From Organization and Regulation to Structure and Mechanisms of Nucleic Acid Biology

June 1 - 2, 2019

Chairs

and

Grand Summit Hotel at Sunday River

97 Summit Road

Newry, Maine, United States

Venue and Travel Information

Conference Description

The Gordon Research Seminar on Nucleic Acids is a unique forum for graduate students, post-docs, and other early career scientists with comparable levels of experience and education to present and exchange new data and cutting-edge ideas regarding all aspects of the biology and chemistry of Nucleic Acid.

This seminar provides an exceptional opportunity to build scientific insight and peer networks in a supportive environment before attending the larger GRC meeting. Attendees will have access to mentorship and career advice from experts in academia and industry. The format of the GRS allows ample time to not only highlight recent advances in nucleic acid biology and chemistry, but also an atmosphere for fruitful scientific discussion, interactions and the exchange of new ideas.

Topics of the 2019 Nucleic Acids GRS will include organization, regulation, structural insights, and mechanistic details across a wide range of nucleic acid biology, in addition to recent advances in RNA and DNA applications and technologies. The program will include three platform sessions with a total of 10-15 talks selected from abstracts, and two poster sessions. Sessions will be chaired by selected students/postdocs.

Related Meeting

This GRS will be held in conjunction with the "Nucleic Acids" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
2:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm	Nucleic Acid Technologies Discussion Leader:
3:45 pm - 3:55 pm	"Targeting Nucleic Acid Structures with Supramolecular Cylinders"
3:55 pm - 4:00 pm	Discussion
4:00 pm - 4:10 pm	"Designed RNA Enzyme as a Potential Antibacterial"
4:10 pm - 4:15 pm	Discussion
4:15 pm - 4:25 pm	"Chemical and Structural Studies Provide a Mechanistic Basis for Selective Recognition of the MYC G-Quadruplex"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Organization and Regulation of DNA and RNA Biology Discussion Leader:
7:30 pm - 7:40 pm	"CtIP DNA Binding Deficiencies Contribute to the Molecular Basis of Seckel 2 and Jawad Syndromes"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Conflicts Between a DNA End-Binding Protein and Transcription at Double-Strand Breaks"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Role of Alu Duplex RNAs in MDA5-Mediated Interferonopathies"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Translesion DNA Polymerase Zeta Suppresses an Innate Immune Response"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"An Orphan 3'-5' Polymerase Implicated in Noncoding RNA Processing"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Similarities and Differences in tRNA Quality Control Decay Pathways in Evolutionarily Distant Yeast Species"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Regulation of the Essential Human Ribosomal RNA Processing Machinery, Las1L-Nol9"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Structures and Mechanisms of Nucleic Acid Biology Discussion Leader:
9:00 am - 9:10 am	"The Complete Structure of the Human TFIIH Core Complex"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	"A Mechanism for Ligand Gated Strand Displacement in ZTP Riboswitch Transcription Regulation"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"The Role of Phosphorylation in DNA Damage Response in Mycobacterium"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Diversity, Molecular Mechanisms and Origins of RNAs Replicated by a Transcription Polymerase"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Mechanistic Insights into Eukaryotic mRNA 3' End Processing"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Active Site Coordination Within a Multienzyme Pre-rRNA Processing Complex"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"A Fragile Folding Interaction Controls Catalysis in the GlmS Ribozyme Riboswitch"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Regulation of Cyclic Oligoadenylate Synthesis by the S. epidermidis Cas10-Csm Complex"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Education, Career Development and Mentorship The mentorship session will include a keynote talk on careers in biology and an NIH/NSF career panel. Discussion Leader:
1:30 pm - 1:50 pm	"Careers in Biology"
1:50 pm - 2:00 pm	Discussion
2:00 pm - 2:30 pm	Panel Discussion NIH/NSF Careers
2:30 pm - 3:00 pm	Evaluation Period Fill in GRS Evaluation Forms
3:00 pm	Seminar Concludes

Contributors

Conference Links

Conference History Nucleic Acids

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