polymerases" |
| 8:00 PM |
Tom Kunkel (NIEHS - Research Triangle Park)
"Structure and Function Studies on the Fidelity of DNA Replication" |
| 8:30 PM |
Eric Kool (Rochester):
"The Importance of Shape Matching in Replication and Repair." |
| 9:00 PM |
COFFEE BREAK |
| 9:30 PM |
John Essigmann (MIT):
"Design of Agents that Block DNA Repair" |
| 10:00 PM |
Michael Fry (Israel Institute of Technology)
"Unwinding of Tetrahelical DNA by DNA Helicases and DNA Binding Proteins." |
Session IV. Diversity and combinatorial approaches
Tuesday, July 6 (morning) |
| Chair: David Bartel |
| 9:00 AM |
David Bartel (MIT):
"Creation and Evolution of New Ribozymes" |
| 9:30 AM |
Ronald Breaker (Yale University)
"Catalytic DNA and Allosteric Ribozymes" |
| 10:00 AM |
Alan Frankel (UCSF)
"Design and Evolution of RNA-Protein Interactions" |
| 10:30 AM |
COFFEE BREAK |
| 11:00 AM |
Rich Roberts (Caltech)
"In Vitro protein selection using RNA-protein fusions" |
| 11:30 AM |
Phillip Patten (Maxygen, Inc.)
"Rapid evolution of genes, plasmids and viruses using DNA shuffling" |
Session V. Transcription
Tuesday, July 6 (evening) |
| Chair: Michael R. Green |
| 7:30 PM |
Michael R. Green (UMass Medical Center):
"Functional Analysis of TFIID Components In Vivo" |
| 8:00 PM |
Michael Carey (UCLAr):
"Enhanceosome assembly and function in pol II transcription" |
| 8:30 PM |
Winship Herr (Cold Spring Harbor Laboratory):
"Transcriptonal Regulatory Mechanisms: Putting the Pieces Together" |
| 9:00 PM |
COFFEE BREAK |
| 9:30 PM |
Alanna Schepartz (Yale University):
"A Closer Look at Hepatitis B Virus pX" |
| 10:00 PM |
Rick Wobbe (Scriptgen):
"Gene Transcription as a Tool and a Target for Drug Discovery" |
Session VI. RNA and processing
Wednesday, July 7 (morning) |
| Chair: Tom Cech |
| 9:00 AM |
Scott Strobel (Yale)
"Defining the chemical basis of group I intron function" |
| 9:30 AM |
Tom Cech (Colorado)
"RNA Structure by X-ray crystallography" |
| 10:00 AM |
Art Pardi (Colorado)
"New NMR techniques for probing solution structure and dynamics in RNA" |
| 10:30 AM |
COFFEE BREAK |
| 11:00 AM |
Joan Steitz (Yale)
"The RNA machinery of the nucleolus" |
| 11:30 AM |
Wes Sundquist (Utah)
"Structural Studies of the HIV-1 Core Particle" |
Session VII. RNA transport
Wednesday, July 7 (evening) |
| Chair: James Dahlberg |
| 7:30 PM |
Karsten Weis (UC - Berkeley):
"RNA export in S. cerevisiae" |
| 8:00 PM |
Sara Nakielny (U Penn)
"Factors promoting nuclear RNA export" |
| 8:30 PM |
Mutsuhito Ohno (EMBL)
"Export of U snRNAs from the nucleus" |
| 9:00 PM |
COFFEE BREAK |
| 9:30 PM |
James Dahlberg (Wisconsin):
"Proofreading of RNAs during Nuclear Export" |
| 10:00 PM |
Kimberly Mowry (Brown):
"Cytoplasmic RNA Transport in Xenopus Oocytes" |
Session VIII. The Ribosome and translation
Thursday, July 8 (morning) |
| Chair: Harry Noller |
| 9:00 AM |
Roy Parker (Arizona)
"Mechanisms and Control of mRNA Turnover in Eukaryotes" |
| 9:30 AM |
Betsy Goodwin (Northwestern)
"Post-transcriptional control of sex determination in C. elegans" |
| 10:00 AM |
COFFEE BREAK (Election of co-chairs for 2001) |
| 10:30 AM |
Brian Wimberly (Utah):
"A detailed view of a ribosomal active site: structure of the GTPase center" |
| 11:00 AM |
Tom Steitz (Yale)
"The structure of the large ribosomal subunit" |
| 11:30 AM |
Harry Noller (UC Santa Cruz)
"Functional Ribosomal Complexes" |
Session IX. Late-Breaking Developments
Thursday, July 8 (evening) |
| Co-chairs: Jim Maher and Jamie Williamson |
| 7:30 PM |
Nancy Craig (Johns Hopkins):
"Transposon Tn7 can Selectively Insert at Triplex DNA" |
| 8:00 PM |
David Lockhart (Affymetrix/Novartis Genomics Institute):
"Genes, Genomics, and DNA chips" |
| 8:30 PM |
Alan Herbert (MIT):
"Structure/function studies on the Z-DNA binding domain of the mammalian RNA editing enzyme ADAR1" |
| 8:50 PM |
Steve Scaringe (Dharmacon):
"Advances and Advantages in 5'-Silyl-2'-Orthoester RNA Synthesis" |
| 9:10 PM |
COFFEE BREAK (20 minutes) |
| 9:30 PM |
Liz Gavis (Princeton):
"Developmental regulation of Drosophila nanos RNA by 3'UTR sequences" |
| 9:50 PM |
Marv Wickens (Wisconsin):
"3'UTR and poly(A) mediated controls" |
| 10:20 PM |
Joe Piccirilli (U. Chicago):
"Mechanism of RNA-Catalyzed Phosphoryl Transfer Revealed by Modified Nucleic Acids" |
